2019
The calcium‐sensing receptor: A novel target for treatment and prophylaxis of neratinib‐induced diarrhea
Lysyy T, Lalani AS, Olek EA, Diala I, Geibel JP. The calcium‐sensing receptor: A novel target for treatment and prophylaxis of neratinib‐induced diarrhea. Pharmacology Research & Perspectives 2019, 7: e00521. PMID: 31523434, PMCID: PMC6743423, DOI: 10.1002/prp2.521.Peer-Reviewed Original ResearchConceptsTyrosine kinase inhibitorsCaSR activationCalcium-sensing receptorDose-dependent mannerFluid secretionRat intestineHER2-positive breast cancerKinase inhibitorsAdverse effectsChemotherapy-associated diarrheaNeratinib-induced diarrheaCommon side effectsIsolated intestinal segmentsPotent therapeutic targetIrreversible panPatients' qualityBreast cancerIntestinal segmentsSide effectsTherapeutic targetDiarrheaPronounced elevationIntraluminal calcium concentrationVivo modelNeratinib
2010
Toxin Mediated Diarrhea in the 21st Century: The Pathophysiology of Intestinal Ion Transport in the Course of ETEC, V. cholerae and Rotavirus Infection
Kopic S, Geibel JP. Toxin Mediated Diarrhea in the 21st Century: The Pathophysiology of Intestinal Ion Transport in the Course of ETEC, V. cholerae and Rotavirus Infection. Toxins 2010, 2: 2132-2157. PMID: 22069677, PMCID: PMC3153279, DOI: 10.3390/toxins2082132.Peer-Reviewed Original ResearchConceptsEpisodes of diarrheaIntestinal ion transportSpecific therapeutic approachesMajor healthcare concernRotavirus infectionTherapeutic approachesV. choleraeCommon enterotoxinInfectious agentsPathophysiological processesInfectious diseasesDiarrheaHealthcare concernCellular mechanismsLethal effectsPathophysiologyYearsInfectionCholeraeRotavirusDiseaseETECEvidence for intestinal chloride secretion
Murek M, Kopic S, Geibel J. Evidence for intestinal chloride secretion. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2010, 95: 471-478. PMID: 20233891, DOI: 10.1113/expphysiol.2009.049445.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChloride ChannelsChloridesCLC-2 Chloride ChannelsCystic Fibrosis Transmembrane Conductance RegulatorDiarrheaEnterocytesHumansIntestinal AbsorptionIntestinal MucosaIntestinal SecretionsPotassium ChannelsSodium-Potassium-Chloride SymportersSodium-Potassium-Exchanging ATPaseTight JunctionsWater-Electrolyte BalanceCommentary on ‘Diarrhoeal disease through enterocyte secretion: a doctrine untroubled by proof’
Kopic S, Murek M, Geibel JP. Commentary on ‘Diarrhoeal disease through enterocyte secretion: a doctrine untroubled by proof’. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2010, 95: 484-485. PMID: 20233894, DOI: 10.1113/expphysiol.2009.051912.Peer-Reviewed Original Research
2005
Bicarbonate Secretion
Binder HJ, Rajendran V, Sadasivan V, Geibel JP. Bicarbonate Secretion. Journal Of Clinical Gastroenterology 2005, 39: s53-s58. PMID: 15758660, DOI: 10.1097/01.mcg.0000155521.81382.3a.Peer-Reviewed Original Research