2011
IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis
Tao J, Kamanaka M, Hao J, Hao Z, Jiang X, Craft JE, Flavell RA, Wu Z, Hong Z, Zhao L, Yin Z. IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis. Arthritis Research & Therapy 2011, 13: r212. PMID: 22192790, PMCID: PMC3334665, DOI: 10.1186/ar3545.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArthritis, ExperimentalCattleCD4-Positive T-LymphocytesCell ProliferationCollagen Type IIFemaleFlow CytometryForkhead Transcription FactorsInterferon-gammaInterleukin-10Interleukin-17Lymphocyte ActivationMaleMiceMice, Inbred C57BLMice, Inbred DBAMice, TransgenicReceptors, Antigen, T-Cell, gamma-deltaReceptors, Interleukin-10Reverse Transcriptase Polymerase Chain ReactionSignal TransductionT-Lymphocytes, RegulatoryConceptsCollagen-induced arthritisIL-10 signalingIL-17 mRNARegulatory T cellsT cell proliferationT cellsT cell activationSuppressive functionImportant anti-inflammatory cytokineBovine type II collagenAnti-inflammatory cytokinesFunction of TregsAbility of TregsSeverity of arthritisLevels of Foxp3Wild-type miceAntigen-specific antibodiesUnpaired t-testMore IFNControl miceCytokine productionTg miceInflammatory jointsFemale miceArthritic joints
2007
CNS lupus in MRL/Faslpr mice (130.15)
Choi J, Chahboune H, Hyder F, Craft J. CNS lupus in MRL/Faslpr mice (130.15). The Journal Of Immunology 2007, 178: s230-s230. DOI: 10.4049/jimmunol.178.supp.130.15.Peer-Reviewed Original ResearchMRL/Faslpr miceFaslpr miceDiffusion tensor imagingControl miceStructural abnormalitiesCentral nervous system injurySpontaneous autoimmune diseaseLupus-prone miceNervous system injuryToll-like receptorsWeeks of ageCNS lupusIg depositionNeurological deficitsHuman SLENeuropsychiatric involvementSystem injuryAntibody depositionAutoimmune diseasesDTI alterationsMRL miceChoroid plexusMiceTensor imagingHippocampus
2005
Naive CD4+ T Cells from Lupus-Prone Fas-Intact MRL Mice Display TCR-Mediated Hyperproliferation Due to Intrinsic Threshold Defects in Activation
Zielinski CE, Jacob SN, Bouzahzah F, Ehrlich BE, Craft J. Naive CD4+ T Cells from Lupus-Prone Fas-Intact MRL Mice Display TCR-Mediated Hyperproliferation Due to Intrinsic Threshold Defects in Activation. The Journal Of Immunology 2005, 174: 5100-5109. PMID: 15814741, DOI: 10.4049/jimmunol.174.8.5100.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutoimmunityCalcium SignalingCD4-Positive T-LymphocytesCell ProliferationColumbidaeCytochromes cDendritic CellsFas ReceptorGenes, DominantInterleukin-2Lupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred MRL lprMice, Inbred StrainsMice, KnockoutMice, TransgenicPhenotypeReceptor-CD3 Complex, Antigen, T-CellReceptors, Antigen, T-CellSignal TransductionConceptsNaive CD4T cellsSelf-AgAutoreactive T cell activationMRL T cellsT cell toleranceF1 T cellsProximal defectsAnti-CD3 stimulationClass II MHCIL-2 productionT cell activationWild-type CD4Pigeon cytochrome cCell calcium signalingDendritic cellsControl miceMurine lupusObserved hyperactivityII MHCMRL miceIntracellular calciumLow thresholdPeptide AgCD4
1996
Protective antibodies in murine Lyme disease arise independently of CD40 ligand.
Fikrig E, Barthold SW, Chen M, Grewal IS, Craft J, Flavell RA. Protective antibodies in murine Lyme disease arise independently of CD40 ligand. The Journal Of Immunology 1996, 157: 1-3. PMID: 8683101, DOI: 10.4049/jimmunol.157.1.1.Peer-Reviewed Original ResearchConceptsCD40L-deficient miceCD40 ligand-deficient miceMurine Lyme diseaseRegression of arthritisTransfer of serumDependent immune responsesIgG2b AbsAcute arthritisControl miceProtective antibodiesIg class switchingCD40 ligandImmune responseImmunodeficient miceLyme borreliosisLyme diseaseMiceBorrelia burgdorferiB. burgdorferiClass switchingArthritisBurgdorferiAbInfectionDisease