2018
Sa1180 - Activation of the Calcium Sensing Receptor (Casr) Leads to Enhanced Fluid and Electrolyte Absorption in the Rat Small Intestine
Lysyy T, Caturegli G, Finotti M, Maina R, Barahona M, D'Amico F, Mulligan D, Geibel J. Sa1180 - Activation of the Calcium Sensing Receptor (Casr) Leads to Enhanced Fluid and Electrolyte Absorption in the Rat Small Intestine. Gastroenterology 2018, 154: s-269-s-270. DOI: 10.1016/s0016-5085(18)31261-7.Peer-Reviewed Original ResearchModulations in extracellular calcium lead to H+-ATPase-dependent acid secretion: a clarification of PPI failure
Kitay AM, Schneebacher MT, Schmitt A, Heschl K, Kopic S, Alfadda T, Alsaihati A, Link A, Geibel J. Modulations in extracellular calcium lead to H+-ATPase-dependent acid secretion: a clarification of PPI failure. AJP Gastrointestinal And Liver Physiology 2018, 315: g36-g42. PMID: 29517927, DOI: 10.1152/ajpgi.00132.2017.Peer-Reviewed Original ResearchConceptsAcid secretionParietal cellsExtracellular calciumGastric parietal cellsProton pump inhibitor exposureExtracellular CaPotassium-free conditionsRecurrent reflux symptomsCalcium sensing receptorGastric acid secretionPPI failurePPI therapyReflux symptomsIsolated gastric glandsInhibitor exposureCalcimimetic R568Pharmacological targetsSensing receptorAbsence of sodiumCalcium concentrationCaSRGastric glandsSecretionATPase activityExcretion pathway
2013
The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule
Capasso G, Geibel PJ, Damiano S, Jaeger P, Richards WG, Geibel JP. The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule. Kidney International 2013, 84: 277-284. PMID: 23615500, DOI: 10.1038/ki.2013.137.Peer-Reviewed Original ResearchMeSH KeywordsAcid-Base EquilibriumAnimalsCalcimimetic AgentsCalciumHydrogen-Ion ConcentrationIn Vitro TechniquesKidney Tubules, ProximalMaleMiceMice, KnockoutNuclear ProteinsPerfusionPuncturesRatsRats, Sprague-DawleyReceptors, Calcium-SensingReceptors, G-Protein-CoupledSodium-Hydrogen ExchangersTranscription FactorsConceptsProximal tubulesLuminal calcium concentrationFluid reabsorptionAcid secretionKnockout miceCalcium ion concentrationCalcium concentrationRole of CaSRActivation of CaSRCalcium sensing receptorCalcium-sensing receptorMouse proximal tubulesProton secretionSodium-hydrogen exchangerCalcimimetic agentBicarbonate absorptionSensing receptorCaSRFluid absorptionSecretionReabsorptionMiceCalcimimeticsTubulesLuminal membrane
2009
S2062 Reversal of Osmotic Diarrhea Through Activation of the Rat Ileal Calcium Sensing Receptor (CaSR)
Ballwieser D, Joseph R, Sauter M, Geibel J. S2062 Reversal of Osmotic Diarrhea Through Activation of the Rat Ileal Calcium Sensing Receptor (CaSR). Gastroenterology 2009, 136: a-322-a-323. DOI: 10.1016/s0016-5085(09)61477-3.Peer-Reviewed Original Research