2017
A 49-Year-Old Man with Subacute Respiratory Failure and Interstitial Lung Opacities
Rudkovskaia AA, Lo YC, Brady V, Costa J, Fares WH. A 49-Year-Old Man with Subacute Respiratory Failure and Interstitial Lung Opacities. American Journal Of Case Reports 2017, 18: 941-944. PMID: 28855497, PMCID: PMC5590515, DOI: 10.12659/ajcr.903742.Peer-Reviewed Original ResearchConceptsPulmonary tumor thrombotic microangiopathyRight heart catheterizationPulmonary arterial hypertensionTrans-bronchial biopsyPulmonary hypertensionDiagnosis of PTTMPulseless electrical activity cardiac arrestBackground Pulmonary arterial hypertensionGastro-esophageal junction adenocarcinomaNew bilateral pulmonary infiltratesInitiation of trastuzumabMicroscopic tumor embolismSubacute respiratory failureTrans-thoracic echocardiogramTumor thrombotic microangiopathyBilateral pulmonary infiltratesSevere pulmonary hypertensionComplaints of coughRV systolic functionShortness of breathComputed tomography angiographySmall pulmonary vesselsSmooth muscle proliferationPulmonary infiltratesArterial hypertension
1999
Beta- and gamma-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer.
Caca K, Kolligs FT, Ji X, Hayes M, Qian J, Yahanda A, Rimm DL, Costa J, Fearon ER. Beta- and gamma-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer. Molecular Cancer Research 1999, 10: 369-76. PMID: 10392898.Peer-Reviewed Original ResearchMeSH KeywordsAdenomatous Polyposis Coli ProteinAmino Acid SequenceAnimalsBeta CateninCadherinsCytoskeletal ProteinsDesmoplakinsDNA-Binding ProteinsGamma CateninGene Expression Regulation, NeoplasticHMGB ProteinsHumansLymphoid Enhancer-Binding Factor 1Molecular Sequence DataMutagenesisPancreatic NeoplasmsStomach NeoplasmsTCF Transcription FactorsTrans-ActivatorsTranscription Factor 7-Like 1 ProteinTranscription FactorsTranscription, GeneticTumor Cells, CulturedConceptsPhosphorylation sitesMutant proteinsGlycogen synthase kinase 3beta phosphorylation sitesGlycogen synthase kinase-3betaFactor transcription factorsPotential phosphorylation sitesSynthase kinase-3betaTCF transcriptional activityE-cadherin inactivationNH2-terminal deletionsRole of APCImportant binding partnerSerine 28TCF transcriptionTranscriptional deregulationT-cell factorBinding partnerTranscription factorsAPC proteinKinase-3betaTranscriptional activityNH2 terminusAdenomatous polyposis coli (APC) mutationsCell adhesionPancreatic cancer lines
1987
Gastric Dysplasia
Saraga E, Gardiol D, Costa J. Gastric Dysplasia. The American Journal Of Surgical Pathology 1987, 11: 788-796. PMID: 3661823, DOI: 10.1097/00000478-198710000-00006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiopsyCarcinomaFemaleFollow-Up StudiesGastric MucosaGastroscopyHumansMaleMiddle AgedPrecancerous ConditionsStomach Neoplasms