2023
Quantifying the Impact of Genetics on Neurocognition in Nonsyndromic Sagittal Craniosynostosis
Junn A, Dinis J, Long A, Timberlake A, Persing J, Alperovich M. Quantifying the Impact of Genetics on Neurocognition in Nonsyndromic Sagittal Craniosynostosis. Plastic & Reconstructive Surgery 2023, 152: 300e-306e. PMID: 36912936, DOI: 10.1097/prs.0000000000010400.Peer-Reviewed Original ResearchConceptsFull-scale intelligence quotientHigh-risk mutationsNonsyndromic craniosynostosisNeurocognitive outcomesDouble-blinded cohort studySignificant differencesCLINICAL QUESTION/LEVELVisuomotor integrationTime of surgeryType of surgeryHigh-risk genotypesPoor neurocognitive outcomesNonsyndromic sagittal craniosynostosisHigh-risk genesPresence of mutationsCohort studySurgery typePatient factorsNeurodevelopmental delayAnalysis of covarianceNeurocognitive testingNeurocognitive effectsPatientsSociodemographic factorsSagittal craniosynostosisLong-term neurocognitive outcomes in 204 single-suture craniosynostosis patients
Junn A, Long A, Hauc S, Almeida M, Alper D, Rivera J, Mayes L, Persing J, Alperovich M. Long-term neurocognitive outcomes in 204 single-suture craniosynostosis patients. Child's Nervous System 2023, 39: 1921-1928. PMID: 36877207, DOI: 10.1007/s00381-023-05908-1.Peer-Reviewed Original ResearchConceptsFull Scale IQVisuomotor integrationVisual perceptionVerbal IQNeurocognitive testingVisual perception scoresHigher scoresLong-term neurocognitive outcomesCognitive profileWhite matter connectionsNeurocognitive deficitsIQPerception scoresMean IQNeurocognitive outcomesFrontal lobeLower scoresMotor controlMotor coordinationPerceptionNon-syndromic craniosynostosisUnicoronal synostosisScoresChildren 6Neurocognitive Outcomes in Deformational Plagiocephaly: Is There an Association between Morphologic Severity and Results?
Park K, Chandler L, Ahmad M, Singh A, Allam O, Mets E, Bridgett D, Persing J, Alperovich M. Neurocognitive Outcomes in Deformational Plagiocephaly: Is There an Association between Morphologic Severity and Results? Plastic & Reconstructive Surgery 2023, 152: 488e-498e. PMID: 36847664, DOI: 10.1097/prs.0000000000010330.Peer-Reviewed Original ResearchConceptsNeurocognitive outcomesHelmet therapyDeformational plagiocephalyNeurocognitive functionLong-term neurocognitive functionCLINICAL QUESTION/LEVELLong-term neurocognitive outcomesWorse neurocognitive outcomesVisual-motor functionMotor coordination scoresHead shape abnormalitiesSeverity of plagiocephalyNeurodevelopmental effectsSchool-aged childrenDP cohortMotor coordinationSignificant lateralityGaps in Access to Reconstruction Compared with Audiologic Care among Children with Microtia
Long A, Junn A, Shah H, Almeida M, Rivera J, Nguyen H, Persing J, Alperovich M. Gaps in Access to Reconstruction Compared with Audiologic Care among Children with Microtia. The Journal Of Pediatrics 2023, 262: 113340. PMID: 36736584, DOI: 10.1016/j.jpeds.2023.01.014.Peer-Reviewed Original Research
2022
Cerebral Blood Flow of the Frontal Lobe in Untreated Children with Trigonocephaly versus Healthy Controls: An Arterial Spin Labeling Study
Long A, Persing J, Alperovich M. Cerebral Blood Flow of the Frontal Lobe in Untreated Children with Trigonocephaly versus Healthy Controls: An Arterial Spin Labeling Study. Plastic & Reconstructive Surgery 2022, 151: 526e-527e. PMID: 36730155, DOI: 10.1097/prs.0000000000009946.Peer-Reviewed Original ResearchLongitudinal Outpatient and School-Based Service Use among Children with Nonsyndromic Craniosynostosis
