2010
Personalized approach to prostate cancer prognosis.
Donovan M, Costa J, Cordon-Cardo C. Personalized approach to prostate cancer prognosis. Minerva Urologica E Nefrologica 2010, 62: 231-9. PMID: 20940693.Peer-Reviewed Original ResearchConceptsProstate-specific antigenProstate needle biopsyNeedle biopsyProstate cancerProstatectomy specimenDiagnostic prostate needle biopsiesSerum prostate-specific antigenPatient-specific risk profileClinical-pathologic variablesExtent of diseaseManagement of patientsAncillary diagnostic studiesTreatment decision processPrognostic featuresTumor differentiationBreast cancerIndividual patientsCancer prognosisSpecific antigenClinical judgmentHealth outcomesMost urologistsTumor typesClinical decisionPatient attributes
1993
Prognostic significance of K-ras mutations in colorectal carcinoma
Benhattar J, Losi L, Chaubert P, Givel J, Costa J. Prognostic significance of K-ras mutations in colorectal carcinoma. Gastroenterology 1993, 104: 1044-1048. PMID: 8462792, DOI: 10.1016/0016-5085(93)90272-e.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrognostic significanceColorectal carcinomaK-ras geneRecurrent diseaseCodon 12Good prognostic factorAdvanced colorectal carcinomaPossible prognostic significanceHuman colorectal carcinomaPolymerase chain reaction-based techniquesDukes' BPrognostic factorsColorectal cancerPrimary tumorOverall prevalenceHigh riskPatientsRas mutationsCarcinomaHuman tumorsTumorsDiseasePrevalenceGGT
1987
Prognostic implications of expression of the cellular genes myc, fos, Ha‐ras and Ki‐ras in colon carcinoma
Monnat M, Tardy S, Saraga P, Diggelmann H, Costa J. Prognostic implications of expression of the cellular genes myc, fos, Ha‐ras and Ki‐ras in colon carcinoma. International Journal Of Cancer 1987, 40: 293-299. PMID: 3040597, DOI: 10.1002/ijc.2910400302.Peer-Reviewed Original Research
1986
High‐grade soft tissue sarcomas of the extremities
Potter D, Kinsella T, Glatstein E, Wesley R, White D, Seipp C, Chang A, Lack E, Costa J, Rosenberg S. High‐grade soft tissue sarcomas of the extremities. Cancer 1986, 58: 190-205. PMID: 3518911, DOI: 10.1002/1097-0142(19860701)58:1<190::aid-cncr2820580133>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH KeywordsActuarial AnalysisAdolescentAdultAgedAmputation, SurgicalAntineoplastic Combined Chemotherapy ProtocolsArmChildClinical Trials as TopicCombined Modality TherapyFemaleFollow-Up StudiesHumansLegMaleMiddle AgedNeoplasm MetastasisNeoplasm Recurrence, LocalPrognosisRandom AllocationSarcomaThighConceptsHigh-grade soft tissue sarcomasSoft tissue sarcomasNational Cancer InstituteLimb-sparing proceduresSignificant prognostic variablesOverall survivalAdjuvant chemotherapyTissue sarcomasPrognostic variablesDecreased overall survivalOutcomes of patientsDisease-free survivalMicroscopic marginsPostoperative radiotherapyFirst recurrenceProspective trialRecurrent diseaseSurgery BranchHistologic typeLocal excisionRandomized trialsPatient refusalTumor sizeCancer InstitutePatients
1985
Results of multimodality therapy of resectable soft-tissue sarcomas of the retroperitoneum.
Glenn J, Sindelar W, Kinsella T, Glatstein E, Tepper J, Costa J, Baker A, Sugarbaker P, Brennan M, Seipp C. Results of multimodality therapy of resectable soft-tissue sarcomas of the retroperitoneum. Surgery 1985, 97: 316-25. PMID: 3975851.Peer-Reviewed Original ResearchConceptsRandomized studyTwo-year actuarial survival ratesSurvival rateResectable soft tissue sarcomaSevere bone marrow suppressionAggressive multimodality treatmentResectable retroperitoneal sarcomasSevere radiation enteritisActuarial survival rateBone marrow suppressionCyclophosphamide-induced cystitisSoft tissue sarcomasAdjuvant chemotherapyChemotherapy armPostoperative chemotherapyRetroperitoneal sarcomaChemotherapy regimenMajor morbidityMultimodality therapyRadiation enteritisBowel resectionMarrow suppressionMultimodality treatmentMajor complicationsCardiac toxicity
1984
The grading of soft tissue sarcomas results of a clinicohistopathologic correlation in a series of 163 cases
Costa J, Wesley R, Glatstein E, Rosenberg S. The grading of soft tissue sarcomas results of a clinicohistopathologic correlation in a series of 163 cases. Cancer 1984, 53: 530-541. PMID: 6692258, DOI: 10.1002/1097-0142(19840201)53:3<530::aid-cncr2820530327>3.0.co;2-d.Peer-Reviewed Original ResearchConceptsPrimary lesionOverall survivalAggressive lesionsPatient survivalBetter patient survivalSoft tissue sarcomasMinimal metastatic potentialPoor patient survivalGroup of lesionsUse of necrosisFirst recurrenceClinical courseHistologic typingHistologic featuresTissue sarcomasHistopathologic parametersStratified analysisHistologic parametersLesionsClinicohistopathologic correlationMetastatic potentialGrading systemPatientsRecurrenceNecrosis
1980
Advanced ovarian cancer correlation of histologic grade with response to therapy and survival
Ozols R, Garvin A, Costa J, Simon R, Young R. Advanced ovarian cancer correlation of histologic grade with response to therapy and survival. Cancer 1980, 45: 572-581. PMID: 7353206, DOI: 10.1002/1097-0142(19800201)45:3<572::aid-cncr2820450325>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsHistologic gradeStage IIIGrade 4 patientsAdvanced ovarian cancerGrade 1 patientsProspective clinical trialsSurvival of patientsChoice of chemotherapyDegree of anaplasiaDifferent survival outcomesEfficacy of chemotherapyAdvanced diseaseCombination chemotherapyProspective studySurvival outcomesCytologic gradeClinical trialsOvarian cancerStratification factorsChemotherapyPatientsGrade 2Therapeutic importanceDiseaseSurvival
1977
Prognostic Factors in Patients Undergoing Lymphadenectomy of Malignant Melanoma
COHEN A, KETCHAM A, FELIX E, LI S, tOMASZEWSKI M, COSTA J, RABSON A, SIMON R, ROSENBERG S. Prognostic Factors in Patients Undergoing Lymphadenectomy of Malignant Melanoma. Annals Of Surgery 1977, 186: 635-642. PMID: 921357, PMCID: PMC1396308, DOI: 10.1097/00000658-197711000-00016.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansLymph Node ExcisionLymph NodesLymphatic MetastasisMaleMelanomaPrognosisSkin NeoplasmsConceptsNode dissectionLevel of invasionSite of melanomaPositive nodesLymph nodesPrognostic factorsExtremity melanomaMelanoma patientsPrognostic discriminationPreoperative assessmentSame pathologistMalignant melanomaMelanoma thicknessPatientsMelanomaYears' experienceDissectionSurvivalImportant factorInvasionMultivariate evaluationAspatientsFourpatientsPrognosticfactorsThesurgeon