2020
Human Small Intestine Transplantation: Segmental Susceptibility to Ischemia Using Different Preservation Solutions and Conditions
Lysyy T, Finotti M, Maina RM, Morotti R, Munoz-Abraham AS, Bertacco A, Ibarra C, Barahona M, Agarwal R, D'Amico F, Rodriguez-Davalos MI, Mulligan D, Geibel J. Human Small Intestine Transplantation: Segmental Susceptibility to Ischemia Using Different Preservation Solutions and Conditions. Transplantation Proceedings 2020, 52: 2934-2940. PMID: 32768284, DOI: 10.1016/j.transproceed.2020.06.031.Peer-Reviewed Original ResearchConceptsContinuous perfusion preservationIntestinal graftIschemic damagePerfusion preservationAppropriate graft selectionCold static storageSmall intestinal graftsSmall intestine graftDifferent preservation solutionsBlinded histological evaluationCross clampIntestine graftsPostoperative complicationsDifferent time pointsIschemic injuryDeceased donorsPatient survivalGraft selectionRinger's lactateHistological evaluationBack tableVascular perfusionLuminal flushAbdominal organsSmall intestine
2019
The calcium‐sensing receptor: A novel target for treatment and prophylaxis of neratinib‐induced diarrhea
Lysyy T, Lalani AS, Olek EA, Diala I, Geibel JP. The calcium‐sensing receptor: A novel target for treatment and prophylaxis of neratinib‐induced diarrhea. Pharmacology Research & Perspectives 2019, 7: e00521. PMID: 31523434, PMCID: PMC6743423, DOI: 10.1002/prp2.521.Peer-Reviewed Original ResearchConceptsTyrosine kinase inhibitorsCaSR activationCalcium-sensing receptorDose-dependent mannerFluid secretionRat intestineHER2-positive breast cancerKinase inhibitorsAdverse effectsChemotherapy-associated diarrheaNeratinib-induced diarrheaCommon side effectsIsolated intestinal segmentsPotent therapeutic targetIrreversible panPatients' qualityBreast cancerIntestinal segmentsSide effectsTherapeutic targetDiarrheaPronounced elevationIntraluminal calcium concentrationVivo modelNeratinib
2014
A Novel Device to Preserve Intestinal Tissue Ex-Vivo by Cold Peristaltic Perfusion
Narayan RR, Pancer NE, Loeb BW, Oki K, Crouch A, Backus S, Chauhan Y, Patrón-Lozano R, Rodriguez-Davalos MI, Geibel JP, Fan RE, Zinter JP. A Novel Device to Preserve Intestinal Tissue Ex-Vivo by Cold Peristaltic Perfusion. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2014, 2014: 3118-3121. PMID: 25570651, DOI: 10.1109/embc.2014.6944283.Peer-Reviewed Original Research
2013
The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule
Capasso G, Geibel PJ, Damiano S, Jaeger P, Richards WG, Geibel JP. The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule. Kidney International 2013, 84: 277-284. PMID: 23615500, DOI: 10.1038/ki.2013.137.Peer-Reviewed Original ResearchMeSH KeywordsAcid-Base EquilibriumAnimalsCalcimimetic AgentsCalciumHydrogen-Ion ConcentrationIn Vitro TechniquesKidney Tubules, ProximalMaleMiceMice, KnockoutNuclear ProteinsPerfusionPuncturesRatsRats, Sprague-DawleyReceptors, Calcium-SensingReceptors, G-Protein-CoupledSodium-Hydrogen ExchangersTranscription FactorsConceptsProximal tubulesLuminal calcium concentrationFluid reabsorptionAcid secretionKnockout miceCalcium ion concentrationCalcium concentrationRole of CaSRActivation of CaSRCalcium sensing receptorCalcium-sensing receptorMouse proximal tubulesProton secretionSodium-hydrogen exchangerCalcimimetic agentBicarbonate absorptionSensing receptorCaSRFluid absorptionSecretionReabsorptionMiceCalcimimeticsTubulesLuminal membrane
2003
Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands
Kirchhoff P, Wagner CA, Gaetzschmann F, Radebold K, Geibel JP. Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands. AJP Gastrointestinal And Liver Physiology 2003, 285: g1242-g1248. PMID: 12907430, DOI: 10.1152/ajpgi.00165.2003.Peer-Reviewed Original ResearchAmilorideAnimalsBlotting, WesternCell MembraneEnzyme InhibitorsGastric MucosaGuanidinesH(+)-K(+)-Exchanging ATPaseHistamineHydrogen-Ion ConcentrationImmunohistochemistryIn Vitro TechniquesIntracellular MembranesIsoenzymesMethacrylatesOmeprazoleParietal Cells, GastricPerfusionRatsRats, Sprague-DawleySodium-Hydrogen Exchanger 3Sodium-Hydrogen Exchangers
2001
Na+-dependent fluid absorption in intact perfused rat colonic crypts
Geibel J, Rajendran V, Binder H. Na+-dependent fluid absorption in intact perfused rat colonic crypts. Gastroenterology 2001, 120: 144-150. PMID: 11208723, DOI: 10.1053/gast.2001.20890.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsBicarbonatesChloridesColonGanglionic StimulantsGlutamatesIn Vitro TechniquesIntestinal AbsorptionInulinIsotonic SolutionsMalePerfusionQuaternary Ammonium CompoundsRatsRats, Sprague-DawleyRinger's SolutionSodiumSodium-Hydrogen ExchangersTritiumConceptsNet fluid absorptionRat colonic cryptsCl- channel blockerFluid absorptionNeurohumoral stimulationChannel blockersColonic cryptsLumen ClAbsorptive processesInhibitor of NaCl(-) secretionAbstractTextCrypt cellsExchange inhibitorMicroperfusion techniqueFluid secretionL DIDSAmiloride analoguesMammalian colonSecretionAnion exchange inhibitorCryptsSignificant increaseAIMSSecretory process
1995
An apical permeability barrier to NH3/NH4+ in isolated, perfused colonic crypts.
