2007
Tumor Necrosis Factor
Pober J. Tumor Necrosis Factor. 2007, 261-265. DOI: 10.1017/cbo9780511546198.032.Peer-Reviewed Original ResearchHemorrhagic necrosisNecrosis factorMediator of cachexiaMediators of inflammationTumor necrosis factorPrimary cellular sourceAdaptive immune systemTNF-like moleculeTime of cloningMajor histocompatibility complexPeyer's patchesEndogenous mediatorsT lymphocytesMast cellsParasitic infectionsTNFBacterial productsExperimental tumorsImmune systemMononuclear phagocytesCellular sourceSmall intestineHistocompatibility complexTNF geneRelated receptors
2006
Endothelial Cell Dysfunction, Injury and Death
Pober JS, Min W. Endothelial Cell Dysfunction, Injury and Death. Handbook Of Experimental Pharmacology 2006, 176/II: 135-156. PMID: 16999227, DOI: 10.1007/3-540-36028-x_5.Peer-Reviewed Original ResearchConceptsTumor necrosis factorCytolytic T lymphocytesEC injuryEndothelial cellsReactive oxygen speciesEndothelial cell dysfunctionMacrophage-derived cytokinesVascular endothelial cellsEndothelial dysfunctionNecrosis factorCell dysfunctionT lymphocytesInjuryCommon mediatorInflammationDysfunctionDeathOxygen speciesCytokinesLymphocytesNeutrophilsDifferent agentsBiochemical pathways
2003
Combining altered levels of effector transcripts in circulating T cells with a marker of endothelial injury is specific for active graft-versus-host disease
Biedermann BC, Tsakiris DA, Gregor M, Pober JS, Gratwohl A. Combining altered levels of effector transcripts in circulating T cells with a marker of endothelial injury is specific for active graft-versus-host disease. Bone Marrow Transplantation 2003, 32: 1077-1084. PMID: 14625579, DOI: 10.1038/sj.bmt.1704258.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersCase-Control StudiesEndothelium, VascularFas Ligand ProteinGraft vs Host DiseaseHematopoietic Stem Cell TransplantationInterferon-gammaLymphocyte ActivationMembrane GlycoproteinsMolecular Diagnostic TechniquesRNA, MessengerSensitivity and SpecificitySurvivorsT-Lymphocytes, CytotoxicTransplantation, HomologousVon Willebrand FactorConceptsCytotoxic T lymphocytesEndothelial injuryT cell activationT cellsT lymphocytesHost diseaseSCT recipientsAllogeneic stem cell transplantationAllospecific cytotoxic T lymphocytesIFN-γ transcript levelsActive chronic GVHDEndothelial injury resultsCD8 T lymphocytesCD8 T cellsCD4 T cellsLong-term survivorsStem cell transplantationImportant effector cellsVon Willebrand factor plasma levelsAge-matched controlsVascular endothelial cellsChronic GVHDActive graftEffector cellsCell transplantation
2000
IL-11 Activates Human Endothelial Cells to Resist Immune-Mediated Injury
Mahboubi K, Biedermann B, Carroll J, Pober J. IL-11 Activates Human Endothelial Cells to Resist Immune-Mediated Injury. The Journal Of Immunology 2000, 164: 3837-3846. PMID: 10725745, DOI: 10.4049/jimmunol.164.7.3837.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDCells, CulturedComplement System ProteinsCytokine Receptor gp130Cytotoxicity, ImmunologicDNA-Binding ProteinsDose-Response Relationship, ImmunologicEndothelium, VascularEnzyme ActivationHumansImmunity, InnateInflammation MediatorsInterleukin-11Interleukin-11 Receptor alpha SubunitMembrane GlycoproteinsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein KinasesNF-kappa BPhosphorylationReceptors, InterleukinReceptors, Interleukin-11Signal TransductionSTAT1 Transcription FactorSTAT3 Transcription FactorT-Lymphocytes, CytotoxicTrans-ActivatorsTyrosineUmbilical VeinsConceptsIL-11Mitogen-activated protein kinaseP44 mitogen-activated protein kinaseImmune-Mediated InjuryCytolytic T lymphocytesNF-kappaB activationGp130-signaling cytokinesInflammatory injuryHuman endothelial cellsIL-11 receptorProinflammatory responseMolecule expressionT lymphocytesICAM-1Maximal responseE-selectinMHC AbsVivo modelNF-kappaBEndothelial cellsTyrosine phosphorylationPhospho-STAT3Cultured HUVECsInjuryKinase 1 inhibitor
1999
Immunobiology of human vascular endothelium
Pober J. Immunobiology of human vascular endothelium. Immunologic Research 1999, 19: 225-232. PMID: 10493176, DOI: 10.1007/bf02786490.Peer-Reviewed Original ResearchConceptsVascular endothelial cellsEndothelial cellsImmune reactionsCell-mediated immune reactionsPeptide-major histocompatibility complex complexesImmune effector mechanismsMemory T cellsSecondary immune reactionT cell signalsConsequences of infectionHuman vascular endotheliumHuman T lymphocytesHuman tissue specimensAllograft rejectionIntravascular coagulationAllogeneic transplantationEffector cellsNew effector functionsEffector mechanismsLeukocyte recruitmentImmune surveillanceT cellsT lymphocytesPeripheral tissuesEffector functions
1998
Human endothelial cells induce and regulate cytolytic T cell differentiation.
