1989
ENDOTHELIAL CELL ACTIVATION AND HIGH INTERLEUKIN-1 SECRETION IN THE PATHOGENESIS OF ACUTE KAWASAKI DISEASE
Leung D, Kurt-Jones E, Newburger J, Cotran R, Burns J, Pober J. ENDOTHELIAL CELL ACTIVATION AND HIGH INTERLEUKIN-1 SECRETION IN THE PATHOGENESIS OF ACUTE KAWASAKI DISEASE. The Lancet 1989, 334: 1298-1302. PMID: 2480498, DOI: 10.1016/s0140-6736(89)91910-7.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, SurfaceCell AdhesionCell Adhesion MoleculesChild, PreschoolEndothelium, VascularE-SelectinFemaleGamma-GlobulinsHLA-DQ AntigensHumansImmunization, PassiveIntercellular Adhesion Molecule-1Interleukin-1MaleMembrane GlycoproteinsMucocutaneous Lymph Node SyndromeReceptors, ImmunologicSkinConceptsEndothelial cell activationCoronary artery abnormalitiesCell activationInterleukin-1Gammaglobulin treatmentArtery abnormalitiesKawasaki diseaseAcute Kawasaki disease patientsPeripheral blood mononuclear cellsEndothelial cellsCytotoxic antibody activityIntravenous gammaglobulin treatmentKawasaki disease patientsAcute Kawasaki diseaseEndothelial cell antigensBlood mononuclear cellsInterleukin-1 secretionTumor necrosis factorIL-1 secretionEndothelial cell expressionSkin biopsy samplesMeans of immunoperoxidaseMucocutaneous symptomsPersistent feverClinical symptomsEffects of cytokines on vascular endothelium: Their role in vascular and immune injury
Cotran R, Pober J. Effects of cytokines on vascular endothelium: Their role in vascular and immune injury. Kidney International 1989, 35: 969-975. PMID: 2651773, DOI: 10.1038/ki.1989.80.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsAntineoplastic AgentsBiological FactorsCytokinesEndothelium, VascularHumansImmune System DiseasesInterleukin-2Mucocutaneous Lymph Node SyndromeVascular DiseasesConceptsEffects of cytokinesEndothelial cellsCytokine-induced effectsRenal injuryEndothelial functionImmune injuryEndothelial activationVascular toneRenal endotheliumImmune functionCell injuryVascular endotheliumCritical homeostatic functionsEndothelium participatesClinical settingHomeostatic functionsTranscapillary permeabilityCytokinesInjurySpecific alterationsInflammationControl of proliferationHematopoietic cellsEndotheliumRecent studiesEndothelial activation in the pathogenesis of Kawasaki disease.
Leung DY, Cotran RS, Kurt-Jones E, Burns JC, Newburger JW, Pober JS. Endothelial activation in the pathogenesis of Kawasaki disease. Proceedings Of The Association Of American Physicians 1989, 102: 131-8. PMID: 2484114.Peer-Reviewed Original ResearchEndothelium, VascularGamma-GlobulinsHumansIn Vitro TechniquesInterleukin-1Models, BiologicalMucocutaneous Lymph Node SyndromeSkinTumor Necrosis Factor-alpha
1986
Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome.
Leung DY, Geha RS, Newburger JW, Burns JC, Fiers W, Lapierre LA, Pober JS. Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome. Journal Of Experimental Medicine 1986, 164: 1958-1972. PMID: 3491174, PMCID: PMC2188474, DOI: 10.1084/jem.164.6.1958.Peer-Reviewed Original ResearchMeSH KeywordsAntibodiesAntigens, SurfaceCell LineCell SurvivalChild, PreschoolEndotheliumFemaleGlycoproteinsHumansInfantInterleukin-1MaleMucocutaneous Lymph Node SyndromeTumor Necrosis Factor-alphaVeinsConceptsAcute Kawasaki syndromeTumor necrosis factorKawasaki syndromeHuman endothelial cellsIL-1Cytotoxic antibodiesImmune activationEndothelial cellsNecrosis factorTarget antigenComplement-dependent cytotoxic activityAcute febrile illnessEndothelial cell antigensVascular smooth muscle cellsAge-matched controlsMonocytes/macrophagesSmooth muscle cellsCultured vascular endothelial cellsVascular endothelial cellsComplement-mediated killingDiffuse vasculitisConvalescent phaseFebrile illnessAcute phaseVascular injuryImmunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon.
Leung DY, Collins T, Lapierre LA, Geha RS, Pober JS. Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon. Journal Of Clinical Investigation 1986, 77: 1428-1435. PMID: 3084559, PMCID: PMC424542, DOI: 10.1172/jci112454.Peer-Reviewed Original ResearchConceptsAcute Kawasaki syndromeKawasaki syndromeImmunoglobulin M antibodiesGamma-IFNVein endothelial cellsM antibodiesEndothelial cellsT cellsKS seraGamma interferonClass II major histocompatibility complex antigen expressionMajor histocompatibility complex antigen expressionComplement-dependent cytotoxic activityAnti-endothelial cell antibodiesHUVE cellsHuman dermal fibroblastsHuman saphenous vein smooth muscle cellsSaphenous vein smooth muscle cellsMarked immune activationSecrete gamma interferonSecretion of lymphokinesEndothelial cell antigensAge-matched controlsVein smooth muscle cellsActivated T cells