2019
Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications
Sasaki CT, Doukas SG, Costa J, Vageli DP. Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications. Cancer 2019, 125: 3554-3565. PMID: 31310330, DOI: 10.1002/cncr.32369.Peer-Reviewed Original ResearchConceptsHuman hypopharyngeal squamous cell carcinomaAdjacent normal tissuesIL-6Reflux diseaseHypopharyngeal squamous cell carcinomaMiR-375Respective adjacent normal tissuesMiR-21Pilot studyEsophageal reflux diseaseIndependent risk factorNew clinical evidenceSquamous cell carcinomaOncomiR miR-21NF-κB activationMiR-21/miRTumor suppressor miR-375Quantitative polymerase chain reactionMessenger RNABiliary refluxHypopharyngeal carcinogenesisControl patientsLaryngopharyngeal refluxClinical evidenceHypopharyngeal carcinoma
2017
A 49-Year-Old Man with Subacute Respiratory Failure and Interstitial Lung Opacities
Rudkovskaia AA, Lo YC, Brady V, Costa J, Fares WH. A 49-Year-Old Man with Subacute Respiratory Failure and Interstitial Lung Opacities. American Journal Of Case Reports 2017, 18: 941-944. PMID: 28855497, PMCID: PMC5590515, DOI: 10.12659/ajcr.903742.Peer-Reviewed Original ResearchConceptsPulmonary tumor thrombotic microangiopathyRight heart catheterizationPulmonary arterial hypertensionTrans-bronchial biopsyPulmonary hypertensionDiagnosis of PTTMPulseless electrical activity cardiac arrestBackground Pulmonary arterial hypertensionGastro-esophageal junction adenocarcinomaNew bilateral pulmonary infiltratesInitiation of trastuzumabMicroscopic tumor embolismSubacute respiratory failureTrans-thoracic echocardiogramTumor thrombotic microangiopathyBilateral pulmonary infiltratesSevere pulmonary hypertensionComplaints of coughRV systolic functionShortness of breathComputed tomography angiographySmall pulmonary vesselsSmooth muscle proliferationPulmonary infiltratesArterial hypertension
2010
Personalized approach to prostate cancer prognosis.
Donovan M, Costa J, Cordon-Cardo C. Personalized approach to prostate cancer prognosis. Minerva Urologica E Nefrologica 2010, 62: 231-9. PMID: 20940693.Peer-Reviewed Original ResearchConceptsProstate-specific antigenProstate needle biopsyNeedle biopsyProstate cancerProstatectomy specimenDiagnostic prostate needle biopsiesSerum prostate-specific antigenPatient-specific risk profileClinical-pathologic variablesExtent of diseaseManagement of patientsAncillary diagnostic studiesTreatment decision processPrognostic featuresTumor differentiationBreast cancerIndividual patientsCancer prognosisSpecific antigenClinical judgmentHealth outcomesMost urologistsTumor typesClinical decisionPatient attributes
1999
Analysis of K-ras, N-ras, H-ras, and p53 in Lung Neuroendocrine Neoplasms
Couce M, Bautista D, Costa J, Carter D. Analysis of K-ras, N-ras, H-ras, and p53 in Lung Neuroendocrine Neoplasms. Applied Immunohistochemistry & Molecular Morphology 1999, 8: 71-79. PMID: 10475381, DOI: 10.1097/00019606-199906000-00003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesDNA Mutational AnalysisExonsFemaleGenes, rasHumansImmunohistochemistryLung NeoplasmsMaleMiddle AgedMutation, MissenseNeuroendocrine TumorsPoint MutationPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Single-Stranded ConformationalRetrospective StudiesTumor Suppressor Protein p53ConceptsLarge cell neuroendocrine carcinomaPulmonary neuroendocrine tumorsAtypical carcinoidNeuroendocrine tumorsTypical carcinoidP53 geneK-rasCell neuroendocrine carcinomaSingle-strand conformation polymorphismHigh-grade tumorsHigh-grade carcinomaH-ras mutationsLung neuroendocrine neoplasmsN-rasK-ras mutationsH-RasExon 5Neuroendocrine carcinomaPolymerase chain reactionNeuroendocrine neoplasmsPositive immunostainingGenotypic mutationsN-ras geneTumors
1996
Identification of mutations in the Ki-ras gene in human retinoblastoma.
