2023
Long-term neurocognitive outcomes in 204 single-suture craniosynostosis patients
Junn A, Long A, Hauc S, Almeida M, Alper D, Rivera J, Mayes L, Persing J, Alperovich M. Long-term neurocognitive outcomes in 204 single-suture craniosynostosis patients. Child's Nervous System 2023, 39: 1921-1928. PMID: 36877207, DOI: 10.1007/s00381-023-05908-1.Peer-Reviewed Original ResearchConceptsFull Scale IQVisuomotor integrationVisual perceptionVerbal IQNeurocognitive testingVisual perception scoresHigher scoresLong-term neurocognitive outcomesCognitive profileWhite matter connectionsNeurocognitive deficitsIQPerception scoresMean IQNeurocognitive outcomesFrontal lobeLower scoresMotor controlMotor coordinationPerceptionNon-syndromic craniosynostosisUnicoronal synostosisScoresChildren 6
2022
Longitudinal Outpatient and School-Based Service Use among Children with Nonsyndromic Craniosynostosis
Peck CJ, Junn A, Park KE, Khetpal S, Cabrejo R, Singh A, Mayes L, Alperovich M, Persing J. Longitudinal Outpatient and School-Based Service Use among Children with Nonsyndromic Craniosynostosis. Plastic & Reconstructive Surgery 2022, 150: 1309-1317. PMID: 36126215, DOI: 10.1097/prs.0000000000009678.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildCraniosynostosesHumansMaleOutpatientsParentsSchool Health ServicesSchoolsConceptsLongitudinal needsNonsyndromic craniosynostosisParents of childrenService useSchool-based servicesAfrican American race/ethnicityTime of surgerySupportive servicesPercent of parentsPredictive variablesSignificant predictive variablesType of interventionRace/ethnicityNeurodevelopmental sequelaeMale sexMajority of parentsSchool-aged childrenUse of servicesPhysical therapyPresence of siblingsSignificant burdenOutpatientsHigh parental incomeMultifactorial natureSagittal synostosis
2019
Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis
Timberlake AT, Jin SC, Nelson-Williams C, Wu R, Furey CG, Islam B, Haider S, Loring E, Galm A, Steinbacher D, Larysz D, Staffenberg D, Flores R, Rodriguez E, Boggon T, Persing J, Lifton R, Lifton RP, Gunel M, Mane S, Bilguvar K, Gerstein M, Loring E, Nelson-Williams C, Lopez F, Knight J. Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 15116-15121. PMID: 31292255, PMCID: PMC6660739, DOI: 10.1073/pnas.1902041116.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlpha CateninChildChild, PreschoolCraniosynostosesExomeExome SequencingFemaleGene ExpressionGlypicansHistone AcetyltransferasesHumansMaleMutationNuclear ProteinsPedigreeRisk AssessmentSignal TransductionSkullSOXC Transcription FactorsTranscription Factor AP-2Zinc Finger Protein Gli2ConceptsRare damaging mutationsSyndromic craniosynostosisCongenital anomaliesDamaging mutationsSyndromic casesExome sequencingAdditional congenital anomaliesFrequent congenital anomaliesDamaging de novo mutationsNeural crest cell migrationDamaging de novoCrest cell migrationCS patientsMutation burdenChromatin modifiersSubsequent childrenTranscription factorsDe novo mutationsCS casesCS geneHedgehog pathwayDisease locusPremature fusionFunction mutationsCraniosynostosis
2014
The Impact of Age at Surgery on Long-Term Neuropsychological Outcomes in Sagittal Craniosynostosis
Patel A, Yang JF, Hashim PW, Travieso R, Terner J, Mayes LC, Kanev P, Duncan C, Jane J, Jane J, Pollack I, Losee JE, Bridgett DJ, Persing JA. The Impact of Age at Surgery on Long-Term Neuropsychological Outcomes in Sagittal Craniosynostosis. Plastic & Reconstructive Surgery 2014, 134: 608e-617e. PMID: 25357055, DOI: 10.1097/prs.0000000000000511.Peer-Reviewed Original ResearchConceptsLong-term neuropsychological outcomesWhole-vault cranioplastyNeuropsychological outcomesLong-term cognitive functioningHigher full-scale IQReading-related learning disabilitiesFull Scale IQWord readingCognitive functioningNeuropsychological measuresVerbal IQImproved long-term neurological outcomeNeuropsychological functionLearning DisabilitiesSagittal suture craniosynostosisIQNeurodevelopmental testsImpact of ageStrip craniectomyLong-term neurological outcomeNumerical operationsCLINICAL QUESTION/LEVELSuperior abilityTime of surgeryTechnique of surgery
2000
Long-Term Outcome of Embolotherapy and Surgery for High-Flow Extremity Arteriovenous Malformations
White R, Pollak J, Persing J, Henderson K, Thomson J, Burdge C. Long-Term Outcome of Embolotherapy and Surgery for High-Flow Extremity Arteriovenous Malformations. Journal Of Vascular And Interventional Radiology 2000, 11: 1285-1295. PMID: 11099238, DOI: 10.1016/s1051-0443(07)61302-5.Peer-Reviewed Original ResearchConceptsHigh-flow arteriovenous malformationsSuccessful embolotherapyArteriovenous malformationsExcellent long-term palliationExtremity arteriovenous malformationLong-term palliationRecurrence of symptomsLong-term efficacyMaximum painSurgical resectionSymptomatic improvementAffected handConsecutive patientsNerve blockSurgical cutdownDiffuse involvementTerm outcomesBony erosionFemoral arteryUpper extremitySkin graftsPatientsEmbolotherapy proceduresEmbolotherapyPain
