2023
Tranexamic Acid in Facial Feminization Surgery: Quantifying a High-risk Setting With Exogenous Estrogen Supplementation
Alper D, Almeida M, Rivera J, Hosseini H, Williams M, Long A, Prassinos A, Mookerjee V, Persing J, Alperovich M. Tranexamic Acid in Facial Feminization Surgery: Quantifying a High-risk Setting With Exogenous Estrogen Supplementation. Journal Of Craniofacial Surgery 2023, 34: 1452-1455. PMID: 37277900, DOI: 10.1097/scs.0000000000009415.Peer-Reviewed Original ResearchConceptsVenous thromboembolic eventsSafety of TXAExogenous estrogen supplementationTranexamic acidEstrogen supplementationFacial feminization surgeryCaprini scoreVTE ratesBlood lossOperative timeFeminization surgeryHigh-risk patient populationIntraoperative tranexamic acidRisk patient populationHigh-risk settingsUnpaired t-testEstrogen therapyThromboembolic eventsRetrospective reviewHematoma rateProthrombotic agentsPatient populationProcedure typeMedical CenterElevated riskQuality and Readability of Accessible Facial Feminization Literature
Alper D, Almeida M, De Baun H, Glahn J, Rivera J, Williams M, Collar J, Mookerjee V, Persing J, Alperovich M. Quality and Readability of Accessible Facial Feminization Literature. Annals Of Plastic Surgery 2023, 90: 533-537. PMID: 37311308, DOI: 10.1097/sap.0000000000003569.Peer-Reviewed Original ResearchLong-term neurocognitive outcomes in 204 single-suture craniosynostosis patients
Junn A, Long A, Hauc S, Almeida M, Alper D, Rivera J, Mayes L, Persing J, Alperovich M. Long-term neurocognitive outcomes in 204 single-suture craniosynostosis patients. Child's Nervous System 2023, 39: 1921-1928. PMID: 36877207, DOI: 10.1007/s00381-023-05908-1.Peer-Reviewed Original ResearchConceptsFull Scale IQVisuomotor integrationVisual perceptionVerbal IQNeurocognitive testingVisual perception scoresHigher scoresLong-term neurocognitive outcomesCognitive profileWhite matter connectionsNeurocognitive deficitsIQPerception scoresMean IQNeurocognitive outcomesFrontal lobeLower scoresMotor controlMotor coordinationPerceptionNon-syndromic craniosynostosisUnicoronal synostosisScoresChildren 6
2022
Utilizing Computer-Assisted Design and Virtual Surgical Planning for Correction of Unilateral Lambdoid Synostosis
Long A, Gudbranson E, Almeida M, Chong L, Mozaffari M, Alper D, Rivera J, Persing J, Alperovich M. Utilizing Computer-Assisted Design and Virtual Surgical Planning for Correction of Unilateral Lambdoid Synostosis. Journal Of Craniofacial Surgery 2022, 34: 1036-1038. PMID: 36730112, DOI: 10.1097/scs.0000000000009141.Peer-Reviewed Original ResearchConceptsUnilateral lambdoid synostosisLambdoid synostosisSurgical planningCranial vault reconstructionCranial vault remodelingVirtual surgical planningSingle-suture craniosynostosisOperative timePatient presentingSurgical approachTomography scanRare formVault remodelingSynostosisPresentingSurgical modelingAssessment of Sex Diversity Among Craniofacial Academic Faculty
Rivera J, Hauc S, Juan H, Williams M, Stögner V, Najafali D, Long A, Almeida M, Persing J, Alperovich M. Assessment of Sex Diversity Among Craniofacial Academic Faculty. Journal Of Craniofacial Surgery 2022, 34: 202-205. PMID: 36608098, DOI: 10.1097/scs.0000000000009109.Peer-Reviewed Original ResearchConceptsAmerican Cleft Palate-Craniofacial AssociationMaxillofacial surgeonsSignificant differencesAmerican SocietyCleft Palate-Craniofacial JournalFellowship programsSex disparitiesMultiple specialtiesSex diversityPlastic surgeryCraniofacial surgeryMedical specialtiesSurgery facultyYears of experienceSurgerySurgical residencySurgery journalsLongitudinal Outpatient and School-Based Service Use among Children with Nonsyndromic Craniosynostosis
Peck CJ, Junn A, Park KE, Khetpal S, Cabrejo R, Singh A, Mayes L, Alperovich M, Persing J. Longitudinal Outpatient and School-Based Service Use among Children with Nonsyndromic Craniosynostosis. Plastic & Reconstructive Surgery 2022, 150: 1309-1317. PMID: 36126215, DOI: 10.1097/prs.0000000000009678.Peer-Reviewed Original ResearchConceptsLongitudinal needsNonsyndromic craniosynostosisParents of childrenService useSchool-based servicesAfrican American race/ethnicityTime of surgerySupportive servicesPercent of parentsPredictive variablesSignificant predictive variablesType of interventionRace/ethnicityNeurodevelopmental sequelaeMale sexMajority of parentsSchool-aged childrenUse of servicesPhysical therapyPresence of siblingsSignificant burdenOutpatientsHigh parental incomeMultifactorial natureSagittal synostosis
