2013
The nanomaterial-dependent modulation of dendritic cells and its potential influence on therapeutic immunosuppression in lupus
Look M, Saltzman WM, Craft J, Fahmy TM. The nanomaterial-dependent modulation of dendritic cells and its potential influence on therapeutic immunosuppression in lupus. Biomaterials 2013, 35: 1089-1095. PMID: 24183697, PMCID: PMC4164020, DOI: 10.1016/j.biomaterials.2013.10.046.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDendritic CellsDrug CarriersFemaleImmunosuppression TherapyImmunosuppressive AgentsLactic AcidLupus Erythematosus, SystemicMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred NZBMycophenolic AcidNanogelsPermeabilityPolyethylene GlycolsPolyethyleneiminePolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerConceptsDendritic cellsTherapeutic immunosuppressionLupus-prone NZB/W F1 miceNZB/W F1 miceW F1 miceCell immunosuppressionImmunosuppressive therapyInflammatory cytokinesImmune modulatorsF1 miceImmune responseImmunosuppressionVivo efficacySurface markersMycophenolic acidGreater reductionParticulate uptakeAttractive modalityEfficacyCellsNanoparticulate platformSuccessful deliveryImmunosuppressantsLupusCytokinesNanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice
Look M, Stern E, Wang QA, DiPlacido LD, Kashgarian M, Craft J, Fahmy TM. Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice. Journal Of Clinical Investigation 2013, 123: 1741-1749. PMID: 23454752, PMCID: PMC3613921, DOI: 10.1172/jci65907.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusMedian survival timeMycophenolic acidLupus erythematosusImmune cellsLupus-prone NZB/W F1 miceNZB/W F1 miceSimilar therapeutic resultsW F1 miceSevere renal damageCD4 T cellsAntigen-presenting cellsLupus therapyRenal damageIL-12Immunosuppressant mycophenolic acidInflammatory cytokinesProphylactic useTherapeutic resultsF1 miceT cellsSurvival timeGreater dosesErythematosusImmunosuppression
2011
An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells
Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM. An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells. Immunity 2011, 35: 792-805. PMID: 22118527, PMCID: PMC3431922, DOI: 10.1016/j.immuni.2011.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCell DifferentiationGene Expression Regulation, DevelopmentalImmunologic MemoryInterleukin-10InterleukinsMiceMice, KnockoutPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-bcl-6Signal TransductionSTAT3 Transcription FactorSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling ProteinsT-Box Domain ProteinsTranscription FactorsConceptsMemory T cellsT cellsBCL-6Protective memory T cellsCentral memory T cellsSTAT3 pathwayAcute LCMV infectionExpression of EomesLong-term immunityMemory precursor cellsSTAT3-SOCS3 pathwayMemory cell developmentCell developmentT cell developmentMemory CD8IL-21LCMV infectionIL-12Interleukin-10Inflammatory cytokinesFunctional maturationSOCS3 expressionBlimp-1Precursor cellsSTAT3
2009
ICOS Controls Effector Function but Not Trafficking Receptor Expression of Kidney-Infiltrating Effector T Cells in Murine Lupus
Odegard JM, DiPlacido LD, Greenwald L, Kashgarian M, Kono DH, Dong C, Flavell RA, Craft J. ICOS Controls Effector Function but Not Trafficking Receptor Expression of Kidney-Infiltrating Effector T Cells in Murine Lupus. The Journal Of Immunology 2009, 182: 4076-4084. PMID: 19299705, PMCID: PMC2746004, DOI: 10.4049/jimmunol.0800758.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Differentiation, T-LymphocyteAutoantibodiesAutoantigensB-LymphocytesCD4-Positive T-LymphocytesChemokine CXCL9Chemotaxis, LeukocyteCytokinesDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFlow CytometryFluorescent Antibody TechniqueInducible T-Cell Co-Stimulator ProteinKidneyLupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred MRL lprMice, TransgenicP-SelectinReceptors, CCR5Receptors, CXCR3ConceptsCD4 T cellsT cellsPerivascular infiltratesP-selectin ligandsMurine lupusReceptor expressionEffector functionsAutoreactive CD4 T cellsKidney-infiltrating T cellsEffector CD4 T cellsChemokine protein levelsEffector cell numbersIgG autoantibody productionExpression of CXCR3Effector T cellsSystemic lupus erythematosusImmune complex glomerulonephritisCellular inflammatory responseAutoantibody depositionComplex glomerulonephritisLupus erythematosusAutoantibody productionInflammatory chemokinesInflammatory cytokinesLigands CXCL9