2008
Resveratrol Inhibits Electrical Activity and Insulin Release from Insulinoma Cells by Block of Voltage-Gated Ca2+ Channels and Swelling-Dependent Cl- Currents
Jakab M, Lach S, Bacová Z, Langelüddecke C, Strbák V, Schmidt S, Iglseder E, Paulmichl M, Geibel J, Ritter M. Resveratrol Inhibits Electrical Activity and Insulin Release from Insulinoma Cells by Block of Voltage-Gated Ca2+ Channels and Swelling-Dependent Cl- Currents. Cellular Physiology And Biochemistry 2008, 22: 567-578. PMID: 19088439, DOI: 10.1159/000185541.Peer-Reviewed Original ResearchConceptsHigh extracellular glucoseElectrical activityInsulin releaseCl- currentBlock of VoltageWhole-cell patch-clamp experimentsPresence of iberiotoxinRat INS-1E cellsInsulinoma cellsMembrane depolarizationBasal insulin releaseGlucose-induced depolarizationExtracellular glucoseApplication of resveratrolCell membrane depolarizationPatch-clamp experimentsInsulin-Secreting CellsINS-1E cellsInsulin secretionRV doseAnimal modelsSecreting cellsInsulin responsivenessClamp experimentsResveratrol
1993
Endothelin increases [Ca2+]i in M-1 mouse cortical collecting duct cells by a dual mechanism
Korbmacher C, Boulpaep E, Giebisch G, Geibel J. Endothelin increases [Ca2+]i in M-1 mouse cortical collecting duct cells by a dual mechanism. American Journal Of Physiology 1993, 265: c349-c357. PMID: 8368264, DOI: 10.1152/ajpcell.1993.265.2.c349.Peer-Reviewed Original ResearchConceptsEndothelin-1Intracellular storesDuct cellsNifedipine-sensitive Ca2Intracellular calcium concentrationParticipation of Ca2Endothelin increaseFura-2Extracellular calciumExtracellular Ca2Arginine vasopressinIntracellular Ca2Calcium concentrationInitial Ca2Fluorescent imaging systemInitial exposurePlateau phaseMiceEntry mechanismDual mechanismCa2Second Ca2CellsNifedipineVasopressin