2011
Dissecting the Immune Cell Mayhem That Drives Lupus Pathogenesis
Craft JE. Dissecting the Immune Cell Mayhem That Drives Lupus Pathogenesis. Science Translational Medicine 2011, 3: 73ps9. PMID: 21389262, PMCID: PMC3694130, DOI: 10.1126/scitranslmed.3002138.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusPathogenesis of SLEAutoimmune disease systemic lupus erythematosusDisease systemic lupus erythematosusSerious side effectsScience Translational MedicineLupus pathogenesisLupus erythematosusImmunosuppressive drugsCombination therapyCommon treatmentSide effectsImmune systemPathogenesisTherapyTranslational medicineErythematosusInflammationInterferonNeutrophils
2008
Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease
KRATZ A, HARDING MW, CRAFT J, MACKWORTH-YOUNG C, HANDSCHUMACHER RE. Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease. Clinical & Experimental Immunology 2008, 90: 422-427. PMID: 1458678, PMCID: PMC1554566, DOI: 10.1111/j.1365-2249.1992.tb05862.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAmino Acid IsomerasesAntibodies, Anti-IdiotypicAntibodies, MonoclonalAntibody SpecificityAutoantibodiesCarrier ProteinsChildEnzyme-Linked Immunosorbent AssayFamily HealthFemaleHumansImmunoglobulin GImmunoglobulin IdiotypesImmunoglobulin MLupus Erythematosus, SystemicLyme DiseaseMaleMiddle AgedPeptidylprolyl IsomeraseProtein DenaturationConceptsSystemic lupus erythematosusLupus erythematosusFirst-degree relativesLyme disease patientsMonoclonal IgM antibodyLupus patientsIgM antibodiesDisease patientsLepromatous leprosyImmune systemPatientsWestern blotLyme diseaseAntibodiesErythematosusAutoantibodiesHypergammaglobulinaemiaCyclophilinCyclosporinLeprosyDiseaseSerum
2006
CHAPTER 28 Systemic Lupus Erythematosus: Immunologic Features
KANG I, CRAFT J. CHAPTER 28 Systemic Lupus Erythematosus: Immunologic Features. 2006, 357-367. DOI: 10.1016/b978-012595961-2/50031-7.Peer-Reviewed Original ResearchSystemic lupus erythematosusPlasmacytoid dendritic cellsT cellsAdaptive immunityImmune complexesAberrant innate immune responsesAdaptive immune cellsUpregulation of IFNSubsequent tissue injuryPeripheral blood cellsInnate immune responseActivation of complementRespective autoantigensDendritic cellsLupus erythematosusData support rolesImmune cellsSerologic hallmarkTissue injuryClinical diseaseImmune responseTarget organsFc receptorsB cellsImmune system
2001
From T to B and back again: positive feedback in systemic autoimmune disease
Shlomchik M, Craft J, Mamula M. From T to B and back again: positive feedback in systemic autoimmune disease. Nature Reviews Immunology 2001, 1: 147-153. PMID: 11905822, DOI: 10.1038/35100573.Peer-Reviewed Original ResearchConceptsSystemic autoimmune diseaseAutoimmune diseasesPrototypical systemic autoimmune diseaseSystemic lupus erythematosusPerpetuation of autoimmunityLoss of toleranceAutoantigen targetsLupus erythematosusAutoimmune stateB cellsImmune systemNuclear autoantigensDiseaseErythematosusAutoimmunityAutoantigens
1999
Autoreactive T cells in murine lupus
Craft J, Peng S, Fujii T, Okada M, Fatenejad S. Autoreactive T cells in murine lupus. Immunologic Research 1999, 19: 245-257. PMID: 10493178, DOI: 10.1007/bf02786492.Peer-Reviewed Original ResearchLessons from Knockout and Transgenic Lupus-Prone Mice
Peng S, Craft J. Lessons from Knockout and Transgenic Lupus-Prone Mice. Contemporary Immunology 1999, 152-166. DOI: 10.1007/978-1-59259-703-1_10.Peer-Reviewed Original ResearchLupus-prone miceSystemic lupus erythematosusNZB ×Disease manifestationsStudy of lupusLupus-like symptomsMRL/MpPathogenesis of lupusB cell toleranceLupus erythematosusImmune deficiencyT cellsImmune organsB cellsDisease pathogenesisImmune systemMurine systemMouse strainsMajority of knowledgeFunctional activityMiceGenetic alterationsLupusHuman disease pathogenesisPathogenesis
1998
Perforin protects against autoimmunity in lupus-prone mice.
Peng S, Moslehi J, Robert M, Craft J. Perforin protects against autoimmunity in lupus-prone mice. The Journal Of Immunology 1998, 160: 652-60. PMID: 9551899, DOI: 10.4049/jimmunol.160.2.652.Peer-Reviewed Original ResearchConceptsLupus-prone miceAutoantibody productionImmune complex renal diseaseLupus-prone animalsPerforin-mediated cytotoxicityEnd-organ diseaseComplex renal diseaseAccelerated autoimmunityRenal diseaseLpr miceImmune homeostasisSystemic autoimmunityT cellsImmune systemAbnormal accumulationLpr animalsAutoimmunityFas AgMiceHypergammaglobulinemiaPerforinDiseaseAnimalsSpecific mechanismsRegulatory mechanisms