2021
Relative Importance of Facial Thirds in Facial Feminization Surgery
Ching A, Persing J. Relative Importance of Facial Thirds in Facial Feminization Surgery. Aesthetic Surgery Journal 2021, 41: np1251-np1252. PMID: 33668067, DOI: 10.1093/asj/sjab108.Peer-Reviewed Original Research
2019
Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis
Timberlake AT, Jin SC, Nelson-Williams C, Wu R, Furey CG, Islam B, Haider S, Loring E, Galm A, Steinbacher D, Larysz D, Staffenberg D, Flores R, Rodriguez E, Boggon T, Persing J, Lifton R, Lifton RP, Gunel M, Mane S, Bilguvar K, Gerstein M, Loring E, Nelson-Williams C, Lopez F, Knight J. Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 15116-15121. PMID: 31292255, PMCID: PMC6660739, DOI: 10.1073/pnas.1902041116.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlpha CateninChildChild, PreschoolCraniosynostosesExomeExome SequencingFemaleGene ExpressionGlypicansHistone AcetyltransferasesHumansMaleMutationNuclear ProteinsPedigreeRisk AssessmentSignal TransductionSkullSOXC Transcription FactorsTranscription Factor AP-2Zinc Finger Protein Gli2ConceptsRare damaging mutationsSyndromic craniosynostosisCongenital anomaliesDamaging mutationsSyndromic casesExome sequencingAdditional congenital anomaliesFrequent congenital anomaliesDamaging de novo mutationsNeural crest cell migrationDamaging de novoCrest cell migrationCS patientsMutation burdenChromatin modifiersSubsequent childrenTranscription factorsDe novo mutationsCS casesCS geneHedgehog pathwayDisease locusPremature fusionFunction mutationsCraniosynostosis
2017
De novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis
Timberlake AT, Furey CG, Choi J, Nelson-Williams C, Loring E, Galm A, Kahle K, Steinbacher D, Larysz D, Persing J, Lifton R, Bilguvar K, Mane S, Tikhonova I, Castaldi C, Knight J. De novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e7341-e7347. PMID: 28808027, PMCID: PMC5584457, DOI: 10.1073/pnas.1709255114.Peer-Reviewed Original ResearchConceptsBone morphogenetic proteinRas/ERKDe novo mutationsNovo mutationsRas/ERK pathwayDamaging de novo mutationsHigh locus heterogeneityRare syndromic diseaseCommon risk variantsInhibitor of WntSyndromic craniosynostosesNew genesParent-offspring triosSyndromic diseaseMorphogenetic proteinsNegative regulatorERK pathwayMore cranial suturesGenesMidline craniosynostosisRisk variantsWntLocus heterogeneityMutationsExome sequencing
2012
Improved Correction of Supraorbital Rim Deformity in Craniosynostosis by the “Tilt” Procedure
Patel A, Chang CC, Terner JS, Tuggle CT, Persing JA. Improved Correction of Supraorbital Rim Deformity in Craniosynostosis by the “Tilt” Procedure. Journal Of Craniofacial Surgery 2012, 23: 370-373. PMID: 22421828, DOI: 10.1097/scs.0b013e318240fac8.Peer-Reviewed Original Research
2011
Combined metopic and sagittal craniosynostosis: is it worse than sagittal synostosis alone?
Terner JS, Travieso R, Lee SS, Forte AJ, Patel A, Persing JA. Combined metopic and sagittal craniosynostosis: is it worse than sagittal synostosis alone? Neurosurgical FOCUS 2011, 31: e2. PMID: 21806341, DOI: 10.3171/2011.6.focus11100.Peer-Reviewed Original ResearchConceptsMonths of ageSmaller intracranial volumeBrain dysfunctionIntracranial volumeSagittal synostosisPatient groupVentricular volumeAge groupsSagittal craniosynostosisCSF spaceBrain volume reductionBrain tissue volumesSex-matched controlsSame age groupVolume reductionRetrospective chartFemale patientsForms of craniosynostosisSagittal synostosesPatientsYoung infantsBrain tissueCT reviewIntracranial compartmentDysfunction
2010
Plastic Surgery during Natural Disasters: Lessons from Haiti
Patel A, Mcrae M, Mcrae M, Sinha I, Persing J. Plastic Surgery during Natural Disasters: Lessons from Haiti. Plastic & Reconstructive Surgery 2010, 126: 111e. PMID: 20679815, DOI: 10.1097/prs.0b013e3181df7255.Peer-Reviewed Original ResearchIntracranial Compartment Volume Changes in Sagittal Craniosynostosis Patients: Influence of Comprehensive Cranioplasty
