2011
Systemic Autoimmunity and Lymphoproliferation Are Associated with Excess IL-7 and Inhibited by IL-7Rα Blockade
Gonzalez-Quintial R, Lawson BR, Scatizzi JC, Craft J, Kono DH, Baccala R, Theofilopoulos AN. Systemic Autoimmunity and Lymphoproliferation Are Associated with Excess IL-7 and Inhibited by IL-7Rα Blockade. PLOS ONE 2011, 6: e27528. PMID: 22102903, PMCID: PMC3213145, DOI: 10.1371/journal.pone.0027528.Peer-Reviewed Original ResearchConceptsT cellsIL-7Systemic autoimmunityIL-7R blockadeIL-7Rα blockadeAutoreactive T cellsMemory T cellsAdvanced disease stageProgression of autoimmunityFibroblastic reticular cellsNovel therapeutic approachesT cell activationAutoimmune manifestationsAutoimmune syndromeCommensal antigensDisease stageIL-7RαTherapeutic approachesLymphocyte homeostasisCell activationReticular cellsAutoimmunityMarked accumulationLupusBlockade
1997
Roles of interferon-gamma and interleukin-4 in murine lupus.
Peng SL, Moslehi J, Craft J. Roles of interferon-gamma and interleukin-4 in murine lupus. Journal Of Clinical Investigation 1997, 99: 1936-1946. PMID: 9109438, PMCID: PMC508018, DOI: 10.1172/jci119361.Peer-Reviewed Original ResearchConceptsEnd-organ diseaseAutoantibody productionMurine lupusIFN-gammaSerum immunoglobulinsMRL/Mp-lpr/lpr micePathogenic autoantibody productionTiters of IgG2aDevelopment of lupusSystemic autoimmune syndromeAlphabeta T cellsLess IgG1Prototypical Th1Autoimmune syndromeLpr miceProne miceTh2 cytokinesIL-4Comparable levelsTissue injuryT cellsInterleukin-4Critical cytokineLupusLymphadenopathy