2017
De novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis
Timberlake AT, Furey CG, Choi J, Nelson-Williams C, Loring E, Galm A, Kahle K, Steinbacher D, Larysz D, Persing J, Lifton R, Bilguvar K, Mane S, Tikhonova I, Castaldi C, Knight J. De novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e7341-e7347. PMID: 28808027, PMCID: PMC5584457, DOI: 10.1073/pnas.1709255114.Peer-Reviewed Original ResearchConceptsBone morphogenetic proteinRas/ERKDe novo mutationsNovo mutationsRas/ERK pathwayDamaging de novo mutationsHigh locus heterogeneityRare syndromic diseaseCommon risk variantsInhibitor of WntSyndromic craniosynostosesNew genesParent-offspring triosSyndromic diseaseMorphogenetic proteinsNegative regulatorERK pathwayMore cranial suturesGenesMidline craniosynostosisRisk variantsWntLocus heterogeneityMutationsExome sequencing
2010
Complication Rates of Lipoabdominoplasty versus Traditional Abdominoplasty in High-Risk Patients
Samra S, Sawh-Martinez R, Barry O, Persing JA. Complication Rates of Lipoabdominoplasty versus Traditional Abdominoplasty in High-Risk Patients. Plastic & Reconstructive Surgery 2010, 125: 683-690. PMID: 20124853, DOI: 10.1097/prs.0b013e3181c82fb0.Peer-Reviewed Original ResearchConceptsHigh-risk patientsPerfusion-related complicationsComplication rateTraditional abdominoplastyPercent of patientsPrevious abdominal surgeryAbdominal scarringActive smokingChart reviewSmoking historyAbdominal surgeryActive smokersSkin necrosisSurgical revisionWound infectionAbdominal scarRevision surgeryAbdominoplasty flapCosmetic clinicsPatientsComplicationsAbdominoplastyLipoabdominoplastySignificant differencesSurgery
2000
Long-Term Outcome of Embolotherapy and Surgery for High-Flow Extremity Arteriovenous Malformations
White R, Pollak J, Persing J, Henderson K, Thomson J, Burdge C. Long-Term Outcome of Embolotherapy and Surgery for High-Flow Extremity Arteriovenous Malformations. Journal Of Vascular And Interventional Radiology 2000, 11: 1285-1295. PMID: 11099238, DOI: 10.1016/s1051-0443(07)61302-5.Peer-Reviewed Original ResearchConceptsHigh-flow arteriovenous malformationsSuccessful embolotherapyArteriovenous malformationsExcellent long-term palliationExtremity arteriovenous malformationLong-term palliationRecurrence of symptomsLong-term efficacyMaximum painSurgical resectionSymptomatic improvementAffected handConsecutive patientsNerve blockSurgical cutdownDiffuse involvementTerm outcomesBony erosionFemoral arteryUpper extremitySkin graftsPatientsEmbolotherapy proceduresEmbolotherapyPain
1998
Modified Le Fort III Osteotomy in Adult Crouzon Disease
Narayan D, Persing J. Modified Le Fort III Osteotomy in Adult Crouzon Disease. Journal Of Craniofacial Surgery 1998, 9: 481-485. PMID: 9780921, DOI: 10.1097/00001665-199809000-00020.Peer-Reviewed Original Research
1996
Frequent clones of p53-mutated keratinocytes in normal human skin
Jonason A, Kunala S, Price G, Restifo R, Spinelli H, Persing J, Leffell D, Tarone R, Brash D. Frequent clones of p53-mutated keratinocytes in normal human skin. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 14025-14029. PMID: 8943054, PMCID: PMC19488, DOI: 10.1073/pnas.93.24.14025.Peer-Reviewed Original ResearchConceptsP53-mutated keratinocytesNormal individualsSun-shielded skinSun-exposed skinNormal human skinHuman skinWhole-mount preparationsP53-mutated cellsCancer predictsDermal-epidermal junctionSubstantial burdenFrequent clonesClonal expansionHair folliclesGenetic hitsTumor promoterSkinKeratinocytesCells
1995
Reconstruction of the Cranial Base
Spinelli H, Persing J, Walser B. Reconstruction of the Cranial Base. Clinics In Plastic Surgery 1995, 22: 555-561. PMID: 7554723, DOI: 10.1016/s0094-1298(20)30997-4.Peer-Reviewed Original Research
1993
Frontonasal dysplasia in two successive generations
Fryburg J, Persing J, Lin K. Frontonasal dysplasia in two successive generations. American Journal Of Medical Genetics 1993, 46: 712-714. PMID: 8362915, DOI: 10.1002/ajmg.1320460623.Peer-Reviewed Original ResearchMalignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases
Wanebo J, Malik J, Vandenberg S, Wanebo H, Driesen N, Persing J. Malignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases. Cancer 1993, 71: 1247-1253. PMID: 8435801, DOI: 10.1002/1097-0142(19930215)71:4<1247::aid-cncr2820710413>3.0.co;2-s.Peer-Reviewed Original ResearchConceptsMalignant peripheral nerve sheath tumorDisease-free survivalSurgical marginsTumor sizeTumor locationSurvival timeMedian disease-free survival timeBetter disease-free survivalMedian overall survival timePeripheral nerve sheath tumorsDisease-free survival timeVirginia Health Sciences CenterAdjuvant radiation therapyExtent of surgeryWide surgical marginsNerve sheath tumorsOverall survival timeQuality of marginsNeurofibromatosis type 1Type of treatmentHealth Sciences CenterAggressive surgeryClinicopathologic studyOverall survivalPatient age
1992
The Serratus Anterior Free Tissue Transfer for Craniofacial Reconstruction
Angel M, Bridges R, Levine P, Cantrell R, Persing J. The Serratus Anterior Free Tissue Transfer for Craniofacial Reconstruction. Journal Of Craniofacial Surgery 1992, 3: 207-212. PMID: 1298423, DOI: 10.1097/00001665-199212000-00006.Peer-Reviewed Original Research
1990
Craniofacial Trauma
Derdyn C, Persing J, Broaddus W, Delashaw J, Jane J, Levine P, Torner J. Craniofacial Trauma. Plastic & Reconstructive Surgery 1990, 86: 238-245. PMID: 2367573, DOI: 10.1097/00006534-199008000-00005.Peer-Reviewed Original ResearchConceptsFacial fracturesSurgical repairPoor prognosisLow Glasgow Coma ScoreMidline cerebral structuresEarly surgical repairGlasgow Coma ScoreTime of surgeryHead injury patientsSignificant poor prognosisFacial fracture repairCerebral traumaComa ScoreMultisystem traumaIntracranial hemorrhageRadiographic featuresIntracranial pressureRetrospective analysisCraniofacial traumaCerebral structuresPatientsFracture repairTraumaSignificant differencesPrognosis
1989
The Craniofacial Resection—Eleven‐Year Experience at the University of Virginia: Problems and Solutions
Levine P, Scher R, Jane J, Persing J, Newman S, Miller J, Cantrell R. The Craniofacial Resection—Eleven‐Year Experience at the University of Virginia: Problems and Solutions. Otolaryngology 1989, 101: 665-669. PMID: 2512555, DOI: 10.1177/019459988910100609.Peer-Reviewed Original ResearchConceptsVirginia Health Sciences CenterMedial canthal ligamentHealth Sciences CenterUnderwent repeatRecurrent diseaseExtended resectionNeurologic problemsSignificant complicationsCavernous sinusCraniofacial resectionSurgical techniqueLacrimal sacCanthal ligamentPatientsYears' experienceResectionComplicationsUniversity of VirginiaEsthesioneuroblastomaScience CenterSurgerySinusTumorsInfectionDiseaseMultiple sclerosis and brain tumor: A diagnostic challenge
Paley R, Persing J, Doctor A, Westwater J, Roberson J, Edlich R. Multiple sclerosis and brain tumor: A diagnostic challenge. Journal Of Emergency Medicine 1989, 7: 241-244. PMID: 2545771, DOI: 10.1016/0736-4679(89)90353-3.Peer-Reviewed Original Research
1988
Tarsal Tunnel Syndrome Caused by Sciatic Nerve Schwannoma
Persing J, Nachbar J, Vollmer D. Tarsal Tunnel Syndrome Caused by Sciatic Nerve Schwannoma. Annals Of Plastic Surgery 1988, 20: 252-255. PMID: 3358617, DOI: 10.1097/00000637-198803000-00012.Peer-Reviewed Original Research
1987
Late surgical treatment of unilateral coronal synostosis using methyl methacrylate.
Persing J, Cronin A, Delashaw J, Edgerton M, Henson S, Jane J. Late surgical treatment of unilateral coronal synostosis using methyl methacrylate. Journal Of Neurosurgery 1987, 66: 793-9. PMID: 3553459, DOI: 10.3171/jns.1987.66.6.0793.Peer-Reviewed Original Research
1984
Galeal-pericranial flaps in head and neck reconstruction anatomy and application
Horowitz J, Persing J, Nichter L, Morgan R, Edgerton M. Galeal-pericranial flaps in head and neck reconstruction anatomy and application. The American Journal Of Surgery 1984, 148: 489-497. PMID: 6486318, DOI: 10.1016/0002-9610(84)90375-1.Peer-Reviewed Original ResearchConceptsPericranial flapNew anatomic findingsRich vascular plexusMinimal donor site morbidityInternal carotid arteryDonor site morbidityTemporalis muscle fasciaNeoplastic causesMucosal graftDual supplyGaleal-pericranial flapNeck surgeryReconstructive patientsAnatomic findingsCarotid arteryNeck deformityTemporalis fasciaBlood flowMuscle fasciaFascial layersSite morbidityRecipient siteVascular plexusLayerFascia