2007
PI3 Kinase Dependent Stimulation of Gastric Acid Secretion by Dexamethasone
Lang P, Schniepp R, Kirchhoff P, Socrates T, Sidani S, Geibel J. PI3 Kinase Dependent Stimulation of Gastric Acid Secretion by Dexamethasone. Cellular Physiology And Biochemistry 2007, 20: 527-534. PMID: 17762179, DOI: 10.1159/000107536.Peer-Reviewed Original ResearchMeSH KeywordsAndrostadienesAnimalsCimetidineDexamethasoneGastric AcidGastric MucosaH(+)-K(+)-Exchanging ATPaseMaleNitrobenzoatesPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPotassium Channel BlockersProtein Kinase InhibitorsProton Pump InhibitorsRatsRats, Sprague-DawleyStaurosporineWortmanninConceptsGastric acid secretionProtein kinase inhibitor staurosporinePI3-kinase inhibitor wortmanninAcid secretionKinase inhibitor staurosporineKinase inhibitor wortmanninPI3-kinase pathwayPeptic ulcerDexamethasone effectApical Cl- channelsKinase pathwayInhibitor wortmanninInhibitor staurosporineExcessive gastric acid secretionProton extrusionATPase inhibitor omeprazoleCl- channel blockers NPPBCl- channelsChannel blocker NPPBDependent stimulationDexamethasone injectionVivo pretreatmentInhibitor omeprazoleParietal cellsSecretion
1999
Rapid Effects of Aldosterone on Sodium-Hydrogen Exchange in Isolated Colonic Crypts
Winter D, Schneider M, O'Sullivan G, Harvey B, Geibel J. Rapid Effects of Aldosterone on Sodium-Hydrogen Exchange in Isolated Colonic Crypts. The Journal Of Membrane Biology 1999, 170: 17-26. PMID: 10398757, DOI: 10.1007/s002329900534.Peer-Reviewed Original ResearchMeSH KeywordsAldosteroneAmilorideAnimalsArachidonic AcidBicarbonatesColonDiureticsExtracellular SpaceFluoresceinsFluorescent DyesHydrogen-Ion ConcentrationIon ExchangeIon TransportLeukotriene AntagonistsMaleMineralocorticoid Receptor AntagonistsPhospholipasesProstaglandin AntagonistsProtein BiosynthesisProtein Kinase InhibitorsProtein KinasesProtein Synthesis InhibitorsRatsRats, Sprague-DawleySodiumSodium-Hydrogen ExchangersSpironolactoneTranscription, GeneticConceptsProtein synthesisRapid cellular responsesSignal transduction pathwaysProtein kinase CSodium-hydrogen exchangeTransduction pathwaysColonic cryptsGenomic eventsCellular responsesKinase CG proteinsIsolated colonic cryptsConfocal laser imagingIntracellular receptorsTransepithelial electrolyte transportEpithelial ion transportNonepithelial tissuesHomeostatic regulationAldosterone applicationTraditional receptorsCentral roleIntracellular alkalizationIon transportReal-time imagingSteroid action