2001
Calpain proteolysis of αII-spectrin in the normal adult human brain
Huh G, Glantz S, Je S, Morrow J, Kim J. Calpain proteolysis of αII-spectrin in the normal adult human brain. Neuroscience Letters 2001, 316: 41-44. PMID: 11720774, DOI: 10.1016/s0304-3940(01)02371-0.Peer-Reviewed Original ResearchConceptsAdult human brainCalpain activationEvident neurological diseaseHuman brainCortical gray matterLong-term potentiationNormal adult human brainDendrites of neuronsCerebellar Purkinje cellsCalpain processingReactive astrocytesCerebral cortexPyramidal neuronsSynaptic remodelingClinical conditionsNeuronal apoptosisAdult brainPositive cellsNeurological diseasesGray matterPurkinje cellsTopographic distributionAlphaII-spectrinBrainCalpain proteolysis
1999
Transforming Growth Factor β Induces Caspase 3-independent Cleavage of αII-Spectrin (α-Fodrin) Coincident with Apoptosis*
Brown T, Patil S, Cianci C, Morrow J, Howe P. Transforming Growth Factor β Induces Caspase 3-independent Cleavage of αII-Spectrin (α-Fodrin) Coincident with Apoptosis*. Journal Of Biological Chemistry 1999, 274: 23256-23262. PMID: 10438500, DOI: 10.1074/jbc.274.33.23256.Peer-Reviewed Original ResearchConceptsAlphaII-spectrinBroad-spectrum caspase inhibitorDistinct apoptotic pathwaysImmature B cell linesOnset of apoptosisCaspase-3 activationInduction of apoptosisPotent growth inhibitorNovel caspaseCaspase inhibitorsWEHI-231Cytoskeletal actinApoptotic pathwayB cell linesNovel substrateCell deathGrowth factor betaFirst direct evidenceCaspase-3ApoptosisCell linesCaspasesGrowth inhibitorFactor betaFirst evidence
1998
Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells*
Wang K, Posmantur R, Nath R, McGinnis K, Whitton M, Talanian R, Glantz S, Morrow J. Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells*. Journal Of Biological Chemistry 1998, 273: 22490-22497. PMID: 9712874, DOI: 10.1074/jbc.273.35.22490.Peer-Reviewed Original Research