1996
Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells.
Wen L, Pao W, Wong FS, Peng Q, Craft J, Zheng B, Kelsoe G, Dianda L, Owen MJ, Hayday AC. Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. Journal Of Experimental Medicine 1996, 183: 2271-2282. PMID: 8642336, PMCID: PMC2192585, DOI: 10.1084/jem.183.5.2271.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesClone CellsFlow CytometryGerminal CenterHumansImmunoglobulin Class SwitchingImmunoglobulin EImmunoglobulin GLupus Erythematosus, SystemicLymphocyte DepletionMiceMice, Inbred NODMice, Inbred StrainsMice, KnockoutMice, SCIDReceptors, Antigen, T-Cell, alpha-betaSpleenT-LymphocytesConceptsSystemic lupus erythematosusBeta T cellsAlpha/beta T cellsGamma/delta T cellsDelta T cellsT cell helpT cellsT cell receptorCell helpT cell-mediated conditionsHuman systemic lupus erythematosusSevere combined immunodeficient (SCID) miceDevelopment of autoantibodiesCombined Immunodeficient MiceT-cell immunodeficiencyClass-switched antibodiesB cell collaborationGerminal center formationLupus erythematosusAutoantibody productionLymphoid folliclesImmunoglobulin class switchingIgE synthesisAlpha/betaCell immunodeficiency
1995
T cells with gamma/delta T cell receptors (TCR) of intestinal type are preferentially expanded in TCR-alpha-deficient lpr mice.
Hughes DP, Hayday A, Craft JE, Owen MJ, Crispe IN. T cells with gamma/delta T cell receptors (TCR) of intestinal type are preferentially expanded in TCR-alpha-deficient lpr mice. Journal Of Experimental Medicine 1995, 182: 233-241. PMID: 7540652, PMCID: PMC2192080, DOI: 10.1084/jem.182.1.233.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceApoptosisBase SequenceCell DivisionCell MovementDNA Transposable ElementsFas ReceptorImmunophenotypingIntestinal MucosaLymph NodesLymphocyte CountLymphoproliferative DisordersMiceMice, KnockoutMice, Mutant StrainsMolecular Sequence DataReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSpecific Pathogen-Free OrganismsT-Lymphocyte SubsetsConceptsLpr/lpr miceT cell receptorIntestinal intraepithelial lymphocytesLpr miceT cellsIntraepithelial lymphocytesAlpha/beta T cellsGamma/delta T cell receptorGamma/delta T cellsLymph node cell numberTCR gamma/deltaDelta T-cell receptorFas-deficient lpr micePeripheral lymphoid systemT-cell contributionPeripheral lymph nodesBeta T cellsDelta T cellsActivation-induced cell deathGene-ablated miceRole of FasT cell developmentLymph nodesIntestinal typeLymphoid system