1994
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
Chaubert P, Benhattar J, Saraga E, Costa J. K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis. American Journal Of Pathology 1994, 144: 767-75. PMID: 8160776, PMCID: PMC1887244.Peer-Reviewed Original ResearchConceptsK-ras mutationsLongstanding ulcerative colitisUlcerative colitisP53 alterationsActive colitisDysplastic lesionsK-rasGenetic alterationsP53 gene alterationsP53 genetic alterationsCombination of immunohistochemistryK-ras geneNonneoplastic lesionsColorectal carcinomaInvasive carcinomaColonic carcinomaDysplastic mucosaEpithelial lesionsInvasive tumorsColitisSame patientCarcinomaSporadic carcinomasLesionsNontumor samplesPapillary Variant of Low-grade Mucoepidermoid Carcinoma—An Unusual Bronchial Neoplasm: A Light Microscopic, Ultrastructural, and Immunohistochemical Study
Guillou L, De Luze P, Zysset F, Costa J. Papillary Variant of Low-grade Mucoepidermoid Carcinoma—An Unusual Bronchial Neoplasm: A Light Microscopic, Ultrastructural, and Immunohistochemical Study. American Journal Of Clinical Pathology 1994, 101: 269-274. PMID: 8135181, DOI: 10.1093/ajcp/101.3.269.Peer-Reviewed Original ResearchConceptsLow-grade mucoepidermoid carcinomaMucoepidermoid carcinomaPapillary variantLow malignant potentialBronchial mucous gland adenomaElectron microscopic featuresMucous gland adenomaAppropriate therapyLower lobePapillary tumorsMalignant potentialImmunohistochemical studyDifferential diagnosisPostmortem examinationBronchial neoplasmsGland adenomaSurface epitheliumNeoplasm categoryLight microscopicCarcinomaMicroscopic featuresLesionsTumorsLobectomyPapillomas
1993
Prognostic significance of K-ras mutations in colorectal carcinoma
Benhattar J, Losi L, Chaubert P, Givel J, Costa J. Prognostic significance of K-ras mutations in colorectal carcinoma. Gastroenterology 1993, 104: 1044-1048. PMID: 8462792, DOI: 10.1016/0016-5085(93)90272-e.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrognostic significanceColorectal carcinomaK-ras geneRecurrent diseaseCodon 12Good prognostic factorAdvanced colorectal carcinomaPossible prognostic significanceHuman colorectal carcinomaPolymerase chain reaction-based techniquesDukes' BPrognostic factorsColorectal cancerPrimary tumorOverall prevalenceHigh riskPatientsRas mutationsCarcinomaHuman tumorsTumorsDiseasePrevalenceGGT
1992
Stability of K-ras mutations throughout the natural history of human colorectal cancer
Losi L, Benhattar J, Costa J. Stability of K-ras mutations throughout the natural history of human colorectal cancer. European Journal Of Cancer 1992, 28: 1115-1120. PMID: 1627381, DOI: 10.1016/0959-8049(92)90468-h.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrimary tumorRas mutationsNatural historyColorectal cancerTumor markersStable tumor markerHuman colorectal cancerDistant recurrenceRecurrent cancerRecurrent tumorsPolymerase chain reactionColorectal carcinomaCodon 12TumorsArchival tissueCancerChain reactionAllele-specific amplificationPatientsRecurrenceMarkersMutationsCarcinomaDisease
1991
Squamous Cell Carcinoma of the Lung in a Nonsmoking, Nonirradiated Patient with Juvenile Laryngotracheal Papillomatosis
Guillou L, Sahli R, Chaubert P, Monnier P, Cuttat J, Costa J. Squamous Cell Carcinoma of the Lung in a Nonsmoking, Nonirradiated Patient with Juvenile Laryngotracheal Papillomatosis. The American Journal Of Surgical Pathology 1991, 15: 891-898. PMID: 1659237, DOI: 10.1097/00000478-199109000-00010.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaMalignant transformationLaryngotracheal papillomatosisJuvenile papillomatosisCell carcinomaPrevious radiation therapySquamous cell papillomasHost immune responseSpontaneous malignant transformationPeribronchial lymphPulmonary infectionSmoking historyCell papillomasImmune responsePostmortem examinationChest wallRadiation therapyViral infectionPapillomatosisCarcinomaPatientsLungInfectionMolecular studiesLymph
1987
Gastric Dysplasia
Saraga E, Gardiol D, Costa J. Gastric Dysplasia. The American Journal Of Surgical Pathology 1987, 11: 788-796. PMID: 3661823, DOI: 10.1097/00000478-198710000-00006.Peer-Reviewed Original Research
1983
“Low grade” mucoepidermoid carcinoma of the bronchus with “high grade” biological behavior
Barsky S, Martin S, Matthews M, Gazdar A, Costa J. “Low grade” mucoepidermoid carcinoma of the bronchus with “high grade” biological behavior. Cancer 1983, 51: 1505-1509. PMID: 6825057, DOI: 10.1002/1097-0142(19830415)51:8<1505::aid-cncr2820510825>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsLow-grade histologic featuresMucoepidermoid carcinomaWidespread metastasesHistologic featuresBiological behaviorLow-grade mucoepidermoid carcinomaPrimary endobronchial tumorsHigh-grade lesionsLow-grade lesionsAggressive biological behaviorGrade mucoepidermoid carcinomaNumerous goblet cellsLow gradeGlycogen-rich cellsEndobronchial massEndobronchial tumorPrimary tumorMonomorphic cellsOriginal tumorMorphologic patternsNude miceGoblet cellsCarcinomaSubcutaneous tissueMetastasis
1982
Histopathological features of rapidly progressing breast carcinoma in Tunisia: A study of 94 cases
Costa J, Webber B, Levine P, Muenz L, O'Conor G, Tabbane F, Belhassen S, Kamaraju L, Mourali N. Histopathological features of rapidly progressing breast carcinoma in Tunisia: A study of 94 cases. International Journal Of Cancer 1982, 30: 35-37. PMID: 6288578, DOI: 10.1002/ijc.2910300107.Peer-Reviewed Original ResearchConceptsHistological featuresCutaneous inflammatory infiltrateNuclear grade 3Breast carcinoma patientsCases of carcinomaPercentage of casesNumber of mitosesInflammatory carcinomaCarcinoma patientsHistopathological featuresInflammatory infiltrateTumor emboliNuclear gradeRapid progressionBreast carcinomaGrade 3Clinical classificationTumor typesBreast tissueCarcinomaPatientsCutaneous permeationBreastDermisPresent study
1981
Risk of subsequent contralateral breast carcinoma in a population of patients with in‐situ breast carcinoma
Webber B, Heise H, Neifeld J, Costa J. Risk of subsequent contralateral breast carcinoma in a population of patients with in‐situ breast carcinoma. Cancer 1981, 47: 2928-2932. PMID: 6266644, DOI: 10.1002/1097-0142(19810615)47:12<2928::aid-cncr2820471232>3.0.co;2-5.Peer-Reviewed Original ResearchConceptsBreast carcinomaContralateral carcinomaSubsequent cancerContralateral breast carcinomaMajority of patientsPopulation of patientsSecond breast cancerNoninvasive breast carcinomaSitu breast carcinomaContralateral tumorsOverall survivalContralateral breastHistological typeSurvival figuresLobular carcinomaOpposite breastBreast cancerSitu carcinomaCarcinomaS. womenCancerPatientsBreastWomenMastectomy