2010
Zinc Salts Provide a Novel, Prolonged and Rapid Inhibition of Gastric Acid Secretion
Kirchhoff P, Socrates T, Sidani S, Duffy A, Breidthardt T, Grob C, Viehl CT, Beglinger C, Oertli D, Geibel JP. Zinc Salts Provide a Novel, Prolonged and Rapid Inhibition of Gastric Acid Secretion. The American Journal Of Gastroenterology 2010, 106: 62. PMID: 20736941, DOI: 10.1038/ajg.2010.327.Peer-Reviewed Original ResearchConceptsProton pump inhibitorsGastric acid secretionAcid secretionRat gastric glandsRandomized cross-over studyIntact rat stomachAcid suppression therapyGastric glandsCross-over studyOnset of actionLong-term efficacyReturn of symptomsHealthy human volunteersSecretagogue-induced acid secretionStomach acid secretionProlonged therapySuppression therapyIntragastric pHPump inhibitorsSingle doseWhole stomachLifetime prevalenceRat modelRat stomachFaster onset
2006
Characteristics of the K+-competitive H+,K+-ATPase inhibitor AZD0865 in isolated rat gastric glands
Kirchhoff P, Andersson K, Socrates T, Sidani S, Kosiek O, Geibel J. Characteristics of the K+-competitive H+,K+-ATPase inhibitor AZD0865 in isolated rat gastric glands. AJP Gastrointestinal And Liver Physiology 2006, 291: g838-g843. PMID: 16798725, DOI: 10.1152/ajpgi.00120.2006.Peer-Reviewed Original ResearchConceptsGastric acid secretionAcid secretionRat gastric glandsPotassium-competitive acid blockerGastric glandsPeptic ulcer diseaseProton pump inhibitor omeprazoleAcid-related diseasesCompetitive acid blockerPresence of omeprazoleLow-dose inhibitorsFree perfusateUlcer diseasePharmacological treatmentAZD0865High success rateAcid blockerLow doseRapid onsetSensitive dye BCECFInhibitor omeprazoleAcid loadOmeprazoleDye BCECFSecretion
2005
An amino acid transporter involved in gastric acid secretion
Kirchhoff P, Dave MH, Remy C, Kosiek O, Busque SM, Dufner M, Geibel JP, Verrey F, Wagner CA. An amino acid transporter involved in gastric acid secretion. Pflügers Archiv - European Journal Of Physiology 2005, 451: 738-748. PMID: 16308696, DOI: 10.1007/s00424-005-1507-2.Peer-Reviewed Original ResearchConceptsAmino acid transportersAcid transportersAmino acidsHeteromeric amino acid transportersHeterodimeric amino acid transportersGastric acid secretionSystem L amino acid transportProtein-rich dietSystem L amino acid transportersSystem L aminoL amino acid transportersAmino acid transportParietal cellsAcid secretionPresence of glutamineNovel roleAcid transportVariety of stimuliIsolated rat gastric glandsTransportersATPase activityNon-metabolizable substratesSystem L.Serum amino acidsGlutaminel-Type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells
Busque SM, Kerstetter JE, Geibel JP, Insogna K. l-Type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells. AJP Gastrointestinal And Liver Physiology 2005, 289: g664-g669. PMID: 15961860, DOI: 10.1152/ajpgi.00096.2005.Peer-Reviewed Original ResearchConceptsCalcium-sensing receptorAbsence of secretagoguesAcid secretionParietal cellsHistamine-2 receptorSystem L amino acid transportGastric acid secretionWhole stomach preparationDose-dependent increaseIndividual parietal cellsStomach preparationRat gastric glandsHEK-293 cellsCaSRL-amino acidsGastric glandsHormonal stimulationATPase activitySecretionPhysiological concentrationsReceptorsSecretagoguesAcid transportAmino acidsSecretory cells
2003
Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands
Kirchhoff P, Wagner CA, Gaetzschmann F, Radebold K, Geibel JP. Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands. AJP Gastrointestinal And Liver Physiology 2003, 285: g1242-g1248. PMID: 12907430, DOI: 10.1152/ajpgi.00165.2003.Peer-Reviewed Original ResearchAmilorideAnimalsBlotting, WesternCell MembraneEnzyme InhibitorsGastric MucosaGuanidinesH(+)-K(+)-Exchanging ATPaseHistamineHydrogen-Ion ConcentrationImmunohistochemistryIn Vitro TechniquesIntracellular MembranesIsoenzymesMethacrylatesOmeprazoleParietal Cells, GastricPerfusionRatsRats, Sprague-DawleySodium-Hydrogen Exchanger 3Sodium-Hydrogen Exchangers
2001
The Stomach Divalent Ion-sensing Receptor SCAR Is a Modulator of Gastric Acid Secretion*
Geibel J, Wagner C, Caroppo R, Qureshi I, Gloeckner J, Manuelidis L, Kirchhoff P, Radebold K. The Stomach Divalent Ion-sensing Receptor SCAR Is a Modulator of Gastric Acid Secretion*. Journal Of Biological Chemistry 2001, 276: 39549-39552. PMID: 11507103, DOI: 10.1074/jbc.m107315200.Peer-Reviewed Original ResearchConceptsDivalent cation receptorsTransport proteinsPlasma membrane transport proteinsMembrane transport proteinsGastric acid secretionGastric parietal cellsParietal cellsExact functionNovel pathwayGastric glandsReceptor familySecretory cellsAcid secretionCalcium-sensing receptorBasolateral membranePathwayEndocrine pathwaysExtracellular cationsProteinNew insightsATPaseRat gastric glandsRegulationCellsDivalent cations