1984
The antibody response in Lyme disease.
Craft JE, Grodzicki RL, Shrestha M, Fischer DK, García-Blanco M, Steere AC. The antibody response in Lyme disease. The Yale Journal Of Biology And Medicine 1984, 57: 561-5. PMID: 6393607, PMCID: PMC2590019.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayHumoral immune responseAntibody responseImmune responseIndirect immunofluorescenceLyme diseaseI. dammini spirocheteLyme arthritis patientsSpecific IgG responseSpecific IgM responseMonths of remissionSpecific IgM levelsIxodes dammini spirocheteLyme disease seraCross-reactive antibodiesTotal serum IgM.Lyme disease patientsAbsorption of seraArthritis patientsLyme arthritisIgG responsesIgM responseIgM levelsSpirochetal antigensDisease patients
1983
The early clinical manifestations of Lyme disease.
Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman JH, Rahn DW, Sigal LH, Spieler PN, Stenn KS, Malawista SE. The early clinical manifestations of Lyme disease. Annals Of Internal Medicine 1983, 99: 76-82. PMID: 6859726, DOI: 10.7326/0003-4819-99-1-76.Peer-Reviewed Original ResearchConceptsLyme diseaseSkin lesionsElevated serum IgM levelsMigratory musculoskeletal painTick-transmitted spirochetesUnique skin lesionAspartate transaminase levelsEarly clinical manifestationsEarly Lyme diseaseSerum IgM levelsErythema chronicum migransMeningeal irritationLaboratory abnormalitiesNonproductive coughTransaminase levelsUrticarial rashMusculoskeletal painRegional lymphadenopathySkin manifestationsSore throatDermatologic manifestationsSerologic testingClinical manifestationsIgM levelsPeriorbital edema