Peck CJ, Junn A, Park KE, Khetpal S, Cabrejo R, Singh A, Mayes L, Alperovich M, Persing J. Longitudinal Outpatient and School-Based Service Use among Children with Nonsyndromic Craniosynostosis. Plastic & Reconstructive Surgery 2022, 150: 1309-1317. PMID: 36126215, DOI: 10.1097/prs.0000000000009678.Peer-Reviewed Original ResearchConceptsLongitudinal needsNonsyndromic craniosynostosisParents of childrenService useSchool-based servicesAfrican American race/ethnicityTime of surgerySupportive servicesPercent of parentsPredictive variablesSignificant predictive variablesType of interventionRace/ethnicityNeurodevelopmental sequelaeMale sexMajority of parentsSchool-aged childrenUse of servicesPhysical therapyPresence of siblingsSignificant burdenOutpatientsHigh parental incomeMultifactorial natureSagittal synostosis
2020
Nasopharyngeal airway and subcranial space analysis in Pfeiffer syndrome
Lu X, Forte A, Allam O, Park K, Junn A, Alperovich M, Steinbacher D, Tonello C, Alonso N, Persing J. Nasopharyngeal airway and subcranial space analysis in Pfeiffer syndrome. British Journal Of Oral And Maxillofacial Surgery 2020, 59: 592-598. PMID: 33863588, DOI: 10.1016/j.bjoms.2020.10.008.Peer-Reviewed Original ResearchConceptsAirway volumeNasal airwayPfeiffer syndromeNasopharyngeal airwayPharyngeal airwayComputed tomogramsCross-sectional areaPharyngeal airway volumeNasal airway volumePreoperative computed tomogramsMaxillomandibular advancementRespiratory crisisSurgical treatmentUpper airwayChoanal stenosisAirwayPatientsNasal pathwayMaxillary expansionRegional abnormalitiesSyndromeAnteroposterior dimensionAnatomical basisAnteroposterior lengthPosterior width
2019
Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis
Timberlake AT, Jin SC, Nelson-Williams C, Wu R, Furey CG, Islam B, Haider S, Loring E, Galm A, Steinbacher D, Larysz D, Staffenberg D, Flores R, Rodriguez E, Boggon T, Persing J, Lifton R, Lifton RP, Gunel M, Mane S, Bilguvar K, Gerstein M, Loring E, Nelson-Williams C, Lopez F, Knight J. Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 15116-15121. PMID: 31292255, PMCID: PMC6660739, DOI: 10.1073/pnas.1902041116.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlpha CateninChildChild, PreschoolCraniosynostosesExomeExome SequencingFemaleGene ExpressionGlypicansHistone AcetyltransferasesHumansMaleMutationNuclear ProteinsPedigreeRisk AssessmentSignal TransductionSkullSOXC Transcription FactorsTranscription Factor AP-2Zinc Finger Protein Gli2ConceptsRare damaging mutationsSyndromic craniosynostosisCongenital anomaliesDamaging mutationsSyndromic casesExome sequencingAdditional congenital anomaliesFrequent congenital anomaliesDamaging de novo mutationsNeural crest cell migrationDamaging de novoCrest cell migrationCS patientsMutation burdenChromatin modifiersSubsequent childrenTranscription factorsDe novo mutationsCS casesCS geneHedgehog pathwayDisease locusPremature fusionFunction mutationsCraniosynostosis
2017
De novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis
