2022
PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development
Grinman DY, Boras-Granic K, Takyar FM, Dann P, Hens JR, Marmol C, Lee J, Choi J, Chodosh LA, Sola MEG, Wysolmerski JJ. PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development. Breast Cancer Research 2022, 24: 30. PMID: 35440032, PMCID: PMC9020078, DOI: 10.1186/s13058-022-01523-1.Peer-Reviewed Original ResearchConceptsOverexpression of PTHrPSecretory differentiationEpithelial cellsPTHrP overexpressionTumor latencyBreast cancerMammary epithelial cellsType 1 PTH/PTHrP receptorMMTV-PyMT breast cancer modelPTH/PTHrP receptorMMTV-PyMT miceMammary tumor developmentBreast cancer riskBreast cancer biologyExpression of PTHrPHormone-related proteinHuman breast cancerBreast cancer modelE74-like factor 5Normal mammary epithelial cellsBreast cancer progressionMouse mammary tumorsExpression of markersAlveolar epithelial cellsLuminal epithelial cells
2014
Embryonic cells contribute directly to the quiescent stem cell population in the adult mouse mammary gland
Boras-Granic K, Dann P, Wysolmerski JJ. Embryonic cells contribute directly to the quiescent stem cell population in the adult mouse mammary gland. Breast Cancer Research 2014, 16: 487. PMID: 25467960, PMCID: PMC4308878, DOI: 10.1186/s13058-014-0487-6.Peer-Reviewed Original ResearchConceptsAdult mammary glandMammary glandLabel-retaining cellsCell populationsFuture breast cancer riskStem cellsDNA label retentionBreast cancer riskStem cell populationEdU-labeled cellsEmbryonic day 18.5Label retaining cellsAdult mouse mammary glandStem/progenitor cellsMammary stem cellsStem/progenitor cell populationsSecondary mammospheresEmbryonic day 14.5Fetal exposureMouse mammary glandOvarian hormonesQuiescent stem cell populationMulti-potent stem cellsCancer riskBasal markers