1986
High‐grade soft tissue sarcomas of the extremities
Potter D, Kinsella T, Glatstein E, Wesley R, White D, Seipp C, Chang A, Lack E, Costa J, Rosenberg S. High‐grade soft tissue sarcomas of the extremities. Cancer 1986, 58: 190-205. PMID: 3518911, DOI: 10.1002/1097-0142(19860701)58:1<190::aid-cncr2820580133>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH KeywordsActuarial AnalysisAdolescentAdultAgedAmputation, SurgicalAntineoplastic Combined Chemotherapy ProtocolsArmChildClinical Trials as TopicCombined Modality TherapyFemaleFollow-Up StudiesHumansLegMaleMiddle AgedNeoplasm MetastasisNeoplasm Recurrence, LocalPrognosisRandom AllocationSarcomaThighConceptsHigh-grade soft tissue sarcomasSoft tissue sarcomasNational Cancer InstituteLimb-sparing proceduresSignificant prognostic variablesOverall survivalAdjuvant chemotherapyTissue sarcomasPrognostic variablesDecreased overall survivalOutcomes of patientsDisease-free survivalMicroscopic marginsPostoperative radiotherapyFirst recurrenceProspective trialRecurrent diseaseSurgery BranchHistologic typeLocal excisionRandomized trialsPatient refusalTumor sizeCancer InstitutePatients
1985
A randomized, prospective trial of adjuvant chemotherapy in adults with soft tissue sarcomas of the head and neck, breast, and trunk
Glenn J, Kinsella T, Glatstein E, Tepper J, Baker A, Sugarbaker P, Sindelar W, Roth J, Brennan M, Costa J, Seipp C, Wesley R, Young R, Rosenberg S. A randomized, prospective trial of adjuvant chemotherapy in adults with soft tissue sarcomas of the head and neck, breast, and trunk. Cancer 1985, 55: 1206-1214. PMID: 3882217, DOI: 10.1002/1097-0142(19850315)55:6<1206::aid-cncr2820550612>3.0.co;2-e.Peer-Reviewed Original ResearchConceptsDisease-free survivalActuarial disease-free survivalOverall actuarial survivalChemotherapy armAdjuvant chemotherapyOverall survivalActuarial survivalApparent congestive heart failureAggressive local treatmentUse of chemotherapyCongestive heart failureSubgroup of patientsHigh-grade sarcomaSoft tissue sarcomasPostoperative radiotherapyProspective trialComplete resectionHeart failureAdditional patientsTreatment armsGross tumorProspective studyTissue sarcomasLocal treatmentChemotherapyResults of multimodality therapy of resectable soft-tissue sarcomas of the retroperitoneum.
Glenn J, Sindelar W, Kinsella T, Glatstein E, Tepper J, Costa J, Baker A, Sugarbaker P, Brennan M, Seipp C. Results of multimodality therapy of resectable soft-tissue sarcomas of the retroperitoneum. Surgery 1985, 97: 316-25. PMID: 3975851.Peer-Reviewed Original ResearchConceptsRandomized studyTwo-year actuarial survival ratesSurvival rateResectable soft tissue sarcomaSevere bone marrow suppressionAggressive multimodality treatmentResectable retroperitoneal sarcomasSevere radiation enteritisActuarial survival rateBone marrow suppressionCyclophosphamide-induced cystitisSoft tissue sarcomasAdjuvant chemotherapyChemotherapy armPostoperative chemotherapyRetroperitoneal sarcomaChemotherapy regimenMajor morbidityMultimodality therapyRadiation enteritisBowel resectionMarrow suppressionMultimodality treatmentMajor complicationsCardiac toxicity
1983
Prospective randomized evaluation of adjuvant chemotherapy in adults with soft tissue sarcomas of the extremities
Rosenberg S, Tepper J, Glatstein E, Costa J, Young R, Baker A, Brennan M, Demoss E, Seipp C, Sindelar W, Sugarbaker P, Wesley R. Prospective randomized evaluation of adjuvant chemotherapy in adults with soft tissue sarcomas of the extremities. Cancer 1983, 52: 424-434. PMID: 6344981, DOI: 10.1002/1097-0142(19830801)52:3<424::aid-cncr2820520307>3.0.co;2-8.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasDisease-free survivalAdjuvant chemotherapyChemotherapy groupOverall survivalTissue sarcomasPilot trialPatient groupRadiation therapyHigh-grade soft tissue sarcomasContinuous disease-free survivalLocal failureHigh-dose methotrexatePercent of patientsLimb-sparing surgeryImmediate postoperative periodProspective Randomized EvaluationWide local resectionPrevious pilot trialUnderwent amputationAdult patientsLocal resectionPostoperative periodLocal therapyActuarial analysis
1982
Small‐cell osteosarcoma
Martin S, Dwyer A, Kissane J, Costa J. Small‐cell osteosarcoma. Cancer 1982, 50: 990-996. PMID: 6953993, DOI: 10.1002/1097-0142(19820901)50:5<990::aid-cncr2820500529>3.0.co;2-r.Peer-Reviewed Original ResearchConceptsSmall cell osteosarcomaAdjuvant chemotherapyEwing's sarcomaEvidence of diseaseSymptoms of painForms of osteosarcomaClinical featuresOptimal therapyMonths durationRadiographic appearanceSarcomaTumorsRound cellsPatientsOsteoid matrixOsteosarcomaChemotherapyReceived radiationWide variationPainSurgeryTherapyLesionsSymptomsIncidenceThe Treatment of Soft-tissue Sarcomas of the Extremities
ROSENBERG S, TEPPER J, GLATSTEIN E, COSTA J, BAKER A, BRENNAM M, DEMOSS E, SEIPP C, SINDELAR W, SUGARBAKER P, WESLEY R. The Treatment of Soft-tissue Sarcomas of the Extremities. Annals Of Surgery 1982, 196: 305-315. PMID: 7114936, PMCID: PMC1352604, DOI: 10.1097/00000658-198209000-00009.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasHigh-grade soft tissue sarcomasLimb-sparing groupLimb-sparing resectionLocal recurrencePostoperative chemotherapyAdult patientsTissue sarcomasRadiation therapySurvival rateDisease-free survival ratesAdjuvant radiation therapyHigh-dose methotrexateLimb-sparing surgeryOverall survival rateProspective Randomized StudyWide local excisionJoint proximalAdjuvant chemotherapyResection groupPostoperative radiotherapyOverall survivalRandomized studyLocal excisionAmputation group
1981
Adjuvant Chemotherapy for Patients with Soft Tissue Sarcomas
Rosenberg S, Tepper J, Glatstein E, Costa J, Young R, Seipp C, Wesley R. Adjuvant Chemotherapy for Patients with Soft Tissue Sarcomas. Surgical Clinics Of North America 1981, 61: 1415-1423. PMID: 7031940, DOI: 10.1016/s0039-6109(16)42595-8.Peer-Reviewed Original Research