2012
Caspase‐activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens
Jog NR, Frisoni L, Shi Q, Monestier M, Hernandez S, Craft J, Prak ET, Caricchio R. Caspase‐activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens. Arthritis & Rheumatism 2012, 64: 1247-1256. PMID: 22127758, PMCID: PMC3292632, DOI: 10.1002/art.33448.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAutoimmune responseMouse modelApoptotic cellsNuclear autoantigensDNA antibody titersLupus-prone miceAbsence of CADMaintenance of toleranceAutoreactive B cellsAnti-DNA antibodiesApoptotic modificationsLupus developmentGeneration of autoantigensAntinuclear antibodiesLupus erythematosusAntibody titersAutoimmune diseasesActive caspase-3Apoptotic bodiesB cellsMiceAutoantigensCAD deficiencyCaspase-3
1997
The transcriptional activator Sp1, a novel autoantigen
Spain T, Sun R, Gradzka M, Lin S, Craft J, Miller G. The transcriptional activator Sp1, a novel autoantigen. Arthritis & Rheumatism 1997, 40: 1085-1095. PMID: 9182919, DOI: 10.1002/art.1780400613.Peer-Reviewed Original ResearchConceptsTranscriptional activator Sp1Novel autoantigenComplex of DNAGC-rich sequencesActivator Sp1Undifferentiated connective tissue diseaseSp1 proteinTranscription activatorConnective tissue diseaseExtractable nuclear antigensEpstein-Barr virusSp1Nuclear extractsCellular DNAMalar rashAntinuclear antibodiesClinical characteristicsProteinDNARaynaud's phenomenonTissue diseaseAutoantigenic proteinsAutoimmune seraElectrophoretic mobilityAutoantigens
1996
Systemic autoimmunity in LGJ mice
Peng S, Madaio M, Craft J. Systemic autoimmunity in LGJ mice. Immunology Letters 1996, 53: 153-155. PMID: 9024995, DOI: 10.1016/s0165-2478(96)02616-8.Peer-Reviewed Original ResearchConceptsLG/J miceJ miceAnalysis of autoimmunityEnd-organ diseaseNon-diseased animalsAntinuclear antibodiesInterstitial nephritisLupus erythematosusRenal diseaseRheumatoid factorCutaneous diseaseSystemic autoimmunityMurine modelControl animalsJ strainJ backgroundAutoimmunityDiseaseMiceAutoantibodiesUseful modelAnimalsErythematosusPerivasculitisGlomerulonephritis
1991
PBC 95K, a 95‐kilodalton nuclear autoantigen in primary biliary cirrhosis
Evans J, Reuben A, Craft J. PBC 95K, a 95‐kilodalton nuclear autoantigen in primary biliary cirrhosis. Arthritis & Rheumatism 1991, 34: 731-736. PMID: 2053918, DOI: 10.1002/art.1780340614.Peer-Reviewed Original ResearchConceptsPrimary biliary cirrhosisAntinuclear antibodiesBiliary cirrhosisANA-positive samplesConnective tissue diseaseSera of patientsANA-positive seraHEp-2 cellsPBC patientsLiver diseaseTissue diseaseNuclear dotsPatientsIndirect immunofluorescenceNuclear autoantigensStaining patternAffinity-purified antibodiesSerumAntibodiesCirrhosisDiseaseAutoantigensTiters
1988
Murine graft vs host disease. A model for study of mechanisms that generate autoantibodies to ribonucleoproteins.
Gelpi C, Rodriguez-Sanchez JL, Martinez MA, Craft J, Hardin JA. Murine graft vs host disease. A model for study of mechanisms that generate autoantibodies to ribonucleoproteins. The Journal Of Immunology 1988, 140: 4160-6. PMID: 3372998, DOI: 10.4049/jimmunol.140.12.4160.Peer-Reviewed Original ResearchConceptsHost diseaseChronic graftAutoimmune responseMixed connective tissue diseaseInduction of graftConnective tissue diseaseHuman rheumatic diseasesAnti-U1 RNPAntinuclear antibodiesMurine graftRheumatic diseasesRNP autoantibodiesTissue diseaseAutoantigenic epitopesLymphoid cellsJ strainAdditional seraGraftDiseaseMiceSerumAntibodiesAutoantibodiesMaximal levelsHuman serum
1987
Linked sets of antinuclear antibodies: what do they mean?
Craft JE, Hardin JA. Linked sets of antinuclear antibodies: what do they mean? Journal Of Rheumatology Supplement 1987, 14 Suppl 13: 106-9. PMID: 2441041.Peer-Reviewed Original Research