2010
Ethanol Inhibits Gastric Acid Secretion in Rats Through Increased AMP-Kinase Activity
Kopic S, Corradini S, Sidani S, Murek M, Vardanyan A, Föller M, Ritter M, Geibel JP. Ethanol Inhibits Gastric Acid Secretion in Rats Through Increased AMP-Kinase Activity. Cellular Physiology And Biochemistry 2010, 25: 195-202. PMID: 20110680, DOI: 10.1159/000276553.Peer-Reviewed Original ResearchConceptsGastric acid secretionAcid secretionSecretagogue-induced acid secretionInhibits gastric acid secretionShort-term ethanol exposurePH-sensitive dye BCECFLow-dose ethanolCompound CAMPK inhibitor compound CSpecific AMPK inhibitor compound CEffects of ethanolInhibitor compound CEthanol exposureRat gastric glandsActivation of AMPKInteraction of ethanolRat gastric parietal cellsFluorescence digital imagingGastric parietal cellsAMP kinase activityDye BCECFInhibitory effectSecretionParietal cellsAMPK pathway
2003
Characterization of Cl-HCO3 exchange in basolateral membrane of rat distal colon
Ikuma M, Geibel J, Binder HJ, Rajendran VM. Characterization of Cl-HCO3 exchange in basolateral membrane of rat distal colon. American Journal Of Physiology - Cell Physiology 2003, 285: c912-c921. PMID: 12826602, DOI: 10.1152/ajpcell.00396.2002.Peer-Reviewed Original ResearchConceptsRat distal colonCl-HCO3 exchangeDistal colonBasolateral membraneHalf-maximal inhibitory constantsBasolateral membrane vesiclesCl- channel blockerColonic epithelial cellsAbsence of HCO3Channel blockersRat colonic epithelial cellsCrypt preparationCrypt cellsExchange inhibitorCl-OH exchangeRemoval of ClColonEpithelial cellsAnion exchange inhibitorHCO3- gradientProtease inhibitorsK ionophorePresent studyInhibitory constantsProtease inhibitor cocktail
1999
Rapid Effects of Aldosterone on Sodium-Hydrogen Exchange in Isolated Colonic Crypts
Winter D, Schneider M, O'Sullivan G, Harvey B, Geibel J. Rapid Effects of Aldosterone on Sodium-Hydrogen Exchange in Isolated Colonic Crypts. The Journal Of Membrane Biology 1999, 170: 17-26. PMID: 10398757, DOI: 10.1007/s002329900534.Peer-Reviewed Original ResearchMeSH KeywordsAldosteroneAmilorideAnimalsArachidonic AcidBicarbonatesColonDiureticsExtracellular SpaceFluoresceinsFluorescent DyesHydrogen-Ion ConcentrationIon ExchangeIon TransportLeukotriene AntagonistsMaleMineralocorticoid Receptor AntagonistsPhospholipasesProstaglandin AntagonistsProtein BiosynthesisProtein Kinase InhibitorsProtein KinasesProtein Synthesis InhibitorsRatsRats, Sprague-DawleySodiumSodium-Hydrogen ExchangersSpironolactoneTranscription, GeneticConceptsProtein synthesisRapid cellular responsesSignal transduction pathwaysProtein kinase CSodium-hydrogen exchangeTransduction pathwaysColonic cryptsGenomic eventsCellular responsesKinase CG proteinsIsolated colonic cryptsConfocal laser imagingIntracellular receptorsTransepithelial electrolyte transportEpithelial ion transportNonepithelial tissuesHomeostatic regulationAldosterone applicationTraditional receptorsCentral roleIntracellular alkalizationIon transportReal-time imagingSteroid action
1997
Intracellular Acidification Induces Cl/HCO3 Exchange Activity in the Basolateral Membrane of β-intercalated Cells of the Rabbit Cortical Collecting Duct
Merot J, Giebisch G, Geibel J. Intracellular Acidification Induces Cl/HCO3 Exchange Activity in the Basolateral Membrane of β-intercalated Cells of the Rabbit Cortical Collecting Duct. The Journal Of Membrane Biology 1997, 159: 253-262. PMID: 9312214, DOI: 10.1007/s002329900288.Peer-Reviewed Original ResearchConceptsBeta-intercalated cellsCortical collecting ductsRabbit cortical collecting ductsHCO3- exchange activityAcid-base transportersProfound decreaseChloride-bicarbonate exchangerCollecting ductsBasolateral additionBasolateral DIDSPH recoveryApical applicationIntracellular pHCell pHDifferent lag periodsBasolateral membraneCellsDuctAcid loading
1995
An apical permeability barrier to NH3/NH4+ in isolated, perfused colonic crypts.
Singh S, Binder H, Geibel J, Boron W. An apical permeability barrier to NH3/NH4+ in isolated, perfused colonic crypts. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 11573-11577. PMID: 8524806, PMCID: PMC40444, DOI: 10.1073/pnas.92.25.11573.Peer-Reviewed Original Research
1994
Unusual permeability properties of gastric gland cells
Waisbren S, Geibel J, Modlin I, Boron W. Unusual permeability properties of gastric gland cells. Nature 1994, 368: 332-335. PMID: 8127367, DOI: 10.1038/368332a0.Peer-Reviewed Original Research