2023
MicroRNA-1 protects the endothelium in acute lung injury
Korde A, Haslip M, Pednekar P, Khan A, Chioccioli M, Mehta S, Lopez-Giraldez F, Bermejo S, Rojas M, Dela Cruz C, Matthay M, Pober J, Pierce R, Takyar S. MicroRNA-1 protects the endothelium in acute lung injury. JCI Insight 2023, 8: e164816. PMID: 37737266, PMCID: PMC10561733, DOI: 10.1172/jci.insight.164816.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeAcute lung injuryVascular endothelial growth factorAngiopoietin-2Lung injuryAcute injuryMiR-1MicroRNA-1Endothelial cell-specific overexpressionSevere endothelial dysfunctionRespiratory distress syndromeSurvival of miceIntrinsic protective effectContext of injuryCell-specific overexpressionEndothelial growth factorFamily member 3Pneumonia cohortMiR-1 targetsEndothelial dysfunctionDistress syndromeBarrier dysfunctionCapillary leakProtective effectSevere form
2011
Vascular Endothelial Cells as Immunological Targets in Atheroscleroisis
Fogal B, Pober J. Vascular Endothelial Cells as Immunological Targets in Atheroscleroisis. 2011, 87-114. DOI: 10.1007/978-3-7091-0338-8_6.Peer-Reviewed Original ResearchSequelae of atherosclerosisProgression of atherosclerosisChronic inflammatory responseVessel wall toneProcess of atherogenesisImmune system cellsVascular endothelial cellsEndothelial dysfunctionAtherosclerotic processAltered endotheliumImmunological targetsInflammatory responseImpaired endotheliumWall toneImmune responseAdaptive immunityVascular permeabilityAtherosclerotic plaquesVascular endotheliumBlood fluidityImmune systemSystem cellsAtherosclerosisArterial wallEndothelial cells
2008
Chapter 2 Physiology and Pathobiology of Microvascular Endothelium
Pober J. Chapter 2 Physiology and Pathobiology of Microvascular Endothelium. 2008, 37-55. DOI: 10.1016/b978-0-12-374530-9.00002-4.Peer-Reviewed Original ResearchMicrovascular ECsVascular ECsRegulation of inflammationType II activationEarly activation eventsPlastic cell typeCell typesEndothelial dysfunctionInflammatory processAdaptive immunityChapter 2 PhysiologyBlood flowMicrovascular endotheliumVascular endotheliumBlood fluidityInflammation processEpithelial-like cellsHost defenseInflammationEntire circulatory systemCirculatory systemDysfunctionInjuryEndotheliumBlood
2006
Endothelial Cell Dysfunction, Injury and Death
Pober JS, Min W. Endothelial Cell Dysfunction, Injury and Death. Handbook Of Experimental Pharmacology 2006, 176/II: 135-156. PMID: 16999227, DOI: 10.1007/3-540-36028-x_5.Peer-Reviewed Original ResearchConceptsTumor necrosis factorCytolytic T lymphocytesEC injuryEndothelial cellsReactive oxygen speciesEndothelial cell dysfunctionMacrophage-derived cytokinesVascular endothelial cellsEndothelial dysfunctionNecrosis factorCell dysfunctionT lymphocytesInjuryCommon mediatorInflammationDysfunctionDeathOxygen speciesCytokinesLymphocytesNeutrophilsDifferent agentsBiochemical pathways