Lee SS, Duncan CC, Knoll BI, Persing JA. Intracranial Compartment Volume Changes in Sagittal Craniosynostosis Patients: Influence of Comprehensive Cranioplasty. Plastic & Reconstructive Surgery 2010, 126: 187-196. PMID: 20595867, DOI: 10.1097/prs.0b013e3181dab5be.Peer-Reviewed Original ResearchConceptsIntracranial compartment volumesSagittal synostosis patientsBrain tissue volumesGender-matched controlsBrain volumeCompartment volumeAge groupsSagittal craniosynostosis patientsTissue volumeMonths of ageConsecutive childrenCorrective surgeryTomographic scanRetrospective analysisPatientsTherapeutic objectivesCraniosynostosis patientsSagittal synostosisSagittal craniosynostosisPatient dataVolume enlargementAgeCranioplastyMonthsEquivalent increase
2000
Long-Term Outcome of Embolotherapy and Surgery for High-Flow Extremity Arteriovenous Malformations
White R, Pollak J, Persing J, Henderson K, Thomson J, Burdge C. Long-Term Outcome of Embolotherapy and Surgery for High-Flow Extremity Arteriovenous Malformations. Journal Of Vascular And Interventional Radiology 2000, 11: 1285-1295. PMID: 11099238, DOI: 10.1016/s1051-0443(07)61302-5.Peer-Reviewed Original ResearchConceptsHigh-flow arteriovenous malformationsSuccessful embolotherapyArteriovenous malformationsExcellent long-term palliationExtremity arteriovenous malformationLong-term palliationRecurrence of symptomsLong-term efficacyMaximum painSurgical resectionSymptomatic improvementAffected handConsecutive patientsNerve blockSurgical cutdownDiffuse involvementTerm outcomesBony erosionFemoral arteryUpper extremitySkin graftsPatientsEmbolotherapy proceduresEmbolotherapyPain
1997
Management of the Ventricular Shunt in Posterior Deformities of the Skull in Craniosynostosis
Sun P, Shin J, Persing J. Management of the Ventricular Shunt in Posterior Deformities of the Skull in Craniosynostosis. Journal Of Craniofacial Surgery 1997, 8: 38-41. PMID: 10332297, DOI: 10.1097/00001665-199701000-00013.Peer-Reviewed Original Research
1995
Repair of critical size rat calvarial defects using extracellular matrix protein gels.
Sweeney T, Opperman L, Persing J, Ogle R. Repair of critical size rat calvarial defects using extracellular matrix protein gels. Journal Of Neurosurgery 1995, 83: 710-5. PMID: 7545744, DOI: 10.3171/jns.1995.83.4.0710.Peer-Reviewed Original Research
1994
In the Absence of Periosteum, Transplanted Fetal and Neonatal Rat Coronal Sutures Resist Osseous Obliteration
Opperman L, Persing J, Sheen R, Ogle R. In the Absence of Periosteum, Transplanted Fetal and Neonatal Rat Coronal Sutures Resist Osseous Obliteration. Journal Of Craniofacial Surgery 1994, 5: 327-332. PMID: 7833415, DOI: 10.1097/00001665-199411000-00012.Peer-Reviewed Original Research
1993
Tissue interactions with underlying dura mater inhibit osseous obliteration of developing cranial sutures
Opperman L, Sweeney T, Redmon J, Persing J, Ogle R. Tissue interactions with underlying dura mater inhibit osseous obliteration of developing cranial sutures. Developmental Dynamics 1993, 198: 312-322. PMID: 8130378, DOI: 10.1002/aja.1001980408.Peer-Reviewed Original ResearchConceptsDura materCranial baseRat transplant modelParietal boneCranial suturesTransplant modelTransplanted tissueDay 19Fetal dura materBone growthOsseous obliterationWeeksSutureMaterPatencyBiochemical factorsBiomechanical forcesBiomechanical influenceCoronal sutureBoneTissue interactionsSuture patencyOssificationInitial morphogenesisSkull growthFrontonasal dysplasia in two successive generations
Fryburg J, Persing J, Lin K. Frontonasal dysplasia in two successive generations. American Journal Of Medical Genetics 1993, 46: 712-714. PMID: 8362915, DOI: 10.1002/ajmg.1320460623.Peer-Reviewed Original ResearchMalignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases
Wanebo J, Malik J, Vandenberg S, Wanebo H, Driesen N, Persing J. Malignant peripheral nerve sheath tumors. A clinicopathologic study of 28 cases. Cancer 1993, 71: 1247-1253. PMID: 8435801, DOI: 10.1002/1097-0142(19930215)71:4<1247::aid-cncr2820710413>3.0.co;2-s.Peer-Reviewed Original ResearchConceptsMalignant peripheral nerve sheath tumorDisease-free survivalSurgical marginsTumor sizeTumor locationSurvival timeMedian disease-free survival timeBetter disease-free survivalMedian overall survival timePeripheral nerve sheath tumorsDisease-free survival timeVirginia Health Sciences CenterAdjuvant radiation therapyExtent of surgeryWide surgical marginsNerve sheath tumorsOverall survival timeQuality of marginsNeurofibromatosis type 1Type of treatmentHealth Sciences CenterAggressive surgeryClinicopathologic studyOverall survivalPatient age