2005
An amino acid transporter involved in gastric acid secretion
Kirchhoff P, Dave MH, Remy C, Kosiek O, Busque SM, Dufner M, Geibel JP, Verrey F, Wagner CA. An amino acid transporter involved in gastric acid secretion. Pflügers Archiv - European Journal Of Physiology 2005, 451: 738-748. PMID: 16308696, DOI: 10.1007/s00424-005-1507-2.Peer-Reviewed Original ResearchConceptsAmino acid transportersAcid transportersAmino acidsHeteromeric amino acid transportersHeterodimeric amino acid transportersGastric acid secretionSystem L amino acid transportProtein-rich dietSystem L amino acid transportersSystem L aminoL amino acid transportersAmino acid transportParietal cellsAcid secretionPresence of glutamineNovel roleAcid transportVariety of stimuliIsolated rat gastric glandsTransportersATPase activityNon-metabolizable substratesSystem L.Serum amino acidsGlutamineThe B1-subunit of the H+ ATPase is required for maximal urinary acidification
Finberg KE, Wagner CA, Bailey MA, Păunescu T, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP. The B1-subunit of the H+ ATPase is required for maximal urinary acidification. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 13616-13621. PMID: 16174750, PMCID: PMC1224669, DOI: 10.1073/pnas.0506769102.Peer-Reviewed Original ResearchConceptsMaximal urinary acidificationNormal urinary acidificationMetabolic acidosisUrinary acidificationDistal renal tubular acidosisAcid challengeRenal tubular acidosisAcute intracellular acidificationB1 subunitLumen-negative potentialFurosemide infusionTubular acidosisAlkaline urineDistal nephronGreater severityAcidosisMiceLoss of B1Intracellular acidificationApical expressionUrineDuctFurther decreaseIsoformsPlasma membrane
2002
Acid-base transport in the collecting duct.
Wagner CA, Geibel JP. Acid-base transport in the collecting duct. Journal Of Nephrology 2002, 15 Suppl 5: s112-27. PMID: 12027210.Peer-Reviewed Original ResearchConceptsDistal renal tubular acidosisRisk of nephrocalcinosisAcid-base transportRenal tubular acidosisAngiotensin IIMetabolic acidosisTubular acidosisBicarbonate handlingElectrolyte statusRenal electrolyteMetabolic statusAcidosisFinal secretionDuctTranscellular movementProtein mutationsGenetic diseasesStatusBicarbonateAldosteroneCellsNephrocalcinosisEndothelinLithiasisSyndrome
1997
Differential activities of H+extrusion systems in MDCK cells due to extracellular osmolality and pH
Feifel E, Krall M, Geibel J, Pfaller W. Differential activities of H+extrusion systems in MDCK cells due to extracellular osmolality and pH. American Journal Of Physiology 1997, 273: f499-f506. PMID: 9362327, DOI: 10.1152/ajprenal.1997.273.4.f499.Peer-Reviewed Original Research
1994
Unique Permeability Barrier of the Apical Surface of Parietal and Chief Cells in Isolated Perfused Gastric Glands
Boron W, Waisbren S, Modlin I, Geibel J. Unique Permeability Barrier of the Apical Surface of Parietal and Chief Cells in Isolated Perfused Gastric Glands. Journal Of Experimental Biology 1994, 196: 347-360. PMID: 7823033, DOI: 10.1242/jeb.196.1.347.Peer-Reviewed Original Research