2012
Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells
Kinnunen T, Chamberlain N, Morbach H, Choi J, Kim S, Craft J, Mayer L, Cancrini C, Passerini L, Bacchetta R, Ochs HD, Torgerson TR, Meffre E. Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells. Blood 2012, 121: 1595-1603. PMID: 23223361, PMCID: PMC3587322, DOI: 10.1182/blood-2012-09-457465.Peer-Reviewed Original ResearchConceptsB cell tolerancePeripheral B cell toleranceIPEX patientsRegulatory T cellsAutoreactive B cellsNaive B cellsB cellsT cellsTreg functionAutoreactive mature naive B cellsHuman B cell toleranceForkhead box protein 3 geneHuman regulatory T cellsMature naive B cellsTreg-like cellsCentral B cell toleranceSevere autoimmune disordersT-cell costimulatorTransitional B cellsRegulation of CD40LReactivity of antibodiesDefective Treg functionSingle B cellsPD-1Autoimmune disorders
2005
Role for macrophage migration inhibitory factor in asthma
Mizue Y, Ghani S, Leng L, McDonald C, Kong P, Baugh J, Lane SJ, Craft J, Nishihira J, Donnelly SC, Zhu Z, Bucala R. Role for macrophage migration inhibitory factor in asthma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 14410-14415. PMID: 16186482, PMCID: PMC1242335, DOI: 10.1073/pnas.0507189102.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAsthmaBase SequenceBronchoalveolar LavageCell ProliferationCells, CulturedCytokinesEnzyme-Linked Immunosorbent AssayFlow CytometryGene ComponentsGenotypeHumansInterleukin-5Intramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMiceMice, Inbred BALB CMice, KnockoutOvalbuminReverse Transcriptase Polymerase Chain ReactionT-Lymphocytes, Helper-InducerConceptsMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorIL-5 concentrationsLower airway hyperresponsivenessBronchoalveolar lavage fluidAntigen-specific responsesT-cell studiesWild-type miceLess pulmonary inflammationAirway hyperresponsivenessImmunologic regulatorsMIF deficiencyMIF KOMIF's roleMild asthmaWild-type controlsSevere asthmaAsthma patientsCytokine levelsMIF genotypePulmonary inflammationSpecific IgEWhite patientsAutoimmune disorders