Biedermann B, Pober J. Human endothelial cells induce and regulate cytolytic T cell differentiation. The Journal Of Immunology 1998, 161: 4679-87. PMID: 9794397, DOI: 10.4049/jimmunol.161.9.4679.Peer-Reviewed Original ResearchConceptsB lymphoblastoid cellsEndothelial cellsHuman endothelial cellsSame donorT cellsProliferation of CD8IFN-gamma secretionCultured human endothelial cellsT cell differentiationT cell growthAllogeneic CD8CTL responsesPerforin expressionCTL differentiationPresence of ECT lymphocytesAllospecific CTLCD8CTLEfficient stimulatorsLymphoblastoid cellsCell numberReproducible frequencyCell growthInput cell number
1991
Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells.
Salomon RN, Hughes CC, Schoen FJ, Payne DD, Pober JS, Libby P. Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells. American Journal Of Pathology 1991, 138: 791-8. PMID: 2012171, PMCID: PMC1886118.Peer-Reviewed Original ResearchConceptsHuman cardiac allograftsCoronary arteryT lymphocytesCardiac allograftsEndothelial cellsT cellsChronic immune reactionsDonor coronary arteriesRecipient T lymphocytesRegional immune responsesClass II major histocompatibility complexGraft endothelial cellsSmooth muscle cell proliferationAllogeneic T cellsAbility of HLAHuman arteriesLong-term survivalMuscle cell proliferationCoronary arterial endotheliumMajor histocompatibility complexNormal human arteriesTypical atherosclerosisOcclusive diseaseHLA-DRTransplanted heartsImmunologic Interactions of T Lymphocytes with Vascular Endothelium
Pober J, Cotran R. Immunologic Interactions of T Lymphocytes with Vascular Endothelium. Advances In Immunology 1991, 50: 261-302. PMID: 1950797, DOI: 10.1016/s0065-2776(08)60827-5.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMemory T cellsT cellsVascular endotheliumPrimary antigen-presenting cellsAntigen-presenting functionAntigen-presenting cellsNaive T cellsContext of transplantationEffective T cell activationCultured human endothelial cellsT cell activationVivo immune systemLymph nodesHuman endothelial cellsHypersensitivity reactionsImmunologic interactionsIL-8Preferential homingT lymphocytesInflammatory sitesAntigen specificityImmune systemRejection reactionCell activationMemory responses
1984
Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens
Pober JS, Gimbrone MA, Collins T, Cotran RS, Ault KA, Fiers W, Krensky AM, Clayberger C, Reiss C, Burakoff SJ. Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens. Immunobiology 1984, 168: 483-494. PMID: 6397428, DOI: 10.1016/s0171-2985(84)80132-1.Peer-Reviewed Original ResearchConceptsClass II antigensVascular endothelial cellsMajor histocompatibility complexII antigensT cellsClass II moleculesHuman vascular endothelial cellsActivated T cellsEndothelial cellsStromal cellsImmune interferonT lymphocytesAntigen-specific T cellsPeripheral blood T lymphocytesClass IHelper T cell clonesImmune accessory functionNon-MHC antigensWithdrawal of interferonClass II major histocompatibility complexCultured human vascular endothelial cellsT cell responsesVascular smooth muscle cellsBlood T lymphocytesHuman class II antigensHuman cytolytic T lymphocyte interactions with vascular endothelium and fibroblasts: role of effector and target cell molecules.
Collins T, Krensky AM, Clayberger C, Fiers W, Gimbrone MA, Burakoff SJ, Pober JS. Human cytolytic T lymphocyte interactions with vascular endothelium and fibroblasts: role of effector and target cell molecules. The Journal Of Immunology 1984, 133: 1878-84. PMID: 6432903, DOI: 10.4049/jimmunol.133.4.1878.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntigens, SurfaceBinding Sites, AntibodyCell CommunicationCytotoxicity, ImmunologicEndotheliumFibroblastsHistocompatibility Antigens Class IIHLA-DR AntigensHumansIndiumInterferon-gammaLymphocyte Function-Associated Antigen-1RadioisotopesT-LymphocytesT-Lymphocytes, CytotoxicUmbilical VeinsConceptsCytolytic T lymphocytesVascular endotheliumCultured human vascular endotheliumLFA-1LFA-2Human cytolytic T lymphocytesHuman CTL linesT lymphocyte interactionsCell typesSame CTL clonesImportant target cellsTarget cell structuresHuman vascular endotheliumLymphoid targetsHost diseaseAllograft rejectionImmune injuryHLA-DRCell surface moleculesCTL linesCTL clonesT lymphocytesLymphocyte interactionsTarget cell typeLFA-3
1983
Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon
Pober J, Collins T, Gimbrone M, Cotran R, Gitlin J, Fiers W, Clayberger C, Krensky A, Burakoff S, Reiss C. Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. Nature 1983, 305: 726-729. PMID: 6415484, DOI: 10.1038/305726a0.Peer-Reviewed Original ResearchConceptsCytolytic T lymphocytesRecombinant immune interferonIa antigensT cellsIa expressionAlloreactive cytolytic T lymphocytesClass II major histocompatibility complex antigensT-lymphocyte-mediated responsesImmune interferonEndothelial cellsMajor histocompatibility complex antigensForeign class IHistocompatibility complex antigensHuman vascular endothelialHuman umbilical vein endothelial cellsHUVE cellsCapillary endothelial cellsUmbilical vein endothelial cellsHuman T cellsImmunological cell typesAllograft rejectionVein endothelial cellsOrgan graftsT lymphocytesComplex antigens