2006
The KCNE2 Potassium Channel Ancillary Subunit Is Essential for Gastric Acid Secretion*
Roepke TK, Anantharam A, Kirchhoff P, Busque SM, Young JB, Geibel JP, Lerner DJ, Abbott GW. The KCNE2 Potassium Channel Ancillary Subunit Is Essential for Gastric Acid Secretion*. Journal Of Biological Chemistry 2006, 281: 23740-23747. PMID: 16754665, DOI: 10.1074/jbc.m604155200.Peer-Reviewed Original ResearchConceptsAncillary subunitsKCNE gene familyGastric acid secretionPotassium channel alpha subunitFirst genetic evidenceSecretory cellsProton secretionChannel alpha subunitGene familyKCNE familyParietal cell morphologyAcid secretionGenetic evidenceAlpha subunitHuman cardiac arrhythmiasParietal cellsChannel complexSubunitsCell morphologyKCNE2Normal gastrointestinal functionGenesKCNQ1Gene-dose effectCells
1995
Gastrin-stimulated changes in Ca2+ concentration in parietal cells depends on adenosine 3′,5′-cyclic monophosphate levels
Geibel J, Abraham R, Modlin I, Sachs G. Gastrin-stimulated changes in Ca2+ concentration in parietal cells depends on adenosine 3′,5′-cyclic monophosphate levels. Gastroenterology 1995, 109: 1060-1067. PMID: 7557070, DOI: 10.1016/0016-5085(95)90563-4.Peer-Reviewed Original ResearchConceptsCyclic monophosphate (cAMP) levelsParietal cellsECL cellsIntracellular calcium concentration ([Ca2+]i) responseMonophosphate levelsECL-cell responseGastric glandsFunction of adenosineGastrin/cholecystokinin B receptorCholecystokinin B receptorCyclic monophosphate (cAMP) pathwayParietal cell functionAddition of gastrinH2 receptor activityEffect of gastrinIsolated gastric glandsSecretory receptorCell responsesGastrinReceptor activityAbstractTextB receptorCell functionIntracellular adenosineAIMS