2019
Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications
Sasaki CT, Doukas SG, Costa J, Vageli DP. Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications. Cancer 2019, 125: 3554-3565. PMID: 31310330, DOI: 10.1002/cncr.32369.Peer-Reviewed Original ResearchConceptsHuman hypopharyngeal squamous cell carcinomaAdjacent normal tissuesIL-6Reflux diseaseHypopharyngeal squamous cell carcinomaMiR-375Respective adjacent normal tissuesMiR-21Pilot studyEsophageal reflux diseaseIndependent risk factorNew clinical evidenceSquamous cell carcinomaOncomiR miR-21NF-κB activationMiR-21/miRTumor suppressor miR-375Quantitative polymerase chain reactionMessenger RNABiliary refluxHypopharyngeal carcinogenesisControl patientsLaryngopharyngeal refluxClinical evidenceHypopharyngeal carcinoma
2002
p53 Mutations as Tumor Markers in Fine Needle Aspirates of Palpable Breast Masses
Dillon DA, Hipolito E, Zheng K, Rimm DL, Costa JC. p53 Mutations as Tumor Markers in Fine Needle Aspirates of Palpable Breast Masses. Acta Cytologica 2002, 46: 841-847. PMID: 12365217, DOI: 10.1159/000327057.Peer-Reviewed Original ResearchMeSH KeywordsAbscessAdenocarcinomaAdultAgedAged, 80 and overAmino Acid SubstitutionBiomarkers, TumorBiopsy, NeedleBreast NeoplasmsCarcinoma, Ductal, BreastCodon, TerminatorCystsDNA Mutational AnalysisDNA, NeoplasmExonsFemaleFrameshift MutationGenes, p53GenotypeHumansMiddle AgedMutationPolymorphism, Single-Stranded ConformationalRetrospective StudiesConceptsFine needle aspiratesP53 exons 5Breast massesPolymerase chain reactionNeedle aspiratesP53 mutationsSingle-strand conformational polymorphism analysisSubsequent excisional biopsyPalpable breast massesPotential diagnostic utilityDefinitive cytologic diagnosisTumor cell markersExon 5Molecular diagnostic markersExcisional biopsyBenign cytologyBreast carcinomaSuspicious cytologyRetrospective analysisCytologic diagnosisTumor markersDiagnostic criteriaBiopsy tissueMorphologic diagnosisDiagnostic utility
1999
Analysis of K-ras, N-ras, H-ras, and p53 in Lung Neuroendocrine Neoplasms
Couce M, Bautista D, Costa J, Carter D. Analysis of K-ras, N-ras, H-ras, and p53 in Lung Neuroendocrine Neoplasms. Applied Immunohistochemistry & Molecular Morphology 1999, 8: 71-79. PMID: 10475381, DOI: 10.1097/00019606-199906000-00003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesDNA Mutational AnalysisExonsFemaleGenes, rasHumansImmunohistochemistryLung NeoplasmsMaleMiddle AgedMutation, MissenseNeuroendocrine TumorsPoint MutationPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Single-Stranded ConformationalRetrospective StudiesTumor Suppressor Protein p53ConceptsLarge cell neuroendocrine carcinomaPulmonary neuroendocrine tumorsAtypical carcinoidNeuroendocrine tumorsTypical carcinoidP53 geneK-rasCell neuroendocrine carcinomaSingle-strand conformation polymorphismHigh-grade tumorsHigh-grade carcinomaH-ras mutationsLung neuroendocrine neoplasmsN-rasK-ras mutationsH-RasExon 5Neuroendocrine carcinomaPolymerase chain reactionNeuroendocrine neoplasmsPositive immunostainingGenotypic mutationsN-ras geneTumors
1996
Angiotropic large cell lymphoma presenting as primary adrenal insufficiency
Chu P, Costa J, Lachman M. Angiotropic large cell lymphoma presenting as primary adrenal insufficiency. Human Pathology 1996, 27: 209-211. PMID: 8617467, DOI: 10.1016/s0046-8177(96)90379-2.Peer-Reviewed Original ResearchConceptsPrimary adrenal insufficiencyLarge cell lymphomaAdrenal insufficiencyCell lymphomaAngiotropic large cell lymphomaSevere metabolic acidosisNeoplastic lymphoid cellsB-cell lineageLymphoma PresentingUnexplained hypotensionMultiorgan involvementUnrecognized causeAdrenal glandMetabolic acidosisCortical vesselsHormone deficiencyDifferential diagnosisLymphoid cellsParenchymal cellsPatientsLymphomaInsufficiencyHypotensionCellsPresenting
1994
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
