2020
Synovial Myxoma: Found in Canines, Rabbits, and Now Humans Too?: A Case Report.
Munger AM, Ibe IK, Rottmann D, Conway D, Costa J, Lindskog DM. Synovial Myxoma: Found in Canines, Rabbits, and Now Humans Too?: A Case Report. JBJS Case Connector 2020, 10: e0490. PMID: 32224675, DOI: 10.2106/jbjs.cc.19.00490.Peer-Reviewed Case Reports and Technical NotesConceptsSynovial myxomaCase reportRight knee painYear old womanCluster of differentiationLow proliferative activityAggressive massKnee painPathologic reviewIntralesional resectionArthroscopic synovectomyKnee aspirationSynovial cellsInfiltrative tumorsMyxoid stromaProliferative activityPainSynovectomyMyxomaSlow growingReportResectionPatientsEffusionHumans
2001
Detection of the Mutated K-Ras Biomarker in Colorectal Carcinoma
Doolittle B, Emanuel J, Tuttle C, Costa J. Detection of the Mutated K-Ras Biomarker in Colorectal Carcinoma. Experimental And Molecular Pathology 2001, 70: 289-301. PMID: 11418008, DOI: 10.1006/exmp.2001.2364.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorColorectal NeoplasmsDeoxyribonuclease EcoRIDNADNA, NeoplasmFecesGenes, rasHumansIndicators and ReagentsMutationPolymerase Chain ReactionPolymorphism, Single-Stranded ConformationalQuaternary Ammonium CompoundsReference ValuesReproducibility of ResultsSite-Specific DNA-Methyltransferase (Adenine-Specific)Trimethyl Ammonium CompoundsConceptsColorectal carcinomaStool samplesHealthy patientsK-rasReliable screening testDouble-blind formatK-ras mutationsWild-type K-rasK-ras oncogeneK-ras sequencesCommon malignancyCRC tumorsPolymerase chain reactionEarly lesionsStool DNANoninvasive screenScreening testTumor tissueGenetic biomarkersHuman stoolPatientsEarly detectionHigh false positive rateSingle-strand conformation polymorphismTissue DNA
1996
Angiotropic large cell lymphoma presenting as primary adrenal insufficiency
Chu P, Costa J, Lachman M. Angiotropic large cell lymphoma presenting as primary adrenal insufficiency. Human Pathology 1996, 27: 209-211. PMID: 8617467, DOI: 10.1016/s0046-8177(96)90379-2.Peer-Reviewed Original ResearchConceptsPrimary adrenal insufficiencyLarge cell lymphomaAdrenal insufficiencyCell lymphomaAngiotropic large cell lymphomaSevere metabolic acidosisNeoplastic lymphoid cellsB-cell lineageLymphoma PresentingUnexplained hypotensionMultiorgan involvementUnrecognized causeAdrenal glandMetabolic acidosisCortical vesselsHormone deficiencyDifferential diagnosisLymphoid cellsParenchymal cellsPatientsLymphomaInsufficiencyHypotensionCellsPresenting
1993
Prognostic significance of K-ras mutations in colorectal carcinoma
Benhattar J, Losi L, Chaubert P, Givel J, Costa J. Prognostic significance of K-ras mutations in colorectal carcinoma. Gastroenterology 1993, 104: 1044-1048. PMID: 8462792, DOI: 10.1016/0016-5085(93)90272-e.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrognostic significanceColorectal carcinomaK-ras geneRecurrent diseaseCodon 12Good prognostic factorAdvanced colorectal carcinomaPossible prognostic significanceHuman colorectal carcinomaPolymerase chain reaction-based techniquesDukes' BPrognostic factorsColorectal cancerPrimary tumorOverall prevalenceHigh riskPatientsRas mutationsCarcinomaHuman tumorsTumorsDiseasePrevalenceGGT