Timberlake AT, Furey CG, Choi J, Nelson-Williams C, Loring E, Galm A, Kahle K, Steinbacher D, Larysz D, Persing J, Lifton R, Bilguvar K, Mane S, Tikhonova I, Castaldi C, Knight J. De novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e7341-e7347. PMID: 28808027, PMCID: PMC5584457, DOI: 10.1073/pnas.1709255114.Peer-Reviewed Original ResearchConceptsBone morphogenetic proteinRas/ERKDe novo mutationsNovo mutationsRas/ERK pathwayDamaging de novo mutationsHigh locus heterogeneityRare syndromic diseaseCommon risk variantsInhibitor of WntSyndromic craniosynostosesNew genesParent-offspring triosSyndromic diseaseMorphogenetic proteinsNegative regulatorERK pathwayMore cranial suturesGenesMidline craniosynostosisRisk variantsWntLocus heterogeneityMutationsExome sequencing
2014
The Impact of Age at Surgery on Long-Term Neuropsychological Outcomes in Sagittal Craniosynostosis
Patel A, Yang JF, Hashim PW, Travieso R, Terner J, Mayes LC, Kanev P, Duncan C, Jane J, Jane J, Pollack I, Losee JE, Bridgett DJ, Persing JA. The Impact of Age at Surgery on Long-Term Neuropsychological Outcomes in Sagittal Craniosynostosis. Plastic & Reconstructive Surgery 2014, 134: 608e-617e. PMID: 25357055, DOI: 10.1097/prs.0000000000000511.Peer-Reviewed Original ResearchConceptsLong-term neuropsychological outcomesWhole-vault cranioplastyNeuropsychological outcomesLong-term cognitive functioningHigher full-scale IQReading-related learning disabilitiesFull Scale IQWord readingCognitive functioningNeuropsychological measuresVerbal IQImproved long-term neurological outcomeNeuropsychological functionLearning DisabilitiesSagittal suture craniosynostosisIQNeurodevelopmental testsImpact of ageStrip craniectomyLong-term neurological outcomeNumerical operationsCLINICAL QUESTION/LEVELSuperior abilityTime of surgeryTechnique of surgery
2001
A Preliminary Report of the Virtual Craniofacial Center: Development of Internet-/Intranet-Based Care Coordination of Pediatric Craniofacial Patients
Goodwin M, Otake L, Persing J, Shin J. A Preliminary Report of the Virtual Craniofacial Center: Development of Internet-/Intranet-Based Care Coordination of Pediatric Craniofacial Patients. Annals Of Plastic Surgery 2001, 46: 511-516. PMID: 11352425, DOI: 10.1097/00000637-200105000-00010.Peer-Reviewed Original ResearchConceptsPersonal computer systemArchival data storageRemote databaseUnique identification numberComputer systemsTextual dataData storageWeb sitesDigital cameraPassword accessDigital photographic imagesEconomical equipmentManagement dataIdentification numberPhotographic imagesStandardized imagesCurrent systemImagesLine connectionDatabaseServerLong-term goalTeam membersConfidentialityPatient database
1998
Intracranial Pressure in Single-Suture Craniosynostosis
Cohen S, Persing J. Intracranial Pressure in Single-Suture Craniosynostosis. The Cleft Palate-Craniofacial Journal 1998, 35: 194-196. DOI: 10.1597/1545-1569(1998)035<0194:ipissc>2.3.co;2.Peer-Reviewed Original ResearchIntracranial Pressure in Single-Suture Craniosynostosis
Cohen S, Persing J. Intracranial Pressure in Single-Suture Craniosynostosis. The Cleft Palate-Craniofacial Journal 1998, 35: 194-196. PMID: 9603551, DOI: 10.1597/1545-1569_1998_035_0194_ipissc_2.3.co_2.Peer-Reviewed Original Research
1993
Frontonasal dysplasia in two successive generations
Fryburg J, Persing J, Lin K. Frontonasal dysplasia in two successive generations. American Journal Of Medical Genetics 1993, 46: 712-714. PMID: 8362915, DOI: 10.1002/ajmg.1320460623.Peer-Reviewed Original ResearchMalignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases
