2014
Genetic alterations in chondrosarcomas – keys to targeted therapies?
Samuel AM, Costa J, Lindskog DM. Genetic alterations in chondrosarcomas – keys to targeted therapies? Cellular Oncology 2014, 37: 95-105. PMID: 24458248, DOI: 10.1007/s13402-014-0166-8.Peer-Reviewed Original ResearchConceptsBenign cartilaginous lesionsCartilaginous lesionsMalignant transformationIhh/PTHrPTwo-hit scenarioPrimary bone tumorsGenetic alterationsDruggable molecular targetsKey genetic alterationsHuman tumor typesResultsCurrent dataBone tumorsMalignant tumorsSarcoma typesMalignant chondrosarcomasKey molecular changesNormal cell cycle controlTumor typesMalignant cellsChondrosarcoma developmentLesionsMolecular targetsTumorsEarly-stage eventsDifferentiation of chondrocytes
1991
Squamous Cell Carcinoma of the Lung in a Nonsmoking, Nonirradiated Patient with Juvenile Laryngotracheal Papillomatosis
Guillou L, Sahli R, Chaubert P, Monnier P, Cuttat J, Costa J. Squamous Cell Carcinoma of the Lung in a Nonsmoking, Nonirradiated Patient with Juvenile Laryngotracheal Papillomatosis. The American Journal Of Surgical Pathology 1991, 15: 891-898. PMID: 1659237, DOI: 10.1097/00000478-199109000-00010.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaMalignant transformationLaryngotracheal papillomatosisJuvenile papillomatosisCell carcinomaPrevious radiation therapySquamous cell papillomasHost immune responseSpontaneous malignant transformationPeribronchial lymphPulmonary infectionSmoking historyCell papillomasImmune responsePostmortem examinationChest wallRadiation therapyViral infectionPapillomatosisCarcinomaPatientsLungInfectionMolecular studiesLymph
1974
Effect of dexamethasone on herpes simplex virus type 2 infection in vitro
COSTA J, YEE C, TROOST T, RABSON A. Effect of dexamethasone on herpes simplex virus type 2 infection in vitro. Nature 1974, 252: 745-746. PMID: 4373659, DOI: 10.1038/252745a0.Peer-Reviewed Original ResearchConceptsHSV-2 infectionHerpes simplex virus type 2 infectionSimplex virus type 2 infectionVirus type 2 infectionEffect of corticosteroidsSimplex type 2Type 2 infectionEffect of dexamethasoneMouse mammary tumorsPresence of steroidsGlucocorticoid influencesEpidemiological evidenceMammary tumorsPhysiological dosesVirus-infected culturesType 2Plaque formationMalignant transformationViral strainsInfectionTypes of cellsMurine leukemia virusMouse embryo fibroblastsCorticosteroidsLeukemia virus