2021
Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses
Cui C, Wang J, Fagerberg E, Chen PM, Connolly KA, Damo M, Cheung JF, Mao T, Askari AS, Chen S, Fitzgerald B, Foster GG, Eisenbarth SC, Zhao H, Craft J, Joshi NS. Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses. Cell 2021, 184: 6101-6118.e13. PMID: 34852236, PMCID: PMC8671355, DOI: 10.1016/j.cell.2021.11.007.Peer-Reviewed Original ResearchConceptsCD8 TB cellsTfh cellsLung adenocarcinomaTfh-B cell interactionsTumor-specific B cellsFollicular helper cellsAnti-tumor immunityB cell signaturesCell effector functionsGerminal center formationGC B cellsCD4 THelper cellsTumor controlTumor neoantigensEffector functionsCell collaborationCell responsesCell signatureTumor cellsSignature correlatesNeoantigensCell functionCD4Neoantigen driven B cell and CD4+ T follicular helper cell collaboration promotes robust anti-tumor CD8+ T cell responses
Cui C, Joshi N, Craft J. Neoantigen driven B cell and CD4+ T follicular helper cell collaboration promotes robust anti-tumor CD8+ T cell responses. The Journal Of Immunology 2021, 206: 57.01-57.01. DOI: 10.4049/jimmunol.206.supp.57.01.Peer-Reviewed Original ResearchT cell responsesAnti-tumor CD8Tfh cellsB cellsCell responsesIL-21Cell collaborationProtective anti-tumor responsesTfh-B cell interactionsTumor-specific B cellsGC B cell responsesTumor-specific CD4Anti-tumor immunityFavorable clinical outcomeAnti-tumor responseIL-21 receptorB cell responsesLung adenocarcinoma patientsAnalysis of survivalT cell-B cell interactionsGerminal center formationCell interactionsGC B cellsAbstract CD4Effector CD8
2002
Regulation of T cell-dependent autoantibody production by a γδ T cell line derived from lupus-prone mice
Fujii T, Okada M, Craft J. Regulation of T cell-dependent autoantibody production by a γδ T cell line derived from lupus-prone mice. Cellular Immunology 2002, 217: 23-35. PMID: 12425998, DOI: 10.1016/s0008-8749(02)00509-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearApoptosisB-LymphocytesCell LineCoculture TechniquesCytotoxicity Tests, ImmunologicDNAInterleukin-10Lupus Erythematosus, SystemicLymphocyte ActivationLymphocyte CooperationMiceMice, Inbred C57BLMice, Inbred MRL lprMice, KnockoutReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocytes, Helper-InducerTumor Necrosis Factor-alphaConceptsGammadelta T cell linesT cell linesAnti-dsDNA productionMRL/B cellsAutoantibody productionCell linesLupus-prone miceMRL/MpGammadelta T cellsT helper cell linesB cell collaborationActivated B cellsContact-dependent mannerAlphabeta TSevere lupusGammadelta TAutoantibody synthesisMurine lupusLupus-proneT cellsCell collaborationHelper cell lineMiceLupus