2024
The role of genetics on behavioral outcomes in nonsyndromic sagittal synostosis.
Alper D, Almeida M, Hu K, Yang J, Timberlake A, Shah J, Persing J, Alperovich M. The role of genetics on behavioral outcomes in nonsyndromic sagittal synostosis. Journal Of Neurosurgery Pediatrics 2024, 34: 234-245. PMID: 38875721, DOI: 10.3171/2024.4.peds23510.Peer-Reviewed Original ResearchBehavioral outcomesNonsyndromic sagittal synostosisSocial Responsiveness Scale-2nd editionBehavior Rating InventoryAttention-deficit/hyperactivity disorderSagittal synostosisPly geneRelative to controlsExecutive functionAttention-deficit/hyperactivityExternalizing behaviorsExternalizing problemsLoss of functionBehavior problemsASD domainAssociated with worse scoresOutcomes of patientsRule-breakingParents of children aged 6Treating sagittal synostosisOlder ageAssociation of mutationsBehavior scoresSociodemographic factorsPly groups
2023
Quantifying the Impact of Genetics on Neurocognition in Nonsyndromic Sagittal Craniosynostosis
Junn A, Dinis J, Long A, Timberlake A, Persing J, Alperovich M. Quantifying the Impact of Genetics on Neurocognition in Nonsyndromic Sagittal Craniosynostosis. Plastic & Reconstructive Surgery 2023, 152: 300e-306e. PMID: 36912936, DOI: 10.1097/prs.0000000000010400.Peer-Reviewed Original ResearchConceptsFull-scale intelligence quotientHigh-risk mutationsNonsyndromic craniosynostosisNeurocognitive outcomesDouble-blinded cohort studySignificant differencesCLINICAL QUESTION/LEVELVisuomotor integrationTime of surgeryType of surgeryHigh-risk genotypesPoor neurocognitive outcomesNonsyndromic sagittal craniosynostosisHigh-risk genesPresence of mutationsCohort studySurgery typePatient factorsNeurodevelopmental delayAnalysis of covarianceNeurocognitive testingNeurocognitive effectsPatientsSociodemographic factorsSagittal craniosynostosis