2005
The B1-subunit of the H+ ATPase is required for maximal urinary acidification
Finberg KE, Wagner CA, Bailey MA, Păunescu T, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP. The B1-subunit of the H+ ATPase is required for maximal urinary acidification. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 13616-13621. PMID: 16174750, PMCID: PMC1224669, DOI: 10.1073/pnas.0506769102.Peer-Reviewed Original ResearchConceptsMaximal urinary acidificationNormal urinary acidificationMetabolic acidosisUrinary acidificationDistal renal tubular acidosisAcid challengeRenal tubular acidosisAcute intracellular acidificationB1 subunitLumen-negative potentialFurosemide infusionTubular acidosisAlkaline urineDistal nephronGreater severityAcidosisMiceLoss of B1Intracellular acidificationApical expressionUrineDuctFurther decreaseIsoformsPlasma membrane
2002
Acid-base transport in the collecting duct.
Wagner CA, Geibel JP. Acid-base transport in the collecting duct. Journal Of Nephrology 2002, 15 Suppl 5: s112-27. PMID: 12027210.Peer-Reviewed Original ResearchConceptsDistal renal tubular acidosisRisk of nephrocalcinosisAcid-base transportRenal tubular acidosisAngiotensin IIMetabolic acidosisTubular acidosisBicarbonate handlingElectrolyte statusRenal electrolyteMetabolic statusAcidosisFinal secretionDuctTranscellular movementProtein mutationsGenetic diseasesStatusBicarbonateAldosteroneCellsNephrocalcinosisEndothelinLithiasisSyndrome