Bautista D, Emanuel J, Granville C, Howard R, Costa J. Identification of mutations in the Ki-ras gene in human retinoblastoma. Investigative Ophthalmology & Visual Science 1996, 37: 2313-7. PMID: 8843915.Peer-Reviewed Original ResearchConceptsKi-ras geneKi-rasIdentification of mutationsSelective growth advantageGenomic sequencesSingle-strand conformation polymorphismGrowth advantageTumor cell populationGenesExon 1Ki-ras mutationsMutationsExon 2Cell populationsConformation polymorphismHuman retinoblastomaClonal mutationsDirect sequencingPolymerase chain reactionTumor samplesLight microscopyMutational statusChain reactionRetinoblastomaOncogeneAngiotropic large cell lymphoma presenting as primary adrenal insufficiency
Chu P, Costa J, Lachman M. Angiotropic large cell lymphoma presenting as primary adrenal insufficiency. Human Pathology 1996, 27: 209-211. PMID: 8617467, DOI: 10.1016/s0046-8177(96)90379-2.Peer-Reviewed Original ResearchConceptsPrimary adrenal insufficiencyLarge cell lymphomaAdrenal insufficiencyCell lymphomaAngiotropic large cell lymphomaSevere metabolic acidosisNeoplastic lymphoid cellsB-cell lineageLymphoma PresentingUnexplained hypotensionMultiorgan involvementUnrecognized causeAdrenal glandMetabolic acidosisCortical vesselsHormone deficiencyDifferential diagnosisLymphoid cellsParenchymal cellsPatientsLymphomaInsufficiencyHypotensionCellsPresenting
1994
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
Chaubert P, Benhattar J, Saraga E, Costa J. K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis. American Journal Of Pathology 1994, 144: 767-75. PMID: 8160776, PMCID: PMC1887244.Peer-Reviewed Original ResearchConceptsK-ras mutationsLongstanding ulcerative colitisUlcerative colitisP53 alterationsActive colitisDysplastic lesionsK-rasGenetic alterationsP53 gene alterationsP53 genetic alterationsCombination of immunohistochemistryK-ras geneNonneoplastic lesionsColorectal carcinomaInvasive carcinomaColonic carcinomaDysplastic mucosaEpithelial lesionsInvasive tumorsColitisSame patientCarcinomaSporadic carcinomasLesionsNontumor samples
1993
Prognostic significance of K-ras mutations in colorectal carcinoma
Benhattar J, Losi L, Chaubert P, Givel J, Costa J. Prognostic significance of K-ras mutations in colorectal carcinoma. Gastroenterology 1993, 104: 1044-1048. PMID: 8462792, DOI: 10.1016/0016-5085(93)90272-e.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrognostic significanceColorectal carcinomaK-ras geneRecurrent diseaseCodon 12Good prognostic factorAdvanced colorectal carcinomaPossible prognostic significanceHuman colorectal carcinomaPolymerase chain reaction-based techniquesDukes' BPrognostic factorsColorectal cancerPrimary tumorOverall prevalenceHigh riskPatientsRas mutationsCarcinomaHuman tumorsTumorsDiseasePrevalenceGGT
1992
Stability of K-ras mutations throughout the natural history of human colorectal cancer
Losi L, Benhattar J, Costa J. Stability of K-ras mutations throughout the natural history of human colorectal cancer. European Journal Of Cancer 1992, 28: 1115-1120. PMID: 1627381, DOI: 10.1016/0959-8049(92)90468-h.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrimary tumorRas mutationsNatural historyColorectal cancerTumor markersStable tumor markerHuman colorectal cancerDistant recurrenceRecurrent cancerRecurrent tumorsPolymerase chain reactionColorectal carcinomaCodon 12TumorsArchival tissueCancerChain reactionAllele-specific amplificationPatientsRecurrenceMarkersMutationsCarcinomaDisease
1991
Squamous Cell Carcinoma of the Lung in a Nonsmoking, Nonirradiated Patient with Juvenile Laryngotracheal Papillomatosis
Guillou L, Sahli R, Chaubert P, Monnier P, Cuttat J, Costa J. Squamous Cell Carcinoma of the Lung in a Nonsmoking, Nonirradiated Patient with Juvenile Laryngotracheal Papillomatosis. The American Journal Of Surgical Pathology 1991, 15: 891-898. PMID: 1659237, DOI: 10.1097/00000478-199109000-00010.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaMalignant transformationLaryngotracheal papillomatosisJuvenile papillomatosisCell carcinomaPrevious radiation therapySquamous cell papillomasHost immune responseSpontaneous malignant transformationPeribronchial lymphPulmonary infectionSmoking historyCell papillomasImmune responsePostmortem examinationChest wallRadiation therapyViral infectionPapillomatosisCarcinomaPatientsLungInfectionMolecular studiesLymph
1989
Idiopathic Entero-colic Lymphocytic Phlebitis
Saraga E, Costa J. Idiopathic Entero-colic Lymphocytic Phlebitis. The American Journal Of Surgical Pathology 1989, 13: 303-308. PMID: 2929846, DOI: 10.1097/00000478-198904000-00005.Peer-Reviewed Original ResearchConceptsLymphocytic phlebitisIntestinal ischemic necrosisSystemic vasculitisLymphocytic infiltrateClinicopathological entityIschemic necrosisSurgical specimensExtensive lesionsHistological examinationB lymphocytesLaboratory evidencePhlebitisPatientsDifferent agesVasculitisReoperationInfiltratesThrombosisArteryRecurrenceArteriolesEtiologyLesionsNecrosisMonthsPostoperative pseudosarcomas of the genitourinary tract. A diagnostic trap. Presentation of 4 cases of which 2 were studied immunohistochemically and review of the literature.
