2008
Resveratrol Inhibits Electrical Activity and Insulin Release from Insulinoma Cells by Block of Voltage-Gated Ca2+ Channels and Swelling-Dependent Cl- Currents
Jakab M, Lach S, Bacová Z, Langelüddecke C, Strbák V, Schmidt S, Iglseder E, Paulmichl M, Geibel J, Ritter M. Resveratrol Inhibits Electrical Activity and Insulin Release from Insulinoma Cells by Block of Voltage-Gated Ca2+ Channels and Swelling-Dependent Cl- Currents. Cellular Physiology And Biochemistry 2008, 22: 567-578. PMID: 19088439, DOI: 10.1159/000185541.Peer-Reviewed Original ResearchConceptsHigh extracellular glucoseElectrical activityInsulin releaseCl- currentBlock of VoltageWhole-cell patch-clamp experimentsPresence of iberiotoxinRat INS-1E cellsInsulinoma cellsMembrane depolarizationBasal insulin releaseGlucose-induced depolarizationExtracellular glucoseApplication of resveratrolCell membrane depolarizationPatch-clamp experimentsInsulin-Secreting CellsINS-1E cellsInsulin secretionRV doseAnimal modelsSecreting cellsInsulin responsivenessClamp experimentsResveratrol
1997
Surface dynamics in living acinar cells imaged by atomic force microscopy: Identification of plasma membrane structures involved in exocytosis
Schneider S, Sritharan K, Geibel J, Oberleithner H, Jena B. Surface dynamics in living acinar cells imaged by atomic force microscopy: Identification of plasma membrane structures involved in exocytosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 316-321. PMID: 8990206, PMCID: PMC19328, DOI: 10.1073/pnas.94.1.316.Peer-Reviewed Original ResearchConceptsAtomic force microscopePlasma membrane structureForce microscopeLive acinar cellsSecretory vesicle dockingPlasma membrane dynamicsAtomic force microscopyAcinar cellsMembrane structureVesicle dockingCompensatory endocytosisExocytic processForce microscopyFreeze-fracture electron microscopyMembrane dynamicsPlasma membraneFusion poreUltrahigh resolutionIsolated pancreatic acinar cellsPancreatic acinar cellsSurface dynamicsBasolateral regionStimulation of secretionLimited resolutionElectron microscopy