2023
T follicular helper cells in cancer, tertiary lymphoid structures, and beyond
Cui C, Craft J, Joshi N. T follicular helper cells in cancer, tertiary lymphoid structures, and beyond. Seminars In Immunology 2023, 69: 101797. PMID: 37343412, DOI: 10.1016/j.smim.2023.101797.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTumor-associated tertiary lymphoid structuresFollicular helper cellsCD8 T cellsTertiary lymphoid structuresSecondary lymphoid organsT cellsHelper cellsLymphoid structuresImmune cellsB cellsCD4 T follicular helper cellsT Follicular Helper CellsTumor-infiltrating immune cellsCurrent immunotherapy regimensCheckpoint blockade immunotherapyCD4 T cellsImmune cell componentsLimited response rateFunctional immune cellsNovel therapeutic targetPotential therapeutic benefitT cell-B cell interactionsBlockade immunotherapyImmunotherapy regimensLymphoid organs
2020
Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis
Chen PM, Wilson PC, Shyer JA, Veselits M, Steach HR, Cui C, Moeckel G, Clark MR, Craft J. Kidney tissue hypoxia dictates T cell–mediated injury in murine lupus nephritis. Science Translational Medicine 2020, 12 PMID: 32269165, PMCID: PMC8055156, DOI: 10.1126/scitranslmed.aay1620.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factor-1Lupus nephritisT cellsTissue hypoxiaT-cell-mediated injuryCell-mediated injuryHIF-1 blockadeKidney tissue hypoxiaSystemic lupus erythematosusHuman lupus nephritisMurine lupus nephritisRenal injuryAutoimmune injuryLupus erythematosusAutoimmune diseasesImmune cellsRenal tissueMurine modelTissue damageMore hypoxicNephritisInjuryLow oxygen tensionOxygen tensionFactor 1
2016
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
Chan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, Burchard EG, Torgerson DG, Ghosh S, Rothlin CV. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science 2016, 352: 99-103. PMID: 27034374, PMCID: PMC4935984, DOI: 10.1126/science.aaf1358.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsAsthmaBlood ProteinsDendritic CellsDisease Models, AnimalGene Knockout TechniquesHost-Parasite InteractionsHumansImmunity, InnateInterleukin-4MiceMice, Inbred C57BLMice, KnockoutNippostrongylusProtein SPyroglyphidaeReceptor Protein-Tyrosine KinasesStrongylida InfectionsT-LymphocytesConceptsType 2 immunityType 2 responsesType 2 cytokinesHuman dendritic cellsInnate immune cellsDendritic cellsAllergic diseasesImmune cellsT cellsAdaptive immunityInterleukin-4Host responseFunctional neutralizationGenetic ablationReceptor tyrosine kinasesImmunityProtective functionTyro3Tyrosine kinaseNegative regulatorPROS1CellsResponseCytokinesDisease
2013
Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice
Look M, Stern E, Wang QA, DiPlacido LD, Kashgarian M, Craft J, Fahmy TM. Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice. Journal Of Clinical Investigation 2013, 123: 1741-1749. PMID: 23454752, PMCID: PMC3613921, DOI: 10.1172/jci65907.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusMedian survival timeMycophenolic acidLupus erythematosusImmune cellsLupus-prone NZB/W F1 miceNZB/W F1 miceSimilar therapeutic resultsW F1 miceSevere renal damageCD4 T cellsAntigen-presenting cellsLupus therapyRenal damageIL-12Immunosuppressant mycophenolic acidInflammatory cytokinesProphylactic useTherapeutic resultsF1 miceT cellsSurvival timeGreater dosesErythematosusImmunosuppression
2010
Epstein‐Barr virus promotes interferon‐α production by plasmacytoid dendritic cells
Quan TE, Roman RM, Rudenga BJ, Holers VM, Craft JE. Epstein‐Barr virus promotes interferon‐α production by plasmacytoid dendritic cells. Arthritis & Rheumatism 2010, 62: 1693-1701. PMID: 20178121, PMCID: PMC2885535, DOI: 10.1002/art.27408.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, NuclearDendritic CellsDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFlow CytometryHerpesvirus 4, HumanHumansImmunity, HumoralInterferon-alphaLupus Erythematosus, SystemicMajor Histocompatibility ComplexStatistics, NonparametricToll-Like Receptor 7Toll-Like Receptor 9ConceptsPlasmacytoid dendritic cellsSystemic lupus erythematosusHuman plasmacytoid dendritic cellsIFNalpha productionDendritic cellsEpstein-Barr virus infectionToll-like receptor 9Interferon-alpha levelsPresence of EBVChronic viral infectionsElevated viral loadAbility of EBVInnate immune cellsEpstein-Barr virusMajor histocompatibility complex moleculesInnate immune responseEnzyme-linked immunosorbent assayHistocompatibility complex moleculesSLE patientsEBV DNATLR-7Lupus erythematosusViral loadReceptor 9Immune cells
2006
CHAPTER 28 Systemic Lupus Erythematosus: Immunologic Features
KANG I, CRAFT J. CHAPTER 28 Systemic Lupus Erythematosus: Immunologic Features. 2006, 357-367. DOI: 10.1016/b978-012595961-2/50031-7.Peer-Reviewed Original ResearchSystemic lupus erythematosusPlasmacytoid dendritic cellsT cellsAdaptive immunityImmune complexesAberrant innate immune responsesAdaptive immune cellsUpregulation of IFNSubsequent tissue injuryPeripheral blood cellsInnate immune responseActivation of complementRespective autoantigensDendritic cellsLupus erythematosusData support rolesImmune cellsSerologic hallmarkTissue injuryClinical diseaseImmune responseTarget organsFc receptorsB cellsImmune system