Chaubert P, Benhattar J, Saraga E, Costa J. K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis. American Journal Of Pathology 1994, 144: 767-75. PMID: 8160776, PMCID: PMC1887244.Peer-Reviewed Original ResearchConceptsK-ras mutationsLongstanding ulcerative colitisUlcerative colitisP53 alterationsActive colitisDysplastic lesionsK-rasGenetic alterationsP53 gene alterationsP53 genetic alterationsCombination of immunohistochemistryK-ras geneNonneoplastic lesionsColorectal carcinomaInvasive carcinomaColonic carcinomaDysplastic mucosaEpithelial lesionsInvasive tumorsColitisSame patientCarcinomaSporadic carcinomasLesionsNontumor samplesPapillary Variant of Low-grade Mucoepidermoid Carcinoma—An Unusual Bronchial Neoplasm: A Light Microscopic, Ultrastructural, and Immunohistochemical Study
Guillou L, De Luze P, Zysset F, Costa J. Papillary Variant of Low-grade Mucoepidermoid Carcinoma—An Unusual Bronchial Neoplasm: A Light Microscopic, Ultrastructural, and Immunohistochemical Study. American Journal Of Clinical Pathology 1994, 101: 269-274. PMID: 8135181, DOI: 10.1093/ajcp/101.3.269.Peer-Reviewed Original ResearchConceptsLow-grade mucoepidermoid carcinomaMucoepidermoid carcinomaPapillary variantLow malignant potentialBronchial mucous gland adenomaElectron microscopic featuresMucous gland adenomaAppropriate therapyLower lobePapillary tumorsMalignant potentialImmunohistochemical studyDifferential diagnosisPostmortem examinationBronchial neoplasmsGland adenomaSurface epitheliumNeoplasm categoryLight microscopicCarcinomaMicroscopic featuresLesionsTumorsLobectomyPapillomas
1993
Prognostic significance of K-ras mutations in colorectal carcinoma
Benhattar J, Losi L, Chaubert P, Givel J, Costa J. Prognostic significance of K-ras mutations in colorectal carcinoma. Gastroenterology 1993, 104: 1044-1048. PMID: 8462792, DOI: 10.1016/0016-5085(93)90272-e.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrognostic significanceColorectal carcinomaK-ras geneRecurrent diseaseCodon 12Good prognostic factorAdvanced colorectal carcinomaPossible prognostic significanceHuman colorectal carcinomaPolymerase chain reaction-based techniquesDukes' BPrognostic factorsColorectal cancerPrimary tumorOverall prevalenceHigh riskPatientsRas mutationsCarcinomaHuman tumorsTumorsDiseasePrevalenceGGT
1992
Stability of K-ras mutations throughout the natural history of human colorectal cancer
Losi L, Benhattar J, Costa J. Stability of K-ras mutations throughout the natural history of human colorectal cancer. European Journal Of Cancer 1992, 28: 1115-1120. PMID: 1627381, DOI: 10.1016/0959-8049(92)90468-h.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrimary tumorRas mutationsNatural historyColorectal cancerTumor markersStable tumor markerHuman colorectal cancerDistant recurrenceRecurrent cancerRecurrent tumorsPolymerase chain reactionColorectal carcinomaCodon 12TumorsArchival tissueCancerChain reactionAllele-specific amplificationPatientsRecurrenceMarkersMutationsCarcinomaDisease
1989
Idiopathic Entero-colic Lymphocytic Phlebitis
Saraga E, Costa J. Idiopathic Entero-colic Lymphocytic Phlebitis. The American Journal Of Surgical Pathology 1989, 13: 303-308. PMID: 2929846, DOI: 10.1097/00000478-198904000-00005.Peer-Reviewed Original ResearchConceptsLymphocytic phlebitisIntestinal ischemic necrosisSystemic vasculitisLymphocytic infiltrateClinicopathological entityIschemic necrosisSurgical specimensExtensive lesionsHistological examinationB lymphocytesLaboratory evidencePhlebitisPatientsDifferent agesVasculitisReoperationInfiltratesThrombosisArteryRecurrenceArteriolesEtiologyLesionsNecrosisMonths
1987
Gastric Dysplasia
Saraga E, Gardiol D, Costa J. Gastric Dysplasia. The American Journal Of Surgical Pathology 1987, 11: 788-796. PMID: 3661823, DOI: 10.1097/00000478-198710000-00006.Peer-Reviewed Original ResearchHistopathology of Myelodysplastic Syndromes: The FAB Classification (Proposals) Applied to Bone Marrow Biopsy
