1995
IL-4 induction of VCAM-1 on endothelial cells involves activation of a protein tyrosine kinase.
Palmer-Crocker RL, Pober JS. IL-4 induction of VCAM-1 on endothelial cells involves activation of a protein tyrosine kinase. The Journal Of Immunology 1995, 154: 2838-45. PMID: 7533184, DOI: 10.4049/jimmunol.154.6.2838.Peer-Reviewed Original ResearchConceptsVascular cell adhesion molecule-1VCAM-1 expressionEndothelial cellsIL-4 inductionIL-4IL-4R.Cell adhesion molecule-1Pretreatment of ECTreatment of ECIL-4 concentrationsAdhesion molecule-1Cultured human endothelial cellsHerbimycin ATime of treatmentHuman endothelial cellsTyrosine kinaseMolecule-1Western blotProtein tyrosine kinasesTyrosine phosphorylationIL-4-induced tyrosine phosphorylationAnti-phosphotyrosine immunoprecipitatesReplicate wells
1993
Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration.
Slowik MR, De Luca LG, Fiers W, Pober JS. Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration. American Journal Of Pathology 1993, 143: 1724-30. PMID: 7504889, PMCID: PMC1887273.Peer-Reviewed Original ResearchConceptsEndothelial leukocyte adhesion molecule-1Endothelial cellsHuman endothelial cellsTumor necrosis factor concentrationsMonoclonal antibodiesNecrosis factor concentrationsLeukocyte adhesion molecule-1Major histocompatibility complex moleculesActivation of ECTumor necrosis factorAdhesion molecule-1Class I major histocompatibility complex moleculesLeukocyte adhesion moleculesTumor necrosis factor receptorELAM-1 inductionRecombinant human TNFHistocompatibility complex moleculesNecrosis factor receptorCultured endothelial cellsP75 receptorTumor necrosisNecrosis factorMolecule-1Receptor typesTNF receptor
1992
Thrombin and histamine rapidly stimulate the phosphorylation of the myristoylated alanine‐rich C‐kinase substrate in human umbilical vein endothelial cells: Evidence for distinct patterns of protein kinase activation
Jacobson B, Pober J, Fenton J, Ewenstein B. Thrombin and histamine rapidly stimulate the phosphorylation of the myristoylated alanine‐rich C‐kinase substrate in human umbilical vein endothelial cells: Evidence for distinct patterns of protein kinase activation. Journal Of Cellular Physiology 1992, 152: 166-176. PMID: 1320036, DOI: 10.1002/jcp.1041520121.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedDose-Response Relationship, DrugElectrophoresis, Polyacrylamide GelEndothelium, VascularEnzyme ActivationHistamineHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMolecular WeightMyristoylated Alanine-Rich C Kinase SubstratePhosphorylationPrecipitin TestsProtein KinasesProteinsReceptors, Cell SurfaceThrombin
1991
Identification of a novel high molecular weight protein preferentially expressed by sinusoidal endothelial cells in normal human tissues.
Goerdt S, Walsh LJ, Murphy GF, Pober JS. Identification of a novel high molecular weight protein preferentially expressed by sinusoidal endothelial cells in normal human tissues. Journal Of Cell Biology 1991, 113: 1425-1437. PMID: 2045420, PMCID: PMC2289031, DOI: 10.1083/jcb.113.6.1425.Peer-Reviewed Original ResearchConceptsSinusoidal endothelial cellsEndothelial cellsPeripheral blood mononuclear cellsMS-1 antigenDendritic cell populationsEndothelial cell antigensBlood mononuclear cellsHigh endothelial venulesHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsVein endothelial cellsLymph nodesKG-1 cellsNormal human tissuesMononuclear cellsLymphoid tissueAdrenal cortexEndothelial venulesCell line KG-1Cell line U937Cell antigensSplenic tissueSinusoidal endotheliumSplenic extractSpleen
1986
Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells.
Pober JS, Bevilacqua MP, Mendrick DL, Lapierre LA, Fiers W, Gimbrone MA. Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells. The Journal Of Immunology 1986, 136: 1680-7. PMID: 3485132, DOI: 10.4049/jimmunol.136.5.1680.Peer-Reviewed Original Research