Wanebo J, Malik J, Vandenberg S, Wanebo H, Driesen N, Persing J. Malignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases. Cancer 1993, 71: 1247-1253. PMID: 8435801, DOI: 10.1002/1097-0142(19930215)71:4<1247::aid-cncr2820710413>3.0.co;2-s.Peer-Reviewed Original ResearchConceptsMalignant peripheral nerve sheath tumorDisease-free survivalSurgical marginsTumor sizeTumor locationSurvival timeMedian disease-free survival timeBetter disease-free survivalMedian overall survival timePeripheral nerve sheath tumorsDisease-free survival timeVirginia Health Sciences CenterAdjuvant radiation therapyExtent of surgeryWide surgical marginsNerve sheath tumorsOverall survival timeQuality of marginsNeurofibromatosis type 1Type of treatmentHealth Sciences CenterAggressive surgeryClinicopathologic studyOverall survivalPatient age
1990
Craniofacial Trauma
Derdyn C, Persing J, Broaddus W, Delashaw J, Jane J, Levine P, Torner J. Craniofacial Trauma. Plastic & Reconstructive Surgery 1990, 86: 238-245. PMID: 2367573, DOI: 10.1097/00006534-199008000-00005.Peer-Reviewed Original ResearchConceptsFacial fracturesSurgical repairPoor prognosisLow Glasgow Coma ScoreMidline cerebral structuresEarly surgical repairGlasgow Coma ScoreTime of surgeryHead injury patientsSignificant poor prognosisFacial fracture repairCerebral traumaComa ScoreMultisystem traumaIntracranial hemorrhageRadiographic featuresIntracranial pressureRetrospective analysisCraniofacial traumaCerebral structuresPatientsFracture repairTraumaSignificant differencesPrognosisVascular Lesions Involving the Cranial Base
Shaffrey M, Persing J, Ferguson R, Shaffrey C, Cantrell R, Jane J, Newman S. Vascular Lesions Involving the Cranial Base. Journal Of Craniofacial Surgery 1990, 1: 106-111. PMID: 2094473, DOI: 10.1097/00001665-199001020-00007.Peer-Reviewed Original Research
1989
The Craniofacial Resection—Eleven‐Year Experience at the University of Virginia: Problems and Solutions
Levine P, Scher R, Jane J, Persing J, Newman S, Miller J, Cantrell R. The Craniofacial Resection—Eleven‐Year Experience at the University of Virginia: Problems and Solutions. Otolaryngology 1989, 101: 665-669. PMID: 2512555, DOI: 10.1177/019459988910100609.Peer-Reviewed Original ResearchConceptsVirginia Health Sciences CenterMedial canthal ligamentHealth Sciences CenterUnderwent repeatRecurrent diseaseExtended resectionNeurologic problemsSignificant complicationsCavernous sinusCraniofacial resectionSurgical techniqueLacrimal sacCanthal ligamentPatientsYears' experienceResectionComplicationsUniversity of VirginiaEsthesioneuroblastomaScience CenterSurgerySinusTumorsInfectionDisease
1987
Barrel Stave Osteotomy for Correction of Turribrachycephaly Craniosynostosis Deformity
Persing J, Edgerton M, Park T, Jane J. Barrel Stave Osteotomy for Correction of Turribrachycephaly Craniosynostosis Deformity. Annals Of Plastic Surgery 1987, 18: 488-493. PMID: 3605983, DOI: 10.1097/00000637-198706000-00004.Peer-Reviewed Original Research
1985
The Surgical Treatment of Fibrous Dysplasia
EDGERTON M, PERSING J, JANE J. The Surgical Treatment of Fibrous Dysplasia. Annals Of Surgery 1985, 202: 459-479. PMID: 3901941, PMCID: PMC1250946, DOI: 10.1097/00000658-198510000-00007.Peer-Reviewed Original ResearchConceptsFibrous dysplasiaLarge personal seriesEarly surgical managementGroup of patientsLoss of visionDonor site morbidityCranio-orbital reconstructionPostoperative absorptionDysplastic boneSurgical treatmentClinical featuresComplete resectionSinus infectionSurgical managementEndocrine abnormalitiesClinical findingsPersonal seriesSurgical approachBony lesionsMalignant changeEarly treatmentVisual functionBone graftingDifferential diagnosisImmediate reconstruction