Delacrétaz F, Schmidt P, Piguet D, Bachmann F, Costa J. Histopathology of Myelodysplastic Syndromes: The FAB Classification (Proposals) Applied to Bone Marrow Biopsy. American Journal Of Clinical Pathology 1987, 87: 180-186. PMID: 3812349, DOI: 10.1093/ajcp/87.2.180.Peer-Reviewed Original ResearchConceptsBone marrow biopsyMyelodysplastic syndromeMarrow biopsyMarrow smearsType of MDSPeripheral blood blastsPercentage of blastsBone marrow aspirationBritish Cooperative GroupBlood blastsFAB classificationMarrow aspirationMonocyte countTrephine biopsyTumor infiltrationCytologic examinationPossible alternative causesFAB groupRing sideroblastsBiopsyMorphologic criteriaAlternative causesImmature precursorsAbnormal localizationCooperative groups
1986
High‐grade soft tissue sarcomas of the extremities
Potter D, Kinsella T, Glatstein E, Wesley R, White D, Seipp C, Chang A, Lack E, Costa J, Rosenberg S. High‐grade soft tissue sarcomas of the extremities. Cancer 1986, 58: 190-205. PMID: 3518911, DOI: 10.1002/1097-0142(19860701)58:1<190::aid-cncr2820580133>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH KeywordsActuarial AnalysisAdolescentAdultAgedAmputation, SurgicalAntineoplastic Combined Chemotherapy ProtocolsArmChildClinical Trials as TopicCombined Modality TherapyFemaleFollow-Up StudiesHumansLegMaleMiddle AgedNeoplasm MetastasisNeoplasm Recurrence, LocalPrognosisRandom AllocationSarcomaThighConceptsHigh-grade soft tissue sarcomasSoft tissue sarcomasNational Cancer InstituteLimb-sparing proceduresSignificant prognostic variablesOverall survivalAdjuvant chemotherapyTissue sarcomasPrognostic variablesDecreased overall survivalOutcomes of patientsDisease-free survivalMicroscopic marginsPostoperative radiotherapyFirst recurrenceProspective trialRecurrent diseaseSurgery BranchHistologic typeLocal excisionRandomized trialsPatient refusalTumor sizeCancer InstitutePatients
1985
A randomized, prospective trial of adjuvant chemotherapy in adults with soft tissue sarcomas of the head and neck, breast, and trunk
Glenn J, Kinsella T, Glatstein E, Tepper J, Baker A, Sugarbaker P, Sindelar W, Roth J, Brennan M, Costa J, Seipp C, Wesley R, Young R, Rosenberg S. A randomized, prospective trial of adjuvant chemotherapy in adults with soft tissue sarcomas of the head and neck, breast, and trunk. Cancer 1985, 55: 1206-1214. PMID: 3882217, DOI: 10.1002/1097-0142(19850315)55:6<1206::aid-cncr2820550612>3.0.co;2-e.Peer-Reviewed Original ResearchConceptsDisease-free survivalActuarial disease-free survivalOverall actuarial survivalChemotherapy armAdjuvant chemotherapyOverall survivalActuarial survivalApparent congestive heart failureAggressive local treatmentUse of chemotherapyCongestive heart failureSubgroup of patientsHigh-grade sarcomaSoft tissue sarcomasPostoperative radiotherapyProspective trialComplete resectionHeart failureAdditional patientsTreatment armsGross tumorProspective studyTissue sarcomasLocal treatmentChemotherapyResults of multimodality therapy of resectable soft-tissue sarcomas of the retroperitoneum.
Glenn J, Sindelar W, Kinsella T, Glatstein E, Tepper J, Costa J, Baker A, Sugarbaker P, Brennan M, Seipp C. Results of multimodality therapy of resectable soft-tissue sarcomas of the retroperitoneum. Surgery 1985, 97: 316-25. PMID: 3975851.Peer-Reviewed Original ResearchConceptsRandomized studyTwo-year actuarial survival ratesSurvival rateResectable soft tissue sarcomaSevere bone marrow suppressionAggressive multimodality treatmentResectable retroperitoneal sarcomasSevere radiation enteritisActuarial survival rateBone marrow suppressionCyclophosphamide-induced cystitisSoft tissue sarcomasAdjuvant chemotherapyChemotherapy armPostoperative chemotherapyRetroperitoneal sarcomaChemotherapy regimenMajor morbidityMultimodality therapyRadiation enteritisBowel resectionMarrow suppressionMultimodality treatmentMajor complicationsCardiac toxicity
1984
The grading of soft tissue sarcomas results of a clinicohistopathologic correlation in a series of 163 cases
Costa J, Wesley R, Glatstein E, Rosenberg S. The grading of soft tissue sarcomas results of a clinicohistopathologic correlation in a series of 163 cases. Cancer 1984, 53: 530-541. PMID: 6692258, DOI: 10.1002/1097-0142(19840201)53:3<530::aid-cncr2820530327>3.0.co;2-d.Peer-Reviewed Original ResearchConceptsPrimary lesionOverall survivalAggressive lesionsPatient survivalBetter patient survivalSoft tissue sarcomasMinimal metastatic potentialPoor patient survivalGroup of lesionsUse of necrosisFirst recurrenceClinical courseHistologic typingHistologic featuresTissue sarcomasHistopathologic parametersStratified analysisHistologic parametersLesionsClinicohistopathologic correlationMetastatic potentialGrading systemPatientsRecurrenceNecrosis
