2012
IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus
Kim JS, Cho BA, Sim JH, Shah K, Woo CM, Lee EB, Lee DS, Kang JS, Lee WJ, Park CG, Craft J, Kang I, Kim HR. IL-7Rαlow memory CD8+ T cells are significantly elevated in patients with systemic lupus erythematosus. Rheumatology 2012, 51: 1587-1594. PMID: 22661557, PMCID: PMC3418646, DOI: 10.1093/rheumatology/kes100.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, BlockingAntigens, CDCD8-Positive T-LymphocytesCoculture TechniquesCytotoxicity, ImmunologicFemaleFlow CytometryHumansImmunologic MemoryImmunophenotypingLupus Erythematosus, SystemicLymphocyte CountReceptors, ImmunologicReceptors, Interleukin-7Signaling Lymphocytic Activation Molecule FamilyConceptsEffector memoryFrequency of ILT cellsHealthy individualsHuman effector memoryTarget cellsSystemic lupus erythematosusPathogenesis of lupusSLE patientsMemory CD8Lupus erythematosusNK cellsCytotoxic functionPeripheral bloodDisease manifestationsPatientsCD48 antigenCytotoxic moleculesFlow cytometrySLECell populationsPotential roleLupusILCellular characteristics
2009
Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation
Marks BR, Nowyhed HN, Choi JY, Poholek AC, Odegard JM, Flavell RA, Craft J. Thymic self-reactivity selects natural interleukin 17–producing T cells that can regulate peripheral inflammation. Nature Immunology 2009, 10: 1125-1132. PMID: 19734905, PMCID: PMC2751862, DOI: 10.1038/ni.1783.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantigensCD4-Positive T-LymphocytesCell DifferentiationEnzyme-Linked Immunosorbent AssayFlow CytometryInflammationIntegrin alpha4beta1Interleukin-17Interleukin-23Interleukin-6InterleukinsMiceMice, TransgenicNuclear Receptor Subfamily 1, Group F, Member 3Polymerase Chain ReactionReceptors, CCR6Receptors, Retinoic AcidReceptors, Thyroid HormoneThymus GlandT-Lymphocyte SubsetsTransforming Growth Factor beta