1992
Stability of K-ras mutations throughout the natural history of human colorectal cancer
Losi L, Benhattar J, Costa J. Stability of K-ras mutations throughout the natural history of human colorectal cancer. European Journal Of Cancer 1992, 28: 1115-1120. PMID: 1627381, DOI: 10.1016/0959-8049(92)90468-h.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrimary tumorRas mutationsNatural historyColorectal cancerTumor markersStable tumor markerHuman colorectal cancerDistant recurrenceRecurrent cancerRecurrent tumorsPolymerase chain reactionColorectal carcinomaCodon 12TumorsArchival tissueCancerChain reactionAllele-specific amplificationPatientsRecurrenceMarkersMutationsCarcinomaDisease
1991
Squamous Cell Carcinoma of the Lung in a Nonsmoking, Nonirradiated Patient with Juvenile Laryngotracheal Papillomatosis
Guillou L, Sahli R, Chaubert P, Monnier P, Cuttat J, Costa J. Squamous Cell Carcinoma of the Lung in a Nonsmoking, Nonirradiated Patient with Juvenile Laryngotracheal Papillomatosis. The American Journal Of Surgical Pathology 1991, 15: 891-898. PMID: 1659237, DOI: 10.1097/00000478-199109000-00010.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaMalignant transformationLaryngotracheal papillomatosisJuvenile papillomatosisCell carcinomaPrevious radiation therapySquamous cell papillomasHost immune responseSpontaneous malignant transformationPeribronchial lymphPulmonary infectionSmoking historyCell papillomasImmune responsePostmortem examinationChest wallRadiation therapyViral infectionPapillomatosisCarcinomaPatientsLungInfectionMolecular studiesLymphAlveolar soft-part sarcoma of the uterine corpus: Histological, immunocytochemical and ultrastructural study of a case
Guillou L, Lamoureux E, Masse S, Costa J. Alveolar soft-part sarcoma of the uterine corpus: Histological, immunocytochemical and ultrastructural study of a case. Virchows Archiv A Pathological Anatomy And Histopathology 1991, 418: 467-471. PMID: 2035261, DOI: 10.1007/bf01605935.Peer-Reviewed Original ResearchConceptsAlveolar soft part sarcomaSoft part sarcomaUterine corpusHMB-45 antibodyEvidence of diseaseNK1/C3Hysterectomy specimenClinical managementIncidental findingDifferential diagnosisElectron microscopic examinationTumor cellsSarcomaMicroscopic examinationCytoplasmic granulesUltrastructural studyPatientsImmunoreactivityCytokeratinCrystalloidsDiseaseDiagnosisVimentinDesminAntibodies
1989
Idiopathic Entero-colic Lymphocytic Phlebitis
Saraga E, Costa J. Idiopathic Entero-colic Lymphocytic Phlebitis. The American Journal Of Surgical Pathology 1989, 13: 303-308. PMID: 2929846, DOI: 10.1097/00000478-198904000-00005.Peer-Reviewed Original ResearchConceptsLymphocytic phlebitisIntestinal ischemic necrosisSystemic vasculitisLymphocytic infiltrateClinicopathological entityIschemic necrosisSurgical specimensExtensive lesionsHistological examinationB lymphocytesLaboratory evidencePhlebitisPatientsDifferent agesVasculitisReoperationInfiltratesThrombosisArteryRecurrenceArteriolesEtiologyLesionsNecrosisMonths
1988
Interdisciplinary detection of soft tissue sarcomas. Diagnosis, grading and staging.
