2013
Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice
Look M, Stern E, Wang QA, DiPlacido LD, Kashgarian M, Craft J, Fahmy TM. Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice. Journal Of Clinical Investigation 2013, 123: 1741-1749. PMID: 23454752, PMCID: PMC3613921, DOI: 10.1172/jci65907.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusMedian survival timeMycophenolic acidLupus erythematosusImmune cellsLupus-prone NZB/W F1 miceNZB/W F1 miceSimilar therapeutic resultsW F1 miceSevere renal damageCD4 T cellsAntigen-presenting cellsLupus therapyRenal damageIL-12Immunosuppressant mycophenolic acidInflammatory cytokinesProphylactic useTherapeutic resultsF1 miceT cellsSurvival timeGreater dosesErythematosusImmunosuppression
2012
The pathogenesis of systemic lupus erythematosus—an update
Choi J, Kim ST, Craft J. The pathogenesis of systemic lupus erythematosus—an update. Current Opinion In Immunology 2012, 24: 651-657. PMID: 23131610, PMCID: PMC3508331, DOI: 10.1016/j.coi.2012.10.004.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus erythematosusAberrant adaptive immune responseAdaptive immune responsesDisease-specific therapeutic targetsInnate immune mechanismsPathogenic autoantibodiesImmune mechanismsTissue injuryImmune responseTherapeutic targetB cellsDisease mechanismsErythematosusClinical biologyRecent studiesAutoantibodiesLupusSLEPathogenesisInjuryFollicular helper T cells in immunity and systemic autoimmunity
Craft JE. Follicular helper T cells in immunity and systemic autoimmunity. Nature Reviews Rheumatology 2012, 8: 337-347. PMID: 22549246, PMCID: PMC3604997, DOI: 10.1038/nrrheum.2012.58.Peer-Reviewed Original ResearchConceptsFollicular helper T cellsHelper T cellsT cellsSelf-reactive B cell clonesT helper cell populationSystemic lupus erythematosusSystemic autoimmune diseaseNormal immune responseT cell helpB cell clonesB cell survivalLupus erythematosusAutoantibody productionAutoimmune diseasesSystemic autoimmunityImmune responseAutoimmunityKey regulatorErythematosusCellsDiseaseImmunity
2011
Dissecting the Immune Cell Mayhem That Drives Lupus Pathogenesis
Craft JE. Dissecting the Immune Cell Mayhem That Drives Lupus Pathogenesis. Science Translational Medicine 2011, 3: 73ps9. PMID: 21389262, PMCID: PMC3694130, DOI: 10.1126/scitranslmed.3002138.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusPathogenesis of SLEAutoimmune disease systemic lupus erythematosusDisease systemic lupus erythematosusSerious side effectsScience Translational MedicineLupus pathogenesisLupus erythematosusImmunosuppressive drugsCombination therapyCommon treatmentSide effectsImmune systemPathogenesisTherapyTranslational medicineErythematosusInflammationInterferonNeutrophils
2008
Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease
KRATZ A, HARDING MW, CRAFT J, MACKWORTH-YOUNG C, HANDSCHUMACHER RE. Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease. Clinical & Experimental Immunology 2008, 90: 422-427. PMID: 1458678, PMCID: PMC1554566, DOI: 10.1111/j.1365-2249.1992.tb05862.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAmino Acid IsomerasesAntibodies, Anti-IdiotypicAntibodies, MonoclonalAntibody SpecificityAutoantibodiesCarrier ProteinsChildEnzyme-Linked Immunosorbent AssayFamily HealthFemaleHumansImmunoglobulin GImmunoglobulin IdiotypesImmunoglobulin MLupus Erythematosus, SystemicLyme DiseaseMaleMiddle AgedPeptidylprolyl IsomeraseProtein DenaturationConceptsSystemic lupus erythematosusLupus erythematosusFirst-degree relativesLyme disease patientsMonoclonal IgM antibodyLupus patientsIgM antibodiesDisease patientsLepromatous leprosyImmune systemPatientsWestern blotLyme diseaseAntibodiesErythematosusAutoantibodiesHypergammaglobulinaemiaCyclophilinCyclosporinLeprosyDiseaseSerum
2003
Enhanced proliferative response of CD4+ T cells from patients with systemic lupus erythematosus by T-cell receptor stimulation
Park S, Kang I, Kim H, Craft J. Enhanced proliferative response of CD4+ T cells from patients with systemic lupus erythematosus by T-cell receptor stimulation. Arthritis Research & Therapy 2003, 5: 151. PMCID: PMC2833942, DOI: 10.1186/ar952.Peer-Reviewed Original ResearchIntrinsic T Cell Defects in Systemic Autoimmunity