Singh S, Binder H, Geibel J, Boron W. An apical permeability barrier to NH3/NH4+ in isolated, perfused colonic crypts. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 11573-11577. PMID: 8524806, PMCID: PMC40444, DOI: 10.1073/pnas.92.25.11573.Peer-Reviewed Original ResearchFluid absorption in isolated perfused colonic crypts.
Singh S, Binder H, Boron W, Geibel J. Fluid absorption in isolated perfused colonic crypts. Journal Of Clinical Investigation 1995, 96: 2373-2379. PMID: 7593625, PMCID: PMC185889, DOI: 10.1172/jci118294.Peer-Reviewed Original ResearchConceptsCrypt cellsNM vasoactive intestinal peptideFluid absorptionLarge intestinal functionColonic cryptsVasoactive intestinal peptideLamina propria cellsNet fluid secretionRat distal colonNet fluid absorptionDibutyryl cyclic AMPIntestinal peptideDistal colonIntestinal functionLamina propriaPathophysiological paradigmCrypt preparationMM acetylcholineBasal stateNeurohumoral agonistsFluid secretionCellular elementsEpithelial cellsIntestinal cryptsCrypts
1994
Unique Permeability Barrier of the Apical Surface of Parietal and Chief Cells in Isolated Perfused Gastric Glands
Boron W, Waisbren S, Modlin I, Geibel J. Unique Permeability Barrier of the Apical Surface of Parietal and Chief Cells in Isolated Perfused Gastric Glands. Journal Of Experimental Biology 1994, 196: 347-360. PMID: 7823033, DOI: 10.1242/jeb.196.1.347.Peer-Reviewed Original ResearchLuminal perfusion of isolated gastric glands
Waisbren S, Geibel J, Boron W, Modlin I. Luminal perfusion of isolated gastric glands. American Journal Of Physiology 1994, 266: c1013-c1027. PMID: 8178950, DOI: 10.1152/ajpcell.1994.266.4.c1013.Peer-Reviewed Original ResearchUnusual permeability properties of gastric gland cells
Waisbren S, Geibel J, Modlin I, Boron W. Unusual permeability properties of gastric gland cells. Nature 1994, 368: 332-335. PMID: 8127367, DOI: 10.1038/368332a0.Peer-Reviewed Original Research
1986
Effects of ouabain and temperature on cell membrane potentials in isolated perfused straight proximal tubules of the mouse kidney
Völkl H, Geibel J, Greger R, Lang F. Effects of ouabain and temperature on cell membrane potentials in isolated perfused straight proximal tubules of the mouse kidney. Pflügers Archiv - European Journal Of Physiology 1986, 407: 252-257. PMID: 3763371, DOI: 10.1007/bf00585299.Peer-Reviewed Original Research
1984
A microelectrode for continuous monitoring of glucose concentration in isolated perfused tubule segments
Rehwald W, Geibel J, Gstrein E, Oberleithner H. A microelectrode for continuous monitoring of glucose concentration in isolated perfused tubule segments. Pflügers Archiv - European Journal Of Physiology 1984, 400: 398-402. PMID: 6462888, DOI: 10.1007/bf00587539.Peer-Reviewed Original ResearchA microelectrode for continuous recording of volume fluxes in isolated perfused tubule segments
Geibel J, Völkl H, Lang F. A microelectrode for continuous recording of volume fluxes in isolated perfused tubule segments. Pflügers Archiv - European Journal Of Physiology 1984, 400: 388-392. PMID: 6462886, DOI: 10.1007/bf00587537.Peer-Reviewed Original ResearchA microelectrode for continuous monitoring of redox activity in isolated perfused tubule segments
Völkl H, Geibel J, Rehwald W, Lang F. A microelectrode for continuous monitoring of redox activity in isolated perfused tubule segments. Pflügers Archiv - European Journal Of Physiology 1984, 400: 393-397. PMID: 6462887, DOI: 10.1007/bf00587538.Peer-Reviewed Original Research