1982
The Treatment of Soft-tissue Sarcomas of the Extremities
ROSENBERG S, TEPPER J, GLATSTEIN E, COSTA J, BAKER A, BRENNAM M, DEMOSS E, SEIPP C, SINDELAR W, SUGARBAKER P, WESLEY R. The Treatment of Soft-tissue Sarcomas of the Extremities. Annals Of Surgery 1982, 196: 305-315. PMID: 7114936, PMCID: PMC1352604, DOI: 10.1097/00000658-198209000-00009.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasHigh-grade soft tissue sarcomasLimb-sparing groupLimb-sparing resectionLocal recurrencePostoperative chemotherapyAdult patientsTissue sarcomasRadiation therapySurvival rateDisease-free survival ratesAdjuvant radiation therapyHigh-dose methotrexateLimb-sparing surgeryOverall survival rateProspective Randomized StudyWide local excisionJoint proximalAdjuvant chemotherapyResection groupPostoperative radiotherapyOverall survivalRandomized studyLocal excisionAmputation group
1981
Results of Reoperation for No. 6 Persistent and Recurrent Hyperpara thyroidism
BRENNAN M, MARX S, DOPPMAN J, COSTA J, SAXE A, SPIEGEL A, KRUDY A, AURBACH G. Results of Reoperation for No. 6 Persistent and Recurrent Hyperpara thyroidism. Annals Of Surgery 1981, 194: 671-676. PMID: 7305478, PMCID: PMC1345375, DOI: 10.1097/00000658-198112000-00001.Peer-Reviewed Original ResearchConceptsFamilial hypocalciuric hypercalcemiaParathyroid carcinomaMultiple endocrine neoplasia type IMEN type IIRecurrent nerve damageResults of reoperationSingle-gland diseaseSelective venous samplingTime of dischargeHyperpara-thyroidismArteriographic examinationPredominant symptomRecurrent hyperparathyroidismNerve damageSecondary hyperplasiaVenous samplingFinal diagnosisHypocalciuric hypercalcemiaBone diseasePatientsPrevious operationsDisseminated candidiasisHyperparathyroidismHyperplasiaNational InstituteRisk of subsequent contralateral breast carcinoma in a population of patients with in‐situ breast carcinoma
Webber B, Heise H, Neifeld J, Costa J. Risk of subsequent contralateral breast carcinoma in a population of patients with in‐situ breast carcinoma. Cancer 1981, 47: 2928-2932. PMID: 6266644, DOI: 10.1002/1097-0142(19810615)47:12<2928::aid-cncr2820471232>3.0.co;2-5.Peer-Reviewed Original ResearchConceptsBreast carcinomaContralateral carcinomaSubsequent cancerContralateral breast carcinomaMajority of patientsPopulation of patientsSecond breast cancerNoninvasive breast carcinomaSitu breast carcinomaContralateral tumorsOverall survivalContralateral breastHistological typeSurvival figuresLobular carcinomaOpposite breastBreast cancerSitu carcinomaCarcinomaS. womenCancerPatientsBreastWomenMastectomy
1978
Osteosarcoma associated with thorotrast administration. Report of two cases and literature review
Sindelar W, Costa J, Ketcham A. Osteosarcoma associated with thorotrast administration. Report of two cases and literature review. Cancer 1978, 42: 2604-2609. PMID: 365315, DOI: 10.1002/1097-0142(197812)42:6<2604::aid-cncr2820420615>3.0.co;2-o.Peer-Reviewed Original ResearchConceptsCases of osteosarcomaPathologic evidencePrimary tumorThorotrast depositsPossible causal relationshipReticuloendothelial systemOsteosarcomaPrevious casesChronic radiationPatientsNeoplastic transformationAdministrationBoneLiterature reviewAngiographyCausal relationshipHistologyTumorsThorotrastCasesProspective randomized evaluation of the role of limb-sparing surgery, radiation therapy, and adjuvant chemoimmunotherapy in the treatment of adult soft-tissue sarcomas.
Rosenberg S, Kent H, Costa J, Webber B, Young R, Chabner B, Baker A, Brennan M, Chretien P, Cohen M, deMoss E, Sears H, Seipp C, Simon R. Prospective randomized evaluation of the role of limb-sparing surgery, radiation therapy, and adjuvant chemoimmunotherapy in the treatment of adult soft-tissue sarcomas. Surgery 1978, 84: 62-9. PMID: 663826.Peer-Reviewed Original Research