2022
De novo mutations in the BMP signaling pathway in lambdoid craniosynostosis
Timberlake AT, Kiziltug E, Jin SC, Nelson-Williams C, Loring E, Allocco A, Marlier A, Banka S, Stuart H, Passos-Buenos M, Rosa R, Rogatto S, Tonne E, Stiegler A, Boggon T, Alperovich M, Steinbacher D, Staffenberg D, Flores R, Persing J, Kahle K, Lifton R. De novo mutations in the BMP signaling pathway in lambdoid craniosynostosis. Human Genetics 2022, 142: 21-32. PMID: 35997807, DOI: 10.1007/s00439-022-02477-2.Peer-Reviewed Original ResearchConceptsDe novo mutationsDamaging de novo mutationsSingle-cell RNA sequencing analysisTranscriptional co-repressorTarget sequence recognitionRNA sequencing analysisTranscription factor NfixNovo mutationsEnrichment of mutationsBMP receptorsCo-repressorParent-offspring triosTranscription factorsGenetic gainImplicating perturbationsOsteoblast precursorsPremature suture fusionSequencing analysisMolecular etiologySequence recognitionMissense mutationsMutationsExome sequencingGenetic etiologyOsteoprogenitor cells
2017
De novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis
Timberlake AT, Furey CG, Choi J, Nelson-Williams C, Loring E, Galm A, Kahle K, Steinbacher D, Larysz D, Persing J, Lifton R, Bilguvar K, Mane S, Tikhonova I, Castaldi C, Knight J. De novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e7341-e7347. PMID: 28808027, PMCID: PMC5584457, DOI: 10.1073/pnas.1709255114.Peer-Reviewed Original ResearchConceptsBone morphogenetic proteinRas/ERKDe novo mutationsNovo mutationsRas/ERK pathwayDamaging de novo mutationsHigh locus heterogeneityRare syndromic diseaseCommon risk variantsInhibitor of WntSyndromic craniosynostosesNew genesParent-offspring triosSyndromic diseaseMorphogenetic proteinsNegative regulatorERK pathwayMore cranial suturesGenesMidline craniosynostosisRisk variantsWntLocus heterogeneityMutationsExome sequencing
1998
Commentary on Effect of Cranial Suture Autotransplantation From Metopic to Coronal Suture
Persing J. Commentary on Effect of Cranial Suture Autotransplantation From Metopic to Coronal Suture. Journal Of Craniofacial Surgery 1998, 9: 440. PMID: 9780912, DOI: 10.1097/00001665-199809000-00007.Peer-Reviewed Original Research
1995
A Rapid in Vitro Assay of Cellular Chemomigration in an Epithelial Carcinoma Cell Line
Ricciardelli E, Persing J, Romano J, Morgan R, Ogle R. A Rapid in Vitro Assay of Cellular Chemomigration in an Epithelial Carcinoma Cell Line. Plastic & Reconstructive Surgery 1995, 96: 1689-1693. PMID: 7480290, DOI: 10.1097/00006534-199512000-00024.Peer-Reviewed Original ResearchRepair of critical size rat calvarial defects using extracellular matrix protein gels.
Sweeney T, Opperman L, Persing J, Ogle R. Repair of critical size rat calvarial defects using extracellular matrix protein gels. Journal Of Neurosurgery 1995, 83: 710-5. PMID: 7545744, DOI: 10.3171/jns.1995.83.4.0710.Peer-Reviewed Original Research
1994
In the Absence of Periosteum, Transplanted Fetal and Neonatal Rat Coronal Sutures Resist Osseous Obliteration
Opperman L, Persing J, Sheen R, Ogle R. In the Absence of Periosteum, Transplanted Fetal and Neonatal Rat Coronal Sutures Resist Osseous Obliteration. Journal Of Craniofacial Surgery 1994, 5: 327-332. PMID: 7833415, DOI: 10.1097/00001665-199411000-00012.Peer-Reviewed Original Research
1993
Tissue interactions with underlying dura mater inhibit osseous obliteration of developing cranial sutures
Opperman L, Sweeney T, Redmon J, Persing J, Ogle R. Tissue interactions with underlying dura mater inhibit osseous obliteration of developing cranial sutures. Developmental Dynamics 1993, 198: 312-322. PMID: 8130378, DOI: 10.1002/aja.1001980408.Peer-Reviewed Original ResearchConceptsDura materCranial baseRat transplant modelParietal boneCranial suturesTransplant modelTransplanted tissueDay 19Fetal dura materBone growthOsseous obliterationWeeksSutureMaterPatencyBiochemical factorsBiomechanical forcesBiomechanical influenceCoronal sutureBoneTissue interactionsSuture patencyOssificationInitial morphogenesisSkull growth