Guillou L, Costa J. Postoperative pseudosarcomas of the genitourinary tract. A diagnostic trap. Presentation of 4 cases of which 2 were studied immunohistochemically and review of the literature. Annales De Pathologie 1989, 9: 340-5. PMID: 2692574.Peer-Reviewed Original ResearchConceptsGenitourinary tractCellular spindle cell proliferationYear old womanMetastases 8 monthsSpindle cell proliferationVaginal hysterectomyLocal excisionProstatic adenomectomyImmunohistochemical studyDiagnostic trapAppearance suggestiveNumerous mitosesTransurethral cystoscopyMuscle actinFactor VIIIMonthsStrong reactivityCell proliferationMicroscopic examinationBladderTractWomenSmooth muscle myosinNodulesAdenomectomy
1987
Histopathology of bone marrow in human immunodeficiency virus infXection
Delacrétaz F, Perey L, Schmidt P, Chave J, Costa J. Histopathology of bone marrow in human immunodeficiency virus infXection. Virchows Archiv A Pathological Anatomy And Histopathology 1987, 411: 543-551. PMID: 3118563, DOI: 10.1007/bf00713285.Peer-Reviewed Original ResearchConceptsHIV infectionMyelodysplastic featuresHistological featuresHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionBone marrow findingsBone marrow biopsyMarrow findingsMarrow biopsyHaematological abnormalitiesGelatinous transformationVirus infectionHaematological findingsPatientsBone marrowConspicuous findingInfectionCell linesFindingsCytopaeniaPlasmacytosisLymphocytosisBiopsyMyelodysplasiaHypercellularityGastric Dysplasia
Saraga E, Gardiol D, Costa J. Gastric Dysplasia. The American Journal Of Surgical Pathology 1987, 11: 788-796. PMID: 3661823, DOI: 10.1097/00000478-198710000-00006.Peer-Reviewed Original ResearchHistopathology of Myelodysplastic Syndromes: The FAB Classification (Proposals) Applied to Bone Marrow Biopsy
Delacrétaz F, Schmidt P, Piguet D, Bachmann F, Costa J. Histopathology of Myelodysplastic Syndromes: The FAB Classification (Proposals) Applied to Bone Marrow Biopsy. American Journal Of Clinical Pathology 1987, 87: 180-186. PMID: 3812349, DOI: 10.1093/ajcp/87.2.180.Peer-Reviewed Original ResearchConceptsBone marrow biopsyMyelodysplastic syndromeMarrow biopsyMarrow smearsType of MDSPeripheral blood blastsPercentage of blastsBone marrow aspirationBritish Cooperative GroupBlood blastsFAB classificationMarrow aspirationMonocyte countTrephine biopsyTumor infiltrationCytologic examinationPossible alternative causesFAB groupRing sideroblastsBiopsyMorphologic criteriaAlternative causesImmature precursorsAbnormal localizationCooperative groups
1986
High‐grade soft tissue sarcomas of the extremities
Potter D, Kinsella T, Glatstein E, Wesley R, White D, Seipp C, Chang A, Lack E, Costa J, Rosenberg S. High‐grade soft tissue sarcomas of the extremities. Cancer 1986, 58: 190-205. PMID: 3518911, DOI: 10.1002/1097-0142(19860701)58:1<190::aid-cncr2820580133>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH KeywordsActuarial AnalysisAdolescentAdultAgedAmputation, SurgicalAntineoplastic Combined Chemotherapy ProtocolsArmChildClinical Trials as TopicCombined Modality TherapyFemaleFollow-Up StudiesHumansLegMaleMiddle AgedNeoplasm MetastasisNeoplasm Recurrence, LocalPrognosisRandom AllocationSarcomaThighConceptsHigh-grade soft tissue sarcomasSoft tissue sarcomasNational Cancer InstituteLimb-sparing proceduresSignificant prognostic variablesOverall survivalAdjuvant chemotherapyTissue sarcomasPrognostic variablesDecreased overall survivalOutcomes of patientsDisease-free survivalMicroscopic marginsPostoperative radiotherapyFirst recurrenceProspective trialRecurrent diseaseSurgery BranchHistologic typeLocal excisionRandomized trialsPatient refusalTumor sizeCancer InstitutePatientsLETTERS TO THE EDITOR
Knazek R, Raphael M, Costa J. LETTERS TO THE EDITOR. Aids Research 1986, 2: 73-76. PMID: 3718617, DOI: 10.1089/aid.1.1986.2.73.Peer-Reviewed Original Research
1985
Pachydermodactyly
REICHERT C, COSTA J, BARSKY S, CLAYSMITH A, LIOTTA L, ENZINGER F, TRICHE T. Pachydermodactyly. Clinical Orthopaedics And Related Research® 1985, 194: 252-257. PMID: 3978922, DOI: 10.1097/00003086-198504000-00039.Peer-Reviewed Original ResearchConceptsReticular dermisProximal interphalangeal jointsSkin biopsy specimensYoung adult menAsymptomatic swellingInvolved sitesBiopsy specimensDense fibrosisInterphalangeal jointMarked thickeningTypical patientMedial aspectFibroblastic proliferationLateral aspectDorsal aspectPoor demarcationAdult menSubcutaneous tissuePachydermodactylyFifth digitIndex fingerCollagen type ICollagen profileCollagenous fibersDermisA randomized, prospective trial of adjuvant chemotherapy in adults with soft tissue sarcomas of the head and neck, breast, and trunk
Glenn J, Kinsella T, Glatstein E, Tepper J, Baker A, Sugarbaker P, Sindelar W, Roth J, Brennan M, Costa J, Seipp C, Wesley R, Young R, Rosenberg S. A randomized, prospective trial of adjuvant chemotherapy in adults with soft tissue sarcomas of the head and neck, breast, and trunk. Cancer 1985, 55: 1206-1214. PMID: 3882217, DOI: 10.1002/1097-0142(19850315)55:6<1206::aid-cncr2820550612>3.0.co;2-e.Peer-Reviewed Original ResearchConceptsDisease-free survivalActuarial disease-free survivalOverall actuarial survivalChemotherapy armAdjuvant chemotherapyOverall survivalActuarial survivalApparent congestive heart failureAggressive local treatmentUse of chemotherapyCongestive heart failureSubgroup of patientsHigh-grade sarcomaSoft tissue sarcomasPostoperative radiotherapyProspective trialComplete resectionHeart failureAdditional patientsTreatment armsGross tumorProspective studyTissue sarcomasLocal treatmentChemotherapyResults of multimodality therapy of resectable soft-tissue sarcomas of the retroperitoneum.
Glenn J, Sindelar W, Kinsella T, Glatstein E, Tepper J, Costa J, Baker A, Sugarbaker P, Brennan M, Seipp C. Results of multimodality therapy of resectable soft-tissue sarcomas of the retroperitoneum. Surgery 1985, 97: 316-25. PMID: 3975851.Peer-Reviewed Original ResearchConceptsRandomized studyTwo-year actuarial survival ratesSurvival rateResectable soft tissue sarcomaSevere bone marrow suppressionAggressive multimodality treatmentResectable retroperitoneal sarcomasSevere radiation enteritisActuarial survival rateBone marrow suppressionCyclophosphamide-induced cystitisSoft tissue sarcomasAdjuvant chemotherapyChemotherapy armPostoperative chemotherapyRetroperitoneal sarcomaChemotherapy regimenMajor morbidityMultimodality therapyRadiation enteritisBowel resectionMarrow suppressionMultimodality treatmentMajor complicationsCardiac toxicity