1986
Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.
Pober JS, Gimbrone MA, Lapierre LA, Mendrick DL, Fiers W, Rothlein R, Springer TA. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. The Journal Of Immunology 1986, 137: 1893-6. PMID: 3091693, DOI: 10.4049/jimmunol.137.6.1893.Peer-Reviewed Original ResearchConceptsTumor necrosis factorIFN-gammaHuman umbilical vein endothelialNecrosis factorIL-1Interleukin-1HUVE cellsImmune interferonIntercellular adhesion molecule-1Endothelial cellsDifferent immune mediatorsAdhesion molecule-1Murine monoclonal antibodiesHuman endothelial cellsImmune mediatorsPattern of activationActivation antigensAntigenic modulationB antigensDifferent lymphokinesMolecule-1Monoclonal antibodiesProgressive increaseInterferonAntigenInduction and detection of a human endothelial activation antigen in vivo.
Cotran RS, Gimbrone MA, Bevilacqua MP, Mendrick DL, Pober JS. Induction and detection of a human endothelial activation antigen in vivo. Journal Of Experimental Medicine 1986, 164: 661-666. PMID: 3723080, PMCID: PMC2188244, DOI: 10.1084/jem.164.2.661.Peer-Reviewed Original ResearchConceptsEndothelial activation antigenActivation antigensSequential skin biopsiesStrong positive stainingHuman umbilical vein endothelial cell culturesEndothelial cell functionLymph nodesHypersensitivity reactionsSkin biopsiesInflammatory reactionImmunoperoxidase techniqueVascular endotheliumPositive stainingEndothelial cell culturesNormal endotheliumMurine mAbsUseful markerH4/18EndotheliumAntigenCell functionSkinPathological tissuesHuman skinTissuePhysiologic Regulation of Class II Major Histocompatibility Complex Gene Expression
Collins T, Pober J, Strominger J. Physiologic Regulation of Class II Major Histocompatibility Complex Gene Expression. 1986, 14-31. DOI: 10.1007/978-3-642-70367-6_2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsClass II determinantsNominal antigenMajor histocompatibility complexSpecific effector cellsClass II major histocompatibility complexT helper cellsAntigen-presenting cellsClass II antigensCase of transplantationMajor histocompatibility complex gene expressionT-inducer cellsClass II major histocompatibility complex gene expressionT cell antigen receptorAccessory capacityEffector cellsAllogeneic responseHelper cellsInducer cellsII antigensImmune responsivenessImmune systemCell antigen receptorAntigenAntigen receptorHistocompatibility complex
1983
Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon.
Pober JS, Gimbrone MA, Cotran RS, Reiss CS, Burakoff SJ, Fiers W, Ault KA. Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon. Journal Of Experimental Medicine 1983, 157: 1339-1353. PMID: 6403654, PMCID: PMC2186979, DOI: 10.1084/jem.157.4.1339.Peer-Reviewed Original ResearchConceptsAllogeneic T cellsT cellsIa antigensEndothelial cellsPeripheral blood mononuclear cellsBlood mononuclear cellsCultured human umbilical vein endothelial cellsExpression of IaActivated T cellsHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsAllograft rejectionVein endothelial cellsGamma interferon geneFluorescence flow cytometryHuman gamma interferonMononuclear cellsImmune responseGamma interferonVascular endotheliumIa expressionFlow cytometryImmune interferonMonoclonal antibodiesAntigen
1981
Purification of HLA-A2 antigen, fluorescent labeling of its intracellular region, and demonstration of an interaction between fluorescently labeled HLA-A2 antigen and lymphoblastoid cell cytoskeleton proteins in vitro.
Pober J, Guild B, Strominger J, Veatch W. Purification of HLA-A2 antigen, fluorescent labeling of its intracellular region, and demonstration of an interaction between fluorescently labeled HLA-A2 antigen and lymphoblastoid cell cytoskeleton proteins in vitro. Biochemistry 1981, 20: 5625-33. PMID: 6975122, DOI: 10.1021/bi00522a042.Peer-Reviewed Original Research
1978
Phosphorylation in vivo and in vitro of human histocompatibility antigens (HLA-A and HLA-B) in the carboxy-terminal intracellular domain.
Pober JS, Guild BC, Strominger JL. Phosphorylation in vivo and in vitro of human histocompatibility antigens (HLA-A and HLA-B) in the carboxy-terminal intracellular domain. Proceedings Of The National Academy Of Sciences Of The United States Of America 1978, 75: 6002-6006. PMID: 282620, PMCID: PMC393105, DOI: 10.1073/pnas.75.12.6002.Peer-Reviewed Original Research