1991
Craniofacial Suture Stenosis
Persing J, Lettieri J, Cronin A, Wolcott W, Singh V, Morgan E. Craniofacial Suture Stenosis. Plastic & Reconstructive Surgery 1991, 88: 563-571. PMID: 1896528, DOI: 10.1097/00006534-199110000-00001.Peer-Reviewed Original ResearchSkull Base Expansion
Persing J, Morgan E, Cronin A, Wolcott W. Skull Base Expansion. Plastic & Reconstructive Surgery 1991, 87: 1028-1033. PMID: 2034723, DOI: 10.1097/00006534-199106000-00003.Peer-Reviewed Original Research
1987
Restricted growth at the frontonasal suture: Alterations in craniofacial growth in rabbits
Babler W, Persing J, Nagorsky M, Jane J. Restricted growth at the frontonasal suture: Alterations in craniofacial growth in rabbits. Developmental Dynamics 1987, 178: 90-98. PMID: 3825967, DOI: 10.1002/aja.1001780112.Peer-Reviewed Original ResearchConceptsDays of ageNewborn New Zealand White rabbitsAnterior lambdoid suturesNew Zealand white rabbitsNasal bone lengthSham-treated groupZealand white rabbitsCranial suturesBilateral implantationBirth weightBilateral applicationWhite rabbitsExperimental animalsApposition of boneNasal boneMorphometric changesPremature closureInternasal sutureAnterior portionYoung rabbitsSignificant decreaseFrontonasal sutureSignificant shorteningSutureBone length
1986
Skull Expansion in Experimental Craniosynostosis
Persing J, Babler W, Nagorsky M, Edgerton M, Jane J, sing J. Skull Expansion in Experimental Craniosynostosis. Plastic & Reconstructive Surgery 1986, 78: 594-603. PMID: 3763746, DOI: 10.1097/00006534-198611000-00006.Peer-Reviewed Original ResearchExperimental Unilateral Coronal Synostosis in Rabbits
Persing J, Babler W, Jane J, Duckworth P. Experimental Unilateral Coronal Synostosis in Rabbits. Plastic & Reconstructive Surgery 1986, 77: 369-376. PMID: 3952194, DOI: 10.1097/00006534-198603000-00003.Peer-Reviewed Original Research
1982
Compensatory growth following premature closure of the coronal suture in rabbits.
Babler W, Persing J, Winn H, Jane J, Rodeheaver G. Compensatory growth following premature closure of the coronal suture in rabbits. Journal Of Neurosurgery 1982, 57: 535-42. PMID: 7108603, DOI: 10.3171/jns.1982.57.4.0535.Peer-Reviewed Original ResearchConceptsEarly surgical releasePremature closureSurgical releaseSuture resultsCoronal sutureAnterior lambdoid suturesNew Zealand white rabbitsZealand white rabbitsDays of ageTransverse sutureWhite rabbitsMorphometric changesCompensatory growthAffected sutureSutureFused suturesLambdoid sutureCranial suturesSkull growth after coronal suturectomy, periostectomy, and dural transection.
Babler W, Persing J, Persson K, Winn H, Jane J, Rodeheaver G. Skull growth after coronal suturectomy, periostectomy, and dural transection. Journal Of Neurosurgery 1982, 56: 529-35. PMID: 7062124, DOI: 10.3171/jns.1982.56.4.0529.Peer-Reviewed Original ResearchExperimental alteration of cranial suture growth: effects on the neurocranium, basicranium, and midface.
Babler W, Persing J. Experimental alteration of cranial suture growth: effects on the neurocranium, basicranium, and midface. Progress In Clinical And Biological Research 1982, 101: 333-45. PMID: 7156144.Peer-Reviewed Original Research
1981
Age as a critical factor in the success of surgical correction of craniosynostosis.
Persing J, Babler W, Winn H, Jane J, Rodeheaver G. Age as a critical factor in the success of surgical correction of craniosynostosis. Journal Of Neurosurgery 1981, 54: 601-6. PMID: 7014791, DOI: 10.3171/jns.1981.54.5.0601.Peer-Reviewed Original Research
1979
Craniofacial growth following experimental craniosynostosis and craniectomy in rabbits.
Persson K, Roy W, Persing J, Rodeheaver G, Winn H. Craniofacial growth following experimental craniosynostosis and craniectomy in rabbits. Journal Of Neurosurgery 1979, 50: 187-97. PMID: 430131, DOI: 10.3171/jns.1979.50.2.0187.Peer-Reviewed Original Research