2006
Hypertonic Saline Attenuates Colonic Tumor Cell Metastatic Potential by Activating Transmembrane Sodium Conductance
Shields CJ, Winter DC, Geibel JP, O’Sullivan G, Wang JH, Redmond HP. Hypertonic Saline Attenuates Colonic Tumor Cell Metastatic Potential by Activating Transmembrane Sodium Conductance. The Journal Of Membrane Biology 2006, 211: 35-42. PMID: 16988862, DOI: 10.1007/s00232-006-0011-8.Peer-Reviewed Original ResearchConceptsHypertonic salineSodium-hydrogen exchangeIntegrin expressionIntracellular sodiumMetastatic potentialHuman colonic tumor cellsAdhesion molecule expressionSodium concentrationColonic tumor cellsTumor cell metastatic potentialIntracellular pHCell metastatic potentialCytosolic sodium concentrationMolecule expressionΒ1 integrin expressionHyperosmolar solutionsConfocal laser microscopic imagingEffect of hypertonicityTumor cellsInhibitory effectSodium responseHypertonic exposureCellular alkalinizationTumor cell-endothelial interactionsSodium conductance
1999
Rapid Effects of Aldosterone on Sodium-Hydrogen Exchange in Isolated Colonic Crypts
Winter D, Schneider M, O'Sullivan G, Harvey B, Geibel J. Rapid Effects of Aldosterone on Sodium-Hydrogen Exchange in Isolated Colonic Crypts. The Journal Of Membrane Biology 1999, 170: 17-26. PMID: 10398757, DOI: 10.1007/s002329900534.Peer-Reviewed Original ResearchMeSH KeywordsAldosteroneAmilorideAnimalsArachidonic AcidBicarbonatesColonDiureticsExtracellular SpaceFluoresceinsFluorescent DyesHydrogen-Ion ConcentrationIon ExchangeIon TransportLeukotriene AntagonistsMaleMineralocorticoid Receptor AntagonistsPhospholipasesProstaglandin AntagonistsProtein BiosynthesisProtein Kinase InhibitorsProtein KinasesProtein Synthesis InhibitorsRatsRats, Sprague-DawleySodiumSodium-Hydrogen ExchangersSpironolactoneTranscription, GeneticConceptsProtein synthesisRapid cellular responsesSignal transduction pathwaysProtein kinase CSodium-hydrogen exchangeTransduction pathwaysColonic cryptsGenomic eventsCellular responsesKinase CG proteinsIsolated colonic cryptsConfocal laser imagingIntracellular receptorsTransepithelial electrolyte transportEpithelial ion transportNonepithelial tissuesHomeostatic regulationAldosterone applicationTraditional receptorsCentral roleIntracellular alkalizationIon transportReal-time imagingSteroid actionDirect Effects of Dopamine on Colonic Mucosal pH: Implications for Tonometry
Winter D, O'Sullivan G, Harvey B, Geibel J. Direct Effects of Dopamine on Colonic Mucosal pH: Implications for Tonometry. Journal Of Surgical Research 1999, 83: 62-68. PMID: 10210644, DOI: 10.1006/jsre.1998.5561.Peer-Reviewed Original ResearchConceptsSodium-hydrogen exchangeSplanchnic perfusionIntestinal mucosaLow-dose dopamine infusionBeta-adrenergic receptor blockadeEffects of dopamineSprague-Dawley ratsIntracellular calcium concentrationHepes-buffered Ringer's solutionMucosal crypt cellsFree cytosolic calciumCalcium-sensitive probeSplanchnic vasodilatorTonometric dataDopamine infusionMucosal effectsReceptor blockadeShocked patientsProtein kinase C inhibitionDistal colonGastric mucosaMucosal pHPharmacological agentsDirect effectTonometric measurements