2006
Somatostatin modulates PI3K-Akt, eNOS and NHE activity in the ciliary epithelium
Ghosh S, Choritz L, Geibel J, Coca-Prados M. Somatostatin modulates PI3K-Akt, eNOS and NHE activity in the ciliary epithelium. Molecular And Cellular Endocrinology 2006, 253: 63-75. PMID: 16764985, DOI: 10.1016/j.mce.2006.05.002.Peer-Reviewed Original ResearchConceptsP-Akt Ser473Ciliary epitheliumIntracellular cyclic GMP productionInvolvement of somatostatinDose-dependent attenuationReceptor mRNA expressionCyclic GMP productionSST-like immunoreactivityLack of responseOcular ciliary epitheliumAqueous humorSomatostatinNHE activityExchanger activityMRNA expressionCiliary processesNeuroendocrine cellsPC2 antibodyPI3K-AktMultiple intracellularGMP productionConvertases PC1Increases phosphorylationTissue extractsEpithelium
1994
The Mastomys Gastric Carcinoid: Aspects of Enterochromaff in-Like Cell Function
Modlin I, Lawton G, Tang L, Geibel J, Abraham R, Darr U. The Mastomys Gastric Carcinoid: Aspects of Enterochromaff in-Like Cell Function. Digestion 1994, 55: 31-37. PMID: 7535269, DOI: 10.1159/000201199.Peer-Reviewed Original ResearchConceptsECL cellsHistamine-1 receptor antagonistsGastric carcinoid tumorsCalcium-dependent mechanismBeta-adrenergic stimulationCarcinoid tumorsGastric carcinoidsReceptor antagonistHistamine secretionTumor growthLike cell functionCell functionGenetic propensitySecretionRegulation of growthMastomys rodentsCarcinoidsCellsMuscarinicPharmacotherapySomatostatinAntagonistTumorsHistamine