Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell
Kopic S, Wagner ME, Griessenauer C, Socrates T, Ritter M, Geibel JP. Vacuolar-type H+-ATPase-mediated proton transport in the rat parietal cell. Pflügers Archiv - European Journal Of Physiology 2011, 463: 419-427. PMID: 22146938, DOI: 10.1007/s00424-011-1060-0.Peer-Reviewed Original ResearchConceptsV-ATPase activityV-ATPaseAcid secretionParietal cellsRat parietal cellsProton pump inhibitor therapyCertain specialized cellsK-ATPaseProton transportVacuolar-type H-ATPaseK-ATPase inhibitionSecretion pathwayTrafficking mechanismsSpecialized cellsMicrotubule networkActive acidificationInhibitor therapyIntracellular organellesK-ATPase activityRat gastric glandsConcanamycin APharmacological inhibitionAcid loadIntracellular alkalinizationAcid breakthrough