Leyvraz S, Costa J. Interdisciplinary detection of soft tissue sarcomas. Diagnosis, grading and staging. Die Orthopädie 1988, 17: 121-7. PMID: 3290794.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasTissue sarcomasDifferent prognostic factorsManagement of patientsStratification of patientsPrognostic factorsSimilar prognosisSurgical marginsHistological diagnosisStaging systemClinical aspectsOptimal diagnosisTumorsPatientsDiagnosisPrognosisSarcomaStagingCliniciansPathologistsGradingThe Pathological Staging of Sarcomas
Costa J, Leyvraz S. The Pathological Staging of Sarcomas. Developments In Oncology 1988, 18-21. DOI: 10.1007/978-94-009-2691-2_4.Peer-Reviewed Original Research
1987
Histopathology of bone marrow in human immunodeficiency virus infXection
Delacrétaz F, Perey L, Schmidt P, Chave J, Costa J. Histopathology of bone marrow in human immunodeficiency virus infXection. Virchows Archiv A Pathological Anatomy And Histopathology 1987, 411: 543-551. PMID: 3118563, DOI: 10.1007/bf00713285.Peer-Reviewed Original ResearchConceptsHIV infectionMyelodysplastic featuresHistological featuresHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionBone marrow findingsBone marrow biopsyMarrow findingsMarrow biopsyHaematological abnormalitiesGelatinous transformationVirus infectionHaematological findingsPatientsBone marrowConspicuous findingInfectionCell linesFindingsCytopaeniaPlasmacytosisLymphocytosisBiopsyMyelodysplasiaHypercellularityGastric Dysplasia
Saraga E, Gardiol D, Costa J. Gastric Dysplasia. The American Journal Of Surgical Pathology 1987, 11: 788-796. PMID: 3661823, DOI: 10.1097/00000478-198710000-00006.Peer-Reviewed Original Research
1986
High‐grade soft tissue sarcomas of the extremities
Potter D, Kinsella T, Glatstein E, Wesley R, White D, Seipp C, Chang A, Lack E, Costa J, Rosenberg S. High‐grade soft tissue sarcomas of the extremities. Cancer 1986, 58: 190-205. PMID: 3518911, DOI: 10.1002/1097-0142(19860701)58:1<190::aid-cncr2820580133>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH KeywordsActuarial AnalysisAdolescentAdultAgedAmputation, SurgicalAntineoplastic Combined Chemotherapy ProtocolsArmChildClinical Trials as TopicCombined Modality TherapyFemaleFollow-Up StudiesHumansLegMaleMiddle AgedNeoplasm MetastasisNeoplasm Recurrence, LocalPrognosisRandom AllocationSarcomaThighConceptsHigh-grade soft tissue sarcomasSoft tissue sarcomasNational Cancer InstituteLimb-sparing proceduresSignificant prognostic variablesOverall survivalAdjuvant chemotherapyTissue sarcomasPrognostic variablesDecreased overall survivalOutcomes of patientsDisease-free survivalMicroscopic marginsPostoperative radiotherapyFirst recurrenceProspective trialRecurrent diseaseSurgery BranchHistologic typeLocal excisionRandomized trialsPatient refusalTumor sizeCancer InstitutePatients
1984
The grading of soft tissue sarcomas results of a clinicohistopathologic correlation in a series of 163 cases
Costa J, Wesley R, Glatstein E, Rosenberg S. The grading of soft tissue sarcomas results of a clinicohistopathologic correlation in a series of 163 cases. Cancer 1984, 53: 530-541. PMID: 6692258, DOI: 10.1002/1097-0142(19840201)53:3<530::aid-cncr2820530327>3.0.co;2-d.Peer-Reviewed Original ResearchConceptsPrimary lesionOverall survivalAggressive lesionsPatient survivalBetter patient survivalSoft tissue sarcomasMinimal metastatic potentialPoor patient survivalGroup of lesionsUse of necrosisFirst recurrenceClinical courseHistologic typingHistologic featuresTissue sarcomasHistopathologic parametersStratified analysisHistologic parametersLesionsClinicohistopathologic correlationMetastatic potentialGrading systemPatientsRecurrenceNecrosis
1982
Small‐cell osteosarcoma