KONG PL, ODEGARD JM, BOUZAHZAH F, CHOI J, EARDLEY LD, ZIELINSKI CE, CRAFT JE. Intrinsic T Cell Defects in Systemic Autoimmunity. Annals Of The New York Academy Of Sciences 2003, 987: 60-67. PMID: 12727624, DOI: 10.1111/j.1749-6632.2003.tb06033.x.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusT cell defectsIntrinsic T cell defectCell defectsT cell toleranceLupus pathogenesisLupus erythematosusAutoimmune diseasesSystemic autoimmunityT cellsCell toleranceNuclear antigenGenetic causeLupusBiochemical natureErythematosusAutoimmunityPathogenesisAntigenDiseaseMice
2001
From T to B and back again: positive feedback in systemic autoimmune disease
Shlomchik M, Craft J, Mamula M. From T to B and back again: positive feedback in systemic autoimmune disease. Nature Reviews Immunology 2001, 1: 147-153. PMID: 11905822, DOI: 10.1038/35100573.Peer-Reviewed Original ResearchConceptsSystemic autoimmune diseaseAutoimmune diseasesPrototypical systemic autoimmune diseaseSystemic lupus erythematosusPerpetuation of autoimmunityLoss of toleranceAutoantigen targetsLupus erythematosusAutoimmune stateB cellsImmune systemNuclear autoantigensDiseaseErythematosusAutoimmunityAutoantigens
1997
Revisiting autoantibody profiles in systemic lupus erythematosus.
Olhoffer IH, Peng SL, Craft J. Revisiting autoantibody profiles in systemic lupus erythematosus. The Journal Of Rheumatology 1997, 24: 297-302. PMID: 9034986.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusImmune dysregulationLupus erythematosusAutoantibody profileAutoimmune responseAutoantibody specificitiesU1-RNPGlobal immune dysregulationAutoantibody-positive patientsSoluble autoantigensUbiquitous autoantigensPositive patientsIndividual patientsRetrospective analysisPatientsErythematosusAutoantibodiesAutoantigensDysregulationSpecificityBroad spectrumAutoimmunityDefinitive assayPrevalence
1996
Systemic autoimmunity in LGJ mice
Peng S, Madaio M, Craft J. Systemic autoimmunity in LGJ mice. Immunology Letters 1996, 53: 153-155. PMID: 9024995, DOI: 10.1016/s0165-2478(96)02616-8.Peer-Reviewed Original ResearchConceptsLG/J miceJ miceAnalysis of autoimmunityEnd-organ diseaseNon-diseased animalsAntinuclear antibodiesInterstitial nephritisLupus erythematosusRenal diseaseRheumatoid factorCutaneous diseaseSystemic autoimmunityMurine modelControl animalsJ strainJ backgroundAutoimmunityDiseaseMiceAutoantibodiesUseful modelAnimalsErythematosusPerivasculitisGlomerulonephritisMurine lupus in the absence of alpha beta T cells.
Peng SL, Madaio MP, Hughes DP, Crispe IN, Owen MJ, Wen L, Hayday AC, Craft J. Murine lupus in the absence of alpha beta T cells. The Journal Of Immunology 1996, 156: 4041-9. PMID: 8621947, DOI: 10.4049/jimmunol.156.10.4041.Peer-Reviewed Original ResearchConceptsAlpha beta T cellsT cell-dependent mechanismBeta T cellsCell-dependent mechanismT cellsMurine lupusHuman systemic lupus erythematosusLupus-prone MRL miceSystemic lupus erythematosusSystemic autoimmune diseaseLupus erythematosusAutoimmune diseasesImmune depositsMRL miceAlpha betaLupusDiseaseMiceCellsErythematosusHypergammaglobulinemiaAutoantibodiesCD4AutoimmunityKidneySpliceosomal snRNPs Autoantibodies
Peng S, Craft J. Spliceosomal snRNPs Autoantibodies. 1996, 774-782. DOI: 10.1016/b978-044482383-0/50119-9.Peer-Reviewed Original ResearchConnective tissue diseaseAntinuclear antibody testAnti-snRNP antibodiesTissue diseaseSystemic lupus erythematosusImmunofluorescent antinuclear antibody testAnti-Sm specificityLupus erythematosusClinical presentationRheumatological diseasesAutoantibodiesAntibody testDiseaseRNA epitopeAntibodiesSpecificityErythematosusIntensive efforts
1994
Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells
Wen L, Roberts S, Viney J, Wong F, Mallick C, Findly R, Peng Q, Craft J, Owen M, Mayday A. Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells. Nature 1994, 369: 654-658. PMID: 8208291, DOI: 10.1038/369654a0.Peer-Reviewed Original ResearchConceptsΑβ T cellsT cellsT cell antigen receptorB cell-T cell interactionsHelp of CD4Provision of cytokinesB cell hyperactivitySystemic lupus erythematosusCognate B cell-T cell interactionT cell functionGeneralized autoimmunityLupus erythematosusTransplant rejectionIgE secretionImmunoglobulin synthesisB cellsIgG3 secretionAntigen receptorCD4AutoimmunityMiceSecretionAntibodiesCellsErythematosus
1993
Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles.
