2010
PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer
VanHouten J, Sullivan C, Bazinet C, Ryoo T, Camp R, Rimm DL, Chung G, Wysolmerski J. PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 11405-11410. PMID: 20534448, PMCID: PMC2895115, DOI: 10.1073/pnas.0911186107.Peer-Reviewed Original ResearchConceptsPMCA2 expressionBreast cancerT47D breast cancer cellsIntracellular calcium levelsBreast cancer progressionBreast cancer cellsEpithelial cell apoptosisPoor outcomeIntracellular calciumCalcium levelsMammary gland involutionCancer progressionCell apoptosisCancer cellsMammary involutionApoptosisGland involutionCancerMammary epithelial cell apoptosisOutcomesPMCA2Triggers apoptosisApical surfaceExpressionOverexpression
1996
Defining the roles of parathyroid hormone-related protein in normal physiology
Philbrick WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiological Reviews 1996, 76: 127-173. PMID: 8592727, DOI: 10.1152/physrev.1996.76.1.127.BooksConceptsHormone-related proteinHumoral hypercalcemiaParathyroid hormone-related proteinSmooth muscle toneTransepithelial calcium transportMuscle tonePhysiological functionsAutocrine roleFetal lifeOwn receptorNormal physiological functionPTHrPPTHrP geneNormal tissuesCalcium transportNormal physiologyHypercalcemiaMalignancyRegulation of tissueCancerProhormone convertasesTissueVast majorityPosttranslational processingReview
1995
Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development
Wysolmerski J, McCaughern-Carucci J, Daifotis A, Broadus A, Philbrick W. Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development. Development 1995, 121: 3539-3547. PMID: 8582268, DOI: 10.1242/dev.121.11.3539.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCell Culture TechniquesDrug ImplantsEpitheliumFemaleGene ExpressionImmunohistochemistryMammary Glands, AnimalMesodermMiceMice, TransgenicMolecular Sequence DataMorphogenesisParathyroid HormoneParathyroid Hormone-Related ProteinPolymerase Chain ReactionProteinsReceptors, Parathyroid HormoneSignal TransductionConceptsHormone-related proteinBreast developmentTransgenic miceParathyroid hormoneMyoepithelial cellsPTH/PTHrP receptorParathyroid hormone-related proteinMammary glandMammary duct systemOverexpression of PTHrPNormal breast developmentSlow-release pelletsEffects of PTHrPNormal fetal tissuesMammary gland developmentHumoral hypercalcemiaBreast hypoplasiaTumor productsPTHrP receptorNormal miceLobuloalveolar developmentTerminal ductsPTHrPFetal tissuesMice impairs
1993
Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene.
Vasavada RC, Wysolmerski JJ, Broadus AE, Philbrick WM. Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene. Endocrinology 1993, 7: 273-82. PMID: 8469240, DOI: 10.1210/mend.7.2.8469240.Peer-Reviewed Original ResearchConceptsExon 1cPeptide genesGC-rich promoter elementsCis-regulatory sequencesHuman parathyroid hormone-related peptide geneGC-rich promoterHandful of genesPrimer extension analysisHuman renal carcinoma cellsCanonical TATARenal carcinoma cellsFunctional dissectionCAAT sequencesHuman PTHrP genePutative promoterDNA 5Regulatory sequencesExtension analysisPromoter elementsGene promoterCAT geneGenomic DNAExon 1AAcetyltransferase constructsPrimer extension