Martin S, Dwyer A, Kissane J, Costa J. Small‐cell osteosarcoma. Cancer 1982, 50: 990-996. PMID: 6953993, DOI: 10.1002/1097-0142(19820901)50:5<990::aid-cncr2820500529>3.0.co;2-r.Peer-Reviewed Original ResearchConceptsSmall cell osteosarcomaAdjuvant chemotherapyEwing's sarcomaEvidence of diseaseSymptoms of painForms of osteosarcomaClinical featuresOptimal therapyMonths durationRadiographic appearanceSarcomaTumorsRound cellsPatientsOsteoid matrixOsteosarcomaChemotherapyReceived radiationWide variationPainSurgeryTherapyLesionsSymptomsIncidenceHistopathological features of rapidly progressing breast carcinoma in Tunisia: A study of 94 cases
Costa J, Webber B, Levine P, Muenz L, O'Conor G, Tabbane F, Belhassen S, Kamaraju L, Mourali N. Histopathological features of rapidly progressing breast carcinoma in Tunisia: A study of 94 cases. International Journal Of Cancer 1982, 30: 35-37. PMID: 6288578, DOI: 10.1002/ijc.2910300107.Peer-Reviewed Original ResearchConceptsHistological featuresCutaneous inflammatory infiltrateNuclear grade 3Breast carcinoma patientsCases of carcinomaPercentage of casesNumber of mitosesInflammatory carcinomaCarcinoma patientsHistopathological featuresInflammatory infiltrateTumor emboliNuclear gradeRapid progressionBreast carcinomaGrade 3Clinical classificationTumor typesBreast tissueCarcinomaPatientsCutaneous permeationBreastDermisPresent studyUnusual Intranuclear Inclusions in Malignant Fibrous Histiocytoma: Presence in Primary Tumor
Tralka T, Yee C, Triche T, Costa J, Dienes H. Unusual Intranuclear Inclusions in Malignant Fibrous Histiocytoma: Presence in Primary Tumor. Ultrastructural Pathology 1982, 3: 161-167. PMID: 6285572, DOI: 10.3109/01913128209016640.Peer-Reviewed Original Research
1981
Results of Reoperation for No. 6 Persistent and Recurrent Hyperpara thyroidism
BRENNAN M, MARX S, DOPPMAN J, COSTA J, SAXE A, SPIEGEL A, KRUDY A, AURBACH G. Results of Reoperation for No. 6 Persistent and Recurrent Hyperpara thyroidism. Annals Of Surgery 1981, 194: 671-676. PMID: 7305478, PMCID: PMC1345375, DOI: 10.1097/00000658-198112000-00001.Peer-Reviewed Original ResearchConceptsFamilial hypocalciuric hypercalcemiaParathyroid carcinomaMultiple endocrine neoplasia type IMEN type IIRecurrent nerve damageResults of reoperationSingle-gland diseaseSelective venous samplingTime of dischargeHyperpara-thyroidismArteriographic examinationPredominant symptomRecurrent hyperparathyroidismNerve damageSecondary hyperplasiaVenous samplingFinal diagnosisHypocalciuric hypercalcemiaBone diseasePatientsPrevious operationsDisseminated candidiasisHyperparathyroidismHyperplasiaNational InstituteAdjuvant Chemotherapy for Patients with Soft Tissue Sarcomas
Rosenberg S, Tepper J, Glatstein E, Costa J, Young R, Seipp C, Wesley R. Adjuvant Chemotherapy for Patients with Soft Tissue Sarcomas. Surgical Clinics Of North America 1981, 61: 1415-1423. PMID: 7031940, DOI: 10.1016/s0039-6109(16)42595-8.Peer-Reviewed Original ResearchRisk of subsequent contralateral breast carcinoma in a population of patients with in‐situ breast carcinoma
Webber B, Heise H, Neifeld J, Costa J. Risk of subsequent contralateral breast carcinoma in a population of patients with in‐situ breast carcinoma. Cancer 1981, 47: 2928-2932. PMID: 6266644, DOI: 10.1002/1097-0142(19810615)47:12<2928::aid-cncr2820471232>3.0.co;2-5.Peer-Reviewed Original ResearchConceptsBreast carcinomaContralateral carcinomaSubsequent cancerContralateral breast carcinomaMajority of patientsPopulation of patientsSecond breast cancerNoninvasive breast carcinomaSitu breast carcinomaContralateral tumorsOverall survivalContralateral breastHistological typeSurvival figuresLobular carcinomaOpposite breastBreast cancerSitu carcinomaCarcinomaS. womenCancerPatientsBreastWomenMastectomy