1993
Frontonasal dysplasia in two successive generations
Fryburg J, Persing J, Lin K. Frontonasal dysplasia in two successive generations. American Journal Of Medical Genetics 1993, 46: 712-714. PMID: 8362915, DOI: 10.1002/ajmg.1320460623.Peer-Reviewed Original ResearchMalignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases
Wanebo J, Malik J, Vandenberg S, Wanebo H, Driesen N, Persing J. Malignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases. Cancer 1993, 71: 1247-1253. PMID: 8435801, DOI: 10.1002/1097-0142(19930215)71:4<1247::aid-cncr2820710413>3.0.co;2-s.Peer-Reviewed Original ResearchConceptsMalignant peripheral nerve sheath tumorDisease-free survivalSurgical marginsTumor sizeTumor locationSurvival timeMedian disease-free survival timeBetter disease-free survivalMedian overall survival timePeripheral nerve sheath tumorsDisease-free survival timeVirginia Health Sciences CenterAdjuvant radiation therapyExtent of surgeryWide surgical marginsNerve sheath tumorsOverall survival timeQuality of marginsNeurofibromatosis type 1Type of treatmentHealth Sciences CenterAggressive surgeryClinicopathologic studyOverall survivalPatient age
1992
The Serratus Anterior Free Tissue Transfer for Craniofacial Reconstruction
Angel M, Bridges R, Levine P, Cantrell R, Persing J. The Serratus Anterior Free Tissue Transfer for Craniofacial Reconstruction. Journal Of Craniofacial Surgery 1992, 3: 207-212. PMID: 1298423, DOI: 10.1097/00001665-199212000-00006.Peer-Reviewed Original Research
1991
Electrophysiological findings in localized hypertrophic mononeuropathy
Phillips L, Persing J, Vandenberg S. Electrophysiological findings in localized hypertrophic mononeuropathy. Muscle & Nerve 1991, 14: 335-341. PMID: 1851247, DOI: 10.1002/mus.880140408.Peer-Reviewed Original ResearchConceptsHypertrophic mononeuropathyIntraoperative recordingEvolution of abnormalitiesPerineurial cell proliferationProximal ulnar nerveNerve action potentialsUlnar nerveSurgical managementAxonal degenerationElectrophysiological findingsImmunohistochemical studyElectrophysiological observationsUndefined stimuliAction potentialsMyelin sheathCell proliferationProgressive thinningMononeuropathyElectrophysiological responsesNerveLesionsNeuropathyResectionRecordingsLater stages
1990
Craniofacial Trauma
Derdyn C, Persing J, Broaddus W, Delashaw J, Jane J, Levine P, Torner J. Craniofacial Trauma. Plastic & Reconstructive Surgery 1990, 86: 238-245. PMID: 2367573, DOI: 10.1097/00006534-199008000-00005.Peer-Reviewed Original ResearchConceptsFacial fracturesSurgical repairPoor prognosisLow Glasgow Coma ScoreMidline cerebral structuresEarly surgical repairGlasgow Coma ScoreTime of surgeryHead injury patientsSignificant poor prognosisFacial fracture repairCerebral traumaComa ScoreMultisystem traumaIntracranial hemorrhageRadiographic featuresIntracranial pressureRetrospective analysisCraniofacial traumaCerebral structuresPatientsFracture repairTraumaSignificant differencesPrognosis
1989
The Craniofacial Resection—Eleven‐Year Experience at the University of Virginia: Problems and Solutions
Levine P, Scher R, Jane J, Persing J, Newman S, Miller J, Cantrell R. The Craniofacial Resection—Eleven‐Year Experience at the University of Virginia: Problems and Solutions. Otolaryngology 1989, 101: 665-669. PMID: 2512555, DOI: 10.1177/019459988910100609.Peer-Reviewed Original ResearchConceptsVirginia Health Sciences CenterMedial canthal ligamentHealth Sciences CenterUnderwent repeatRecurrent diseaseExtended resectionNeurologic problemsSignificant complicationsCavernous sinusCraniofacial resectionSurgical techniqueLacrimal sacCanthal ligamentPatientsYears' experienceResectionComplicationsUniversity of VirginiaEsthesioneuroblastomaScience CenterSurgerySinusTumorsInfectionDisease
1985
The Surgical Treatment of Fibrous Dysplasia
EDGERTON M, PERSING J, JANE J. The Surgical Treatment of Fibrous Dysplasia. Annals Of Surgery 1985, 202: 459-479. PMID: 3901941, PMCID: PMC1250946, DOI: 10.1097/00000658-198510000-00007.Peer-Reviewed Original ResearchConceptsFibrous dysplasiaLarge personal seriesEarly surgical managementGroup of patientsLoss of visionDonor site morbidityCranio-orbital reconstructionPostoperative absorptionDysplastic boneSurgical treatmentClinical featuresComplete resectionSinus infectionSurgical managementEndocrine abnormalitiesClinical findingsPersonal seriesSurgical approachBony lesionsMalignant changeEarly treatmentVisual functionBone graftingDifferential diagnosisImmediate reconstruction