A Small-Molecule Oligosaccharyltransferase Inhibitor with Pan-flaviviral Activity
Puschnik AS, Marceau CD, Ooi YS, Majzoub K, Rinis N, Contessa JN, Carette JE. A Small-Molecule Oligosaccharyltransferase Inhibitor with Pan-flaviviral Activity. Cell Reports 2017, 21: 3032-3039. PMID: 29241533, PMCID: PMC5734657, DOI: 10.1016/j.celrep.2017.11.054.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsBenzamidesDengue VirusGene ExpressionGene Expression RegulationGenes, ReporterHEK293 CellsHexosyltransferasesHost-Pathogen InteractionsHumansLuciferasesMembrane ProteinsMicrobial Sensitivity TestsSignal TransductionSulfonamidesVirus ReplicationWest Nile virusYellow fever virusZika VirusConceptsAntiviral activityMosquito-borne flavivirusPromising antiviral activityYellow fever virusNGI-1Strong antiviral activityFlavivirus infectionImportant human pathogenAntiviral compoundsHost factorsViral RNA replicationWest NileFever virusDisease-relevant cell typesGlobal healthInfectionFlavivirusesViral mutantsBroad activityCell typesGenetic determinantsHuman pathogensRNA replicationRecent genetic screenTarget activity