2002
Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status
Wagner CA, Finberg KE, Stehberger PA, Lifton RP, Giebisch GH, Aronson PS, Geibel JP. Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status. Kidney International 2002, 62: 2109-2117. PMID: 12427135, DOI: 10.1046/j.1523-1755.2002.00671.x.Peer-Reviewed Original ResearchConceptsPendrin-positive cellsAcid-base statusPositive cellsBicarbonate secretionMouse kidneyAcid-base transportKnockout mouse modelProtein expression levelsMetabolic alkalosisDeficient dietExchanger pendrinPendrin expressionMouse modelSensorineural deafnessThyroid glandBicarbonate loadPendred syndromeWestern blottingApical membraneInner earPendrin proteinControl levelsKidneyPendrinProtein levels
2000
Calcium, ATP and nuclear pore channel gating
Bustamante J, Michelette E, Geibel J, Dean D, Hanover J, McDonnell T. Calcium, ATP and nuclear pore channel gating. Pflügers Archiv - European Journal Of Physiology 2000, 439: 433-444. PMID: 10678739, PMCID: PMC4400178, DOI: 10.1007/s004249900189.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAntibodies, MonoclonalBiological TransportCalciumCalcium ChannelsChelating AgentsCytosolDextransEgtazic AcidEndoplasmic ReticulumEnzyme InhibitorsFluorescein-5-isothiocyanateFluorescent DyesGene Expression Regulation, NeoplasticInositol 1,4,5-TrisphosphateIon Channel GatingMaleNuclear EnvelopeOocytesPatch-Clamp TechniquesProstatic NeoplasmsThapsigarginTumor Cells, CulturedXenopus laevisConceptsNPC channelGene activityChannel gatingMacromolecular transportCytosolic Ca2Fluorescence microscopy observationsTranscription factorsNE membranesProstate cancer cellsCytosolic ATPIntracellular messengerCellular rhythmsRole of Ca2ATPCancer cellsPatch-clamp studiesPresent patch-clamp studyRNAIon channel behaviorRegulationCardiomyocyte nucleiGatingExpressionCa2Thapsigargin
1999
Direct Effects of Dopamine on Colonic Mucosal pH: Implications for Tonometry
Winter D, O'Sullivan G, Harvey B, Geibel J. Direct Effects of Dopamine on Colonic Mucosal pH: Implications for Tonometry. Journal Of Surgical Research 1999, 83: 62-68. PMID: 10210644, DOI: 10.1006/jsre.1998.5561.Peer-Reviewed Original ResearchConceptsSodium-hydrogen exchangeSplanchnic perfusionIntestinal mucosaLow-dose dopamine infusionBeta-adrenergic receptor blockadeEffects of dopamineSprague-Dawley ratsIntracellular calcium concentrationHepes-buffered Ringer's solutionMucosal crypt cellsFree cytosolic calciumCalcium-sensitive probeSplanchnic vasodilatorTonometric dataDopamine infusionMucosal effectsReceptor blockadeShocked patientsProtein kinase C inhibitionDistal colonGastric mucosaMucosal pHPharmacological agentsDirect effectTonometric measurements