Fatenejad S, Mamula MJ, Craft J. Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 12010-12014. PMID: 8265662, PMCID: PMC48115, DOI: 10.1073/pnas.90.24.12010.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAutoreactive T cellsLupus erythematosusT cellsAutoantibody productionSuch miceAutoreactive helper T cellsHelper T-cell determinantsHelper T cellsT cell determinantsAutoantibody responseAutoimmune responseAntibody responseNormal miceImmune responseB cellsAutoantibodiesErythematosusMiceCentral targetPatientsImmunizationSnRNP particlesCellsMolecular mimics
1992
ANTIBODIES TO snRNPs IN SYSTEMIC LUPUS ERYTHEMATOSUS
Craft J. ANTIBODIES TO snRNPs IN SYSTEMIC LUPUS ERYTHEMATOSUS. Rheumatic Disease Clinics Of North America 1992, 18: 311-335. PMID: 1626072, DOI: 10.1016/s0889-857x(21)00730-4.Peer-Reviewed Original Research
1989
Biochemical and immunological heterogeneity of the Ro ribonucleoprotein particles. Analysis with sera specific for the RohY5 particle.
Boire G, Craft J. Biochemical and immunological heterogeneity of the Ro ribonucleoprotein particles. Analysis with sera specific for the RohY5 particle. Journal Of Clinical Investigation 1989, 84: 270-279. PMID: 2472427, PMCID: PMC303979, DOI: 10.1172/jci114150.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusRelated diseasesRo particleAnti-Ro autoantibodiesAnti-Ro seraCell fractionRo antibodiesSystemic lupusLupus erythematosusPatient seraImmunological heterogeneityAutoantibodiesSpecific serumRo responseNonhuman cell linesSerumAntigenic determinantsAntibodiesCell linesInhibition assaysDiseaseEpitopesCompetitive inhibitionSuch extractsErythematosus
1988
Antibodies in human serum that precipitate ribonuclease P.
Gold HA, Craft J, Hardin JA, Bartkiewicz M, Altman S. Antibodies in human serum that precipitate ribonuclease P. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 5483-5487. PMID: 2456570, PMCID: PMC281781, DOI: 10.1073/pnas.85.15.5483.Peer-Reviewed Original ResearchThe U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes.
Craft J, Mimori T, Olsen TL, Hardin JA. The U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes. Journal Of Clinical Investigation 1988, 81: 1716-1724. PMID: 2968364, PMCID: PMC442616, DOI: 10.1172/jci113511.Peer-Reviewed Original Research
1987
Autoantigenic histone epitopes: a comparison between procainamide‐ and hydralazine‐induced lupus
Craft J, Radding J, Harding M, Bernstein R, Hardin J. Autoantigenic histone epitopes: a comparison between procainamide‐ and hydralazine‐induced lupus. Arthritis & Rheumatism 1987, 30: 689-694. PMID: 2440452, DOI: 10.1002/art.1780300612.Peer-Reviewed Original ResearchConceptsHydralazine-induced lupusSpontaneous systemic lupus erythematosusDrug-induced lupusSystemic lupus erythematosusAbility of serumProcainamide-induced lupusHistone epitopesLupus erythematosusAntihistone antibodiesLupusTechnique of immunoblottingPatientsIndividual histonesSerumEpitopesHistone fragmentsDifferent mechanismsErythematosusProcainamideAntibodiesLinked sets of antinuclear antibodies: what do they mean?
Craft JE, Hardin JA. Linked sets of antinuclear antibodies: what do they mean? Journal Of Rheumatology Supplement 1987, 14 Suppl 13: 106-9. PMID: 2441